MutS complex

GO:1990710 · Other · Multiprotein complex · Proposed

A homodimeric mismatch repair complex involved in binding to and correcting insertion/deletion mutations. [GO:1990710]

Synonyms: MutS mismatch repair complex

Components

Component	Type	Part of / acts on	Grounding	Genes	Stoichiometry	Essential	Role
MutS subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	mutS	2 copies per homodimeric MutS complex	UNKNOWN	MutS-family mismatch-recognition subunit that forms the homodimeric bacterial MutS complex. `GO:1990710` GO:1990710 defines the MutS complex as a homodimeric mismatch repair complex. `DOI:10.1038/35037509` Obmolova et al. 2000 reported MutS crystal structures, including a MutS-substrate DNA complex.

NCBITaxon:562 Escherichia coli — COMMON: Escherichia coli has a MutS mismatch-repair complex used as a bacterial example by GO:1990710. [PMID:21666597]

NCBITaxon:562 Escherichia coli — Bacterial MutS reference system for atomic-force microscopy of MutS oligomers initiating DNA mismatch repair. [DOI:10.1038/emboj.2011.180]

mismatch repair GO:0006298 — The MutS complex binds mismatched DNA and supports DNA mismatch repair.
- GO:1990710 GO:1990710 defines the MutS complex as a mismatch repair complex involved in binding and correcting insertion/deletion mutations.
- GO:0006298 GO:0006298 is the Gene Ontology biological-process term for mismatch repair.

A MutS homodimer forms a mismatch-repair complex that binds mismatched DNA and supports mismatch repair.

Subject	Predicate	Object	Evidence
MutS subunit	contributes to	MutS complex	`GO:1990710` GO:1990710 defines MutS as a homodimeric mismatch repair complex. `DOI:10.1038/35037509` Obmolova et al. 2000 reported MutS crystal structures.
MutS complex	binds	mismatched DNA	`GO:1990710` GO:1990710 defines the MutS complex as involved in binding mismatches. `DOI:10.1038/35037523` Lamers et al. 2000 reported the crystal structure of MutS binding to a G-T mismatch.
MutS complex	supports	mismatch repair	`GO:1990710` GO:1990710 defines MutS as a mismatch repair complex. `GO:0006298` GO:0006298 is the biological-process term for mismatch repair.

CURATION_TODO (OPEN): Resolve an exact source-neutral family grounding for the MutS constituent of the homodimeric MutS complex. GO:1990710 exactly identifies the homodimeric MutS complex, but exact InterPro, Pfam, NCBIfam or UniProtKB family boundaries for the bacterial MutS subunit class need narrower follow-up curation.

GO:1990710 Gene Ontology cellular-component term for the MutS complex.
GO:0032991 Gene Ontology cellular-component parent term for protein-containing complexes.
GO:0006298 Gene Ontology biological-process term for mismatch repair.
PMID:21666597 PubMed identifier for Jiang and Marszalek 2011, the EMBO Journal paper cited by the GO:1990710 definition.
DOI:10.1038/emboj.2011.180 DOI for Jiang and Marszalek 2011, verified through PubMed and PMC.
PMID:11048710 PubMed identifier for Obmolova et al. 2000, the Nature paper on MutS and MutS-substrate-DNA crystal structures.
DOI:10.1038/35037509 DOI for Obmolova et al. 2000, verified through PubMed.
PMID:11048711 PubMed identifier for Lamers et al. 2000, the Nature paper on MutS bound to a G-T mismatch.
DOI:10.1038/35037523 DOI for Lamers et al. 2000, verified through PubMed.

2026-09-27T11:19:30Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-09-27T11:20:17Z codex · EXPANDED_RECORD — Added GO MutS synonymy, protein-containing-complex parentage, a reviewed-label-only MutS constituent row, E. coli scope, mismatch-repair function evidence, GO/PubMed/DOI evidence, a nonmechanistic function graph, and a MutS subunit-grounding TODO.