Noc4p-Nop14p complex

GO:0030692 · Other · Multiprotein complex · Proposed

A heterodimer associated with precursors of the eukaryotic small ribosomal subunit, including the 90S preribosome; involved in small subunit biogenesis. [GO:0030692]

Part of: 90S preribosome (GO:0030686); preribosome, small subunit precursor (GO:0030688)

UniProt location names: UniProt Consortium, CC BY 4.0. Reference label and route sources.

Components

Component	Type	Part of / acts on	Grounding	Genes	Stoichiometry	Essential	Role
Noc4 Noc-complex subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	NOC4	one copy per heterodimer	UNKNOWN	Protein constituent that forms the budding-yeast Noc4p-Nop14p heterodimer associated with small-subunit preribosomal precursors. `GO:0030692` GO:0030692 identifies Noc4p in the Noc4p-Nop14p heterodimer associated with 90S and small-subunit preribosomes. `DOI:10.1074/jbc.M208898200` Milkereit et al. 2003 reported that Noc4p and Nop14p form a Noc complex with a specific role in nucleolar 40S subunit formation.
Nop14 Noc-complex subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	NOP14	one copy per heterodimer	UNKNOWN	Nucleolar protein constituent that forms the budding-yeast Noc4p-Nop14p heterodimer. `GO:0030692` GO:0030692 defines the Noc4p-Nop14p complex as a heterodimer associated with small-subunit preribosomal precursors. `DOI:10.1074/jbc.M208898200` Milkereit et al. 2003 described Nop14p as the partner of Noc4p in a Noc complex involved in 40S subunit formation.

Taxonomic distribution

NCBITaxon:4932 Saccharomyces cerevisiae — COMMON: Budding yeast is the organism in which Noc4p-Nop14p was described as a heterodimeric Noc complex involved in 40S subunit biogenesis. [DOI:10.1074/jbc.M208898200]

Canonical examples

NCBITaxon:4932 Saccharomyces cerevisiae — Milkereit et al. 2003 reported budding-yeast Noc4p/Nop14p as a Noc complex with a specific role in nucleolar 40S subunit formation and nuclear export. [DOI:10.1074/jbc.M208898200]

Functions

ribosomal small subunit biogenesis GO:0042274 — The Noc4p-Nop14p complex is associated with 90S and small-subunit preribosomal precursors and supports maturation of the eukaryotic small ribosomal subunit lineage.
- GO:0030692 GO:0030692 defines the Noc4p-Nop14p complex as involved in small subunit biogenesis.
- GO:0042274 GO:0042274 is the Gene Ontology biological-process term for ribosomal small subunit biogenesis.
- DOI:10.1074/jbc.M208898200 Milkereit et al. 2003 connected the Noc4p/Nop14p complex to nucleolar 40S subunit formation and subsequent export.

Mechanism graphs

Noc4p-Nop14p supports small-subunit biogenesis (FUNCTION)

In Saccharomyces cerevisiae, Noc4p and Nop14p form a heterodimeric Noc complex associated with precursors of the eukaryotic small ribosomal subunit, including the 90S preribosome.

Subject	Predicate	Object	Evidence
Noc4 Noc-complex subunit	contributes to	Noc4p-Nop14p complex	`DOI:10.1074/jbc.M208898200` Milkereit et al. 2003 identified Noc4p as a constituent of the Noc4p/Nop14p Noc complex.
Nop14 Noc-complex subunit	contributes to	Noc4p-Nop14p complex	`DOI:10.1074/jbc.M208898200` Milkereit et al. 2003 identified Nop14p as a constituent of the Noc4p/Nop14p Noc complex.
Noc4p-Nop14p complex	associates with	90S preribosome	`GO:0030692` GO:0030692 defines the Noc4p-Nop14p complex as associated with small-subunit precursors that include the 90S preribosome.
Noc4p-Nop14p complex	associates with	preribosome, small subunit precursor	`GO:0030692` GO:0030692 carries a part_of relationship to GO:0030688, the small-subunit preribosome precursor.
Noc4p-Nop14p complex	participates in	ribosomal small subunit biogenesis	`GO:0030692` GO:0030692 defines this complex as involved in small subunit biogenesis. `GO:0042274` GO:0042274 is the process term for ribosomal small subunit biogenesis. `DOI:10.1074/jbc.M208898200` Milkereit et al. 2003 reported a specific role for Noc4p and Nop14p in nucleolar 40S subunit formation and export.

Discussions

CURATION_TODO (OPEN): Resolve exact source-neutral family groundings for the Noc4 and Nop14 constituents of the Noc4p-Nop14p complex. GO:0030692 uses Saccharomyces gene-product names while noting that analogous complexes in other eukaryotes can use the term. Exact cross-eukaryotic InterPro, Pfam, NCBIfam or UniProt family boundaries for Noc4 and Nop14 need narrower follow-up curation before these component labels can be grounded.

Evidence

GO:0030692 Gene Ontology cellular-component term for the Noc4p-Nop14p complex.
GO:0030689 Gene Ontology cellular-component parent term for Noc complexes.
GO:0030686 Gene Ontology cellular-component term for the 90S preribosome.
GO:0030688 Gene Ontology cellular-component term for the small-subunit preribosome precursor.
GO:0042274 Gene Ontology biological-process term for ribosomal small subunit biogenesis.
PMID:12446671 PubMed identifier for Milkereit et al. 2003, the Journal of Biological Chemistry paper cited by the GO Noc4p-Nop14p term.
DOI:10.1074/jbc.M208898200 DOI for Milkereit et al. 2003, 'A Noc complex specifically involved in the formation and nuclear export of ribosomal 40 S subunits', verified through NCBI E-utilities.

Curation history

2026-09-25T21:09:23Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-09-25T21:10:34Z codex · EXPANDED_RECORD — Added Noc-complex parentage, 90S and small-subunit preribosome parthood, Noc4 and Nop14 constituent rows, budding-yeast scope, a small-subunit biogenesis function, GO/PubMed/DOI evidence, a nonmechanistic Noc4p-Nop14p graph, and a subunit-grounding TODO.

Source: data/structures/other/noc4p_nop14p_complex.yaml