NuA3a histone acetyltransferase complex

GO:1990467 · Other · Multiprotein complex · Proposed

A NuA3 complex that catalyzes the acetylation of Histone H3. In S. cerevisiae, this complex consists of Eaf6p, Nto1p, Sas3p, Taf14p, Yng1p and associates with H3K4me3 using Yng1p. [GO:1990467]

UniProt location names: UniProt Consortium, CC BY 4.0. Reference label and route sources.

Components

Component	Type	Part of / acts on	Grounding	Genes	Essential	Role
Eaf6 NuA3a subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	EAF6	UNKNOWN	Protein constituent shared by the budding-yeast NuA3a and NuA3b complexes. `GO:1990467` GO:1990467 defines the budding-yeast NuA3a complex as containing Eaf6p. `DOI:10.1074/mcp.M114.038224` Gilbert et al. 2014 classified NuA3a as the Eaf6p/Nto1p/Sas3p/Taf14p/Yng1p form of NuA3.
Nto1 NuA3a subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	NTO1	UNKNOWN	Protein constituent shared by the budding-yeast NuA3a and NuA3b complexes. `GO:1990467` GO:1990467 defines the budding-yeast NuA3a complex as containing Nto1p. `DOI:10.1074/mcp.M114.038224` Gilbert et al. 2014 classified NuA3a as the Eaf6p/Nto1p/Sas3p/Taf14p/Yng1p form of NuA3.
Sas3 NuA3a catalytic subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	SAS3	UNKNOWN	Catalytic MYST-family histone acetyltransferase constituent shared by the budding-yeast NuA3a and NuA3b complexes. `GO:1990467` GO:1990467 defines the budding-yeast NuA3a complex as containing Sas3p. `DOI:10.1074/mcp.M114.038224` Gilbert et al. 2014 classified NuA3a as the Eaf6p/Nto1p/Sas3p/Taf14p/Yng1p form of NuA3.
Taf14 NuA3a subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	TAF14	UNKNOWN	YEATS-domain constituent shared by the budding-yeast NuA3a and NuA3b complexes. `GO:1990467` GO:1990467 defines the budding-yeast NuA3a complex as containing Taf14p. `DOI:10.1074/mcp.M114.038224` Gilbert et al. 2014 classified NuA3a as the Eaf6p/Nto1p/Sas3p/Taf14p/Yng1p form of NuA3.
Yng1 NuA3a reader subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	YNG1	UNKNOWN	NuA3a-specific PHD-finger reader constituent that links the budding-yeast NuA3a complex to H3K4me3. `GO:1990467` GO:1990467 defines the budding-yeast NuA3a complex as containing Yng1p. `DOI:10.1074/mcp.M114.038224` Gilbert et al. 2014 classified NuA3a as the Eaf6p/Nto1p/Sas3p/Taf14p/Yng1p form of NuA3.

Taxonomic distribution

NCBITaxon:4932 Saccharomyces cerevisiae — COMMON: Budding yeast is the organism in which GO:1990467 defines the NuA3a complex as containing Eaf6p, Nto1p, Sas3p, Taf14p and Yng1p. [GO:1990467]

Canonical examples

NCBITaxon:4932 Saccharomyces cerevisiae — Gilbert et al. 2014 separated budding-yeast NuA3 into the Yng1p-containing NuA3a complex and the Pdp3p-containing NuA3b complex. [DOI:10.1074/mcp.M114.038224]

Functions

histone acetyltransferase activity GO:0004402 — The NuA3a complex catalyzes histone H3 acetylation through its Sas3 catalytic subunit and associates with H3K4me3 using Yng1p.
- GO:1990467 GO:1990467 defines NuA3a as a NuA3 complex that catalyzes histone H3 acetylation.
- GO:0004402 GO:0004402 is the Gene Ontology molecular-function term for histone acetyltransferase activity.
- DOI:10.1074/mcp.M114.038224 Gilbert et al. 2014 distinguished Yng1p-associated NuA3a from Pdp3p-associated NuA3b.

Mechanism graphs

NuA3a carries yeast histone acetyltransferase activity (FUNCTION)

In Saccharomyces cerevisiae, Eaf6p, Nto1p, Sas3p, Taf14p and Yng1p form the NuA3a histone acetyltransferase complex.

Subject	Predicate	Object	Evidence
Eaf6 NuA3a subunit	contributes to	NuA3a histone acetyltransferase complex	`GO:1990467` GO:1990467 defines Eaf6p as a NuA3a constituent. `DOI:10.1074/mcp.M114.038224` Gilbert et al. 2014 classified NuA3a by affinity purification and mass spectrometry.
Nto1 NuA3a subunit	contributes to	NuA3a histone acetyltransferase complex	`GO:1990467` GO:1990467 defines Nto1p as a NuA3a constituent. `DOI:10.1074/mcp.M114.038224` Gilbert et al. 2014 classified NuA3a by affinity purification and mass spectrometry.
Sas3 NuA3a catalytic subunit	contributes to	NuA3a histone acetyltransferase complex	`GO:1990467` GO:1990467 defines Sas3p as a NuA3a constituent. `DOI:10.1074/mcp.M114.038224` Gilbert et al. 2014 classified NuA3a by affinity purification and mass spectrometry.
Taf14 NuA3a subunit	contributes to	NuA3a histone acetyltransferase complex	`GO:1990467` GO:1990467 defines Taf14p as a NuA3a constituent. `DOI:10.1074/mcp.M114.038224` Gilbert et al. 2014 classified NuA3a by affinity purification and mass spectrometry.
Yng1 NuA3a reader subunit	contributes to	NuA3a histone acetyltransferase complex	`GO:1990467` GO:1990467 defines Yng1p as a NuA3a constituent. `DOI:10.1074/mcp.M114.038224` Gilbert et al. 2014 classified NuA3a by affinity purification and mass spectrometry.
NuA3a histone acetyltransferase complex	supports	histone acetyltransferase activity	`GO:1990467` GO:1990467 defines NuA3a as a NuA3 histone H3 acetyltransferase complex. `GO:0004402` GO:0004402 is the molecular-function term for histone acetyltransferase activity. `DOI:10.1074/mcp.M114.038224` Gilbert et al. 2014 classified Yng1p-associated NuA3a as a NuA3 form containing the Sas3 histone acetyltransferase subunit.

Discussions

CURATION_TODO (OPEN): Resolve exact source-neutral family groundings for the NuA3a constituents. GO:1990467 defines five budding-yeast proteins as NuA3a constituents. Exact source-neutral InterPro, Pfam, NCBIfam or UniProt family boundaries for these NuA3a subunit classes need narrower curation before these component labels can be grounded.

Evidence

GO:1990467 Gene Ontology cellular-component term for the NuA3a histone acetyltransferase complex.
GO:0033100 Gene Ontology cellular-component parent term for NuA3 histone acetyltransferase complexes.
GO:0004402 Gene Ontology molecular-function term for histone acetyltransferase activity.
PMID:25104842 PubMed identifier for Gilbert et al. 2014, the budding-yeast NuA3a/NuA3b split-complex paper cited by GO:1990467.
DOI:10.1074/mcp.M114.038224 DOI for Gilbert et al. 2014, 'A PWWP domain-containing protein targets the NuA3 acetyltransferase complex via histone H3 lysine 36 trimethylation to coordinate transcriptional elongation at coding regions', verified through NCBI E-utilities.

Curation history

2026-09-27T04:58:14Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-09-27T04:58:58Z codex · EXPANDED_RECORD — Added NuA3 parentage, five budding-yeast NuA3a constituent rows, budding-yeast scope, histone acetyltransferase activity, GO/PubMed/DOI evidence, a nonmechanistic function graph, and a NuA3a subunit-grounding TODO.

Source: data/structures/other/nua3a_histone_acetyltransferase_complex.yaml