nuclear pore cytoplasmic filaments

GO:0044614 · Other · Multiprotein complex · Proposed

Filamentous extensions on the cytoplasmic face of the eukaryotic nuclear pore complex. [GO:0044614]

Synonyms: cytoplasmic fibers of the NPC

Part of: nuclear pore (GO:0005643)

Components

Component	Type	Part of / acts on	Grounding	Genes	Stoichiometry	Essential	Role
Nup82-family cytoplasmic-filament nucleoporin	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	NUP82		UNKNOWN	Cytoplasmic-face nucleoporin family represented in the Saccharomyces cerevisiae Nup82/Nup159 cytoplasmic filament nucleoporin complex. `DOI:10.1073/pnas.1112846108` Yoshida et al. 2011 structurally analyzed yeast Nup82 in a Nup82/Nup159/Nsp1 nucleoporin heterotrimer on the cytoplasmic face of the NPC. `DOI:10.1038/s41467-017-01160-9` Teimer et al. 2017 characterized a thermophilic-fungus Nup82 cytoplasmic-face complex and its connection to the Y-complex.
Nup159-family cytoplasmic-filament nucleoporin	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	NUP159		UNKNOWN	Cytoplasmic-face nucleoporin family represented in the Saccharomyces cerevisiae Nup82/Nup159 cytoplasmic filament nucleoporin complex. `DOI:10.1073/pnas.1112846108` Yoshida et al. 2011 structurally analyzed yeast Nup159 in a Nup82/Nup159/Nsp1 nucleoporin heterotrimer on the cytoplasmic face of the NPC. `DOI:10.1038/s41467-017-01160-9` Teimer et al. 2017 characterized a thermophilic-fungus Nup82 cytoplasmic-face complex, including its Nup159 subunit.

NCBITaxon:4932 Saccharomyces cerevisiae — COMMON: Nup82, Nup159, and Nsp1 form a cytoplasmic-face nucleoporin heterotrimer in budding yeast; no broader fungal distribution is asserted in this first cytoplasmic-filaments record. [DOI:10.1073/pnas.1112846108]

NCBITaxon:4932 Saccharomyces cerevisiae — Budding-yeast model in which the Nup82/Nup159/Nsp1 heterotrimer was structurally analyzed on the cytoplasmic face of the nuclear pore. [DOI:10.1073/pnas.1112846108]

cytoplasmic mRNA export platform — The cytoplasmic-filament Nup82/Nup159 platform helps position mRNA-export machinery on the cytoplasmic face of the nuclear pore.
- DOI:10.1534/genetics.111.127803 Aitchison and Rout 2012 review the yeast Nup82 complex in mRNA export at the cytoplasmic side of the NPC.

Saccharomyces Nup82 and Nup159 contribute to a cytoplasmic filament nucleoporin module on the cytoplasmic face of the nuclear pore.

Subject	Predicate	Object	Evidence
Nup82-family cytoplasmic-filament nucleoporin	contributes to	nuclear pore cytoplasmic filaments	`DOI:10.1073/pnas.1112846108` Yoshida et al. 2011 structurally analyzed the yeast Nup82/Nup159/Nsp1 heterotrimer on the cytoplasmic face of the NPC.
Nup159-family cytoplasmic-filament nucleoporin	contributes to	nuclear pore cytoplasmic filaments	`DOI:10.1073/pnas.1112846108` Yoshida et al. 2011 structurally analyzed the yeast Nup82/Nup159/Nsp1 heterotrimer on the cytoplasmic face of the NPC.

CURATION_TODO (OPEN): Resolve whether Nsp1, Nup116-family linker Nups, Gle2, Nup42, Gle1, Dbp5, Dyn2, and related cytoplasmic mRNA-export factors should be curated as cytoplasmic-filament constituents or associated machinery. Yoshida et al. 2011 structurally analyze the Nup82/Nup159/Nsp1 heterotrimer, but this first record models only Nup82 and Nup159 until central-channel, linker-Nup, and mRNA-export accessory boundaries are reviewed explicitly.

GO:0044614 Gene Ontology cellular-component term for nuclear pore cytoplasmic filaments.
GO:0005643 Gene Ontology cellular-component term for the nuclear pore.
DOI:10.1073/pnas.1112846108 Yoshida et al. 2011, 'Structural and functional analysis of an essential nucleoporin heterotrimer on the cytoplasmic face of the nuclear pore complex', Proceedings of the National Academy of Sciences.
DOI:10.1038/s41467-017-01160-9 Teimer et al. 2017, 'A short linear motif in scaffold Nup145C connects Y-complex with pre-assembled outer ring Nup82 complex', Nature Communications.
DOI:10.1534/genetics.111.127803 Aitchison and Rout 2012, 'The Yeast Nuclear Pore Complex and Transport Through It', Genetics.

2026-09-11T08:35:31Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-09-11T08:36:31Z codex · EXPANDED_RECORD — Added cytoplasmic-fiber synonymy, nuclear-pore parthood, Nup82 and Nup159 cytoplasmic-filament component classes, Ascomycota taxonomic scope, a Saccharomyces cerevisiae example, mRNA-export-platform function, DOI/GO evidence, a conservative Nup82/Nup159 assembly graph, and a CFNC component-boundary TODO.
2026-09-11T08:44:11Z codex · ADDRESSED_REVIEW — Resolved #444 and #445 by replacing human Bley 2022 citations on yeast Nup82/Nup159 claims with fungal Yoshida/Teimer/Aitchison support, narrowing the distribution row to Saccharomyces cerevisiae, and revising the CFNC boundary TODO.