nuclear pore nuclear basket

GO:0044615 · Other · Multiprotein complex · Proposed

A filamentous, cage-like assembly on the nuclear face of the nuclear pore complex. [GO:0044615]

Synonyms: nuclear basket

Part of: nuclear pore (GO:0005643)

Components

Component	Type	Part of / acts on	Grounding	Genes	Stoichiometry	Essential	Role
Mlp1-family nuclear-basket coiled-coil nucleoporin	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	MLP1		UNKNOWN	Large coiled-coil basket-filament family represented in the Saccharomyces cerevisiae nuclear pore basket. `DOI:10.1091/mbc.E13-07-0412` Niepel et al. 2013 identified Mlp1p as a necessary yeast nuclear-basket component. `DOI:10.1242/jcs.264865` Schmidt et al. 2026 refined a budding-yeast nuclear pore basket model containing Mlp1 and Mlp2.
Mlp2-family nuclear-basket coiled-coil nucleoporin	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	MLP2		UNKNOWN	Large coiled-coil basket-filament family represented in the Saccharomyces cerevisiae nuclear pore basket. `DOI:10.1091/mbc.E13-07-0412` Niepel et al. 2013 identified Mlp2p as a necessary yeast nuclear-basket component. `DOI:10.1242/jcs.264865` Schmidt et al. 2026 found that Mlp2 cooperates with Mlp1 to stabilize budding-yeast basket architecture.

NCBITaxon:4932 Saccharomyces cerevisiae — COMMON: Mlp1 and Mlp2 basket filaments are directly characterized in budding yeast; no broader fungal distribution is asserted in this first nuclear-basket record. [DOI:10.1091/mbc.E13-07-0412]

NCBITaxon:4932 Saccharomyces cerevisiae — Budding-yeast model in which Mlp1 and Mlp2 were mapped as core nuclear-basket filament proteins. [DOI:10.1242/jcs.264865]

nucleoplasmic NPC organization platform — Mlp1/Mlp2 nuclear-basket filaments organize a nucleoplasmic NPC platform coupled to mRNA export, NPC positioning, chromatin organization, and nuclear-envelope morphology.
- DOI:10.1091/mbc.E13-07-0412 Niepel et al. 2013 connected Mlp1/Mlp2 basket filaments to mRNP docking, NPC positioning, nuclear stability, and nuclear-envelope morphology.

Saccharomyces Mlp1 and Mlp2 contribute the large coiled-coil filaments of the nuclear pore basket.

Subject	Predicate	Object	Evidence
Mlp1-family nuclear-basket coiled-coil nucleoporin	contributes to	nuclear pore nuclear basket	`DOI:10.1091/mbc.E13-07-0412` Niepel et al. 2013 identified yeast Mlp1p as a nuclear-basket component.
Mlp2-family nuclear-basket coiled-coil nucleoporin	contributes to	nuclear pore nuclear basket	`DOI:10.1091/mbc.E13-07-0412` Niepel et al. 2013 identified yeast Mlp2p as a nuclear-basket component.

CURATION_TODO (OPEN): Resolve which Nup60, Nup1, Nup2, and Pml39 basket Nups should be curated as nuclear-basket constituents, and which TREX-2, Ulp1, mRNA-export, SUMO-regulation, or chromatin factors should remain associated machinery. Recent yeast work places Nup60 and Pml39 in basket anchoring and stoichiometry, and additional export or chromatin regulators can be recruited to the basket. This first record models only the unambiguous coiled-coil Mlp1/Mlp2 basket filaments until basket-Nup and recruited-factor boundaries are reviewed explicitly.

GO:0044615 Gene Ontology cellular-component term for the nuclear pore nuclear basket.
GO:0005643 Gene Ontology cellular-component term for the nuclear pore.
DOI:10.1242/jcs.264865 Schmidt et al. 2026, 'Mlp1 and Mlp2 cooperate to build a stoichiometric nuclear pore basket in budding yeast', Journal of Cell Science.
DOI:10.1091/mbc.E13-07-0412 Niepel et al. 2013, 'The nuclear basket proteins Mlp1p and Mlp2p are part of a dynamic interactome including Esc1p and the proteasome', Molecular Biology of the Cell.
DOI:10.1038/s41556-024-01484-x Stankunas and Kohler 2024, 'Docking a flexible basket onto the core of the nuclear pore complex', Nature Cell Biology.
DOI:10.1016/j.devcel.2015.02.017 Meszaros et al. 2015, 'Nuclear pore basket proteins are tethered to the nuclear envelope and can regulate membrane curvature', Developmental Cell.

2026-09-11T08:54:16Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-09-11T08:54:53Z codex · EXPANDED_RECORD — Added nuclear-basket synonymy, nuclear-pore parthood, Mlp1 and Mlp2 yeast basket-filament component classes, a Saccharomyces cerevisiae distribution row and example, DOI/GO evidence, a conservative Mlp1/Mlp2 assembly graph, and a nuclear-basket component-boundary TODO.
2026-09-11T09:02:13Z codex · ADDRESSED_REVIEW — Resolved #447 and #448 by broadening the basket function label to nucleoplasmic NPC organization and splitting the boundary TODO into structural basket-Nup and recruited-factor candidates.