nuclear pore outer ring

GO:0031080 · Other · Multiprotein complex · Proposed

A ring-shaped eukaryotic nuclear pore subcomplex built from outer-ring coat nucleoporins on the cytoplasmic and nucleoplasmic faces of the nuclear pore scaffold. [GO:0031080]

Synonyms: Nup84 complex; Nup107-160 complex; Y complex

Part of: nuclear pore (GO:0005643)

UniProt location names: UniProt Consortium, CC BY 4.0. Reference label and route sources.

Components

Component	Type	Part of / acts on	Grounding	Genes	Essential	Role
Nup84/Nup107-family nucleoporin	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	NUP84	UNKNOWN	Coat nucleoporin family represented in the Saccharomyces cerevisiae Nup84/Y-complex outer-ring subcomplex. `DOI:10.1093/emboj/21.3.387` Lutzmann et al. 2002 reconstituted the Saccharomyces Nup84 complex from Nup84, Nup85, Nup120, Nup133, Nup145C, Sec13, and Seh1. `DOI:10.1083/jcb.201109008` Fernandez-Martinez et al. 2012 mapped the heptameric Saccharomyces Nup84 module in the nuclear pore complex.
Nup85-family nucleoporin	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	NUP85	UNKNOWN	Coat nucleoporin family represented in the Saccharomyces cerevisiae Nup84/Y-complex outer-ring subcomplex. `DOI:10.1093/emboj/21.3.387` Lutzmann et al. 2002 reconstituted the Saccharomyces Nup84 complex from Nup84, Nup85, Nup120, Nup133, Nup145C, Sec13, and Seh1. `DOI:10.1083/jcb.201109008` Fernandez-Martinez et al. 2012 mapped the heptameric Saccharomyces Nup84 module in the nuclear pore complex.
Nup120/Nup160-family nucleoporin	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	NUP120	UNKNOWN	Coat nucleoporin family represented in the Saccharomyces cerevisiae Nup84/Y-complex outer-ring subcomplex. `DOI:10.1093/emboj/21.3.387` Lutzmann et al. 2002 reconstituted the Saccharomyces Nup84 complex from Nup84, Nup85, Nup120, Nup133, Nup145C, Sec13, and Seh1. `DOI:10.1083/jcb.201109008` Fernandez-Martinez et al. 2012 mapped the heptameric Saccharomyces Nup84 module in the nuclear pore complex.
Nup133-family nucleoporin	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	NUP133	UNKNOWN	Coat nucleoporin family represented in the Saccharomyces cerevisiae Nup84/Y-complex outer-ring subcomplex. `DOI:10.1093/emboj/21.3.387` Lutzmann et al. 2002 reconstituted the Saccharomyces Nup84 complex from Nup84, Nup85, Nup120, Nup133, Nup145C, Sec13, and Seh1. `DOI:10.1083/jcb.201109008` Fernandez-Martinez et al. 2012 mapped the heptameric Saccharomyces Nup84 module in the nuclear pore complex.
Nup145C/Nup96-family nucleoporin	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	NUP145	UNKNOWN	Coat nucleoporin family represented in the Saccharomyces cerevisiae Nup84/Y-complex outer-ring subcomplex. `DOI:10.1093/emboj/21.3.387` Lutzmann et al. 2002 reconstituted the Saccharomyces Nup84 complex from Nup84, Nup85, Nup120, Nup133, Nup145C, Sec13, and Seh1. `DOI:10.1083/jcb.201109008` Fernandez-Martinez et al. 2012 mapped the heptameric Saccharomyces Nup84 module in the nuclear pore complex.
Sec13-family nucleoporin	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	SEC13	UNKNOWN	Coat nucleoporin family represented in the Saccharomyces cerevisiae Nup84/Y-complex outer-ring subcomplex. `DOI:10.1093/emboj/21.3.387` Lutzmann et al. 2002 reconstituted the Saccharomyces Nup84 complex from Nup84, Nup85, Nup120, Nup133, Nup145C, Sec13, and Seh1. `DOI:10.1083/jcb.201109008` Fernandez-Martinez et al. 2012 mapped the heptameric Saccharomyces Nup84 module in the nuclear pore complex.
Seh1-family nucleoporin	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	SEH1	UNKNOWN	Coat nucleoporin family represented in the Saccharomyces cerevisiae Nup84/Y-complex outer-ring subcomplex. `DOI:10.1093/emboj/21.3.387` Lutzmann et al. 2002 reconstituted the Saccharomyces Nup84 complex from Nup84, Nup85, Nup120, Nup133, Nup145C, Sec13, and Seh1. `DOI:10.1083/jcb.201109008` Fernandez-Martinez et al. 2012 mapped the heptameric Saccharomyces Nup84 module in the nuclear pore complex.

Taxonomic distribution

NCBITaxon:2759 Eukaryota — COMMON: Outer-ring Nup84/Nup107-160/Y-complex coat nucleoporins are broadly conserved in eukaryotic nuclear pores, with lineage-specific differences in stoichiometry and accessory nucleoporins. [DOI:10.1146/annurev-biophys-052118-115308]

Canonical examples

NCBITaxon:4932 Saccharomyces cerevisiae — Budding-yeast model in which the heptameric Nup84 outer-ring subcomplex was reconstituted from seven nucleoporins. [DOI:10.1093/emboj/21.3.387]

Functions

nuclear-pore scaffold assembly — The nuclear pore outer ring contributes a coat-nucleoporin scaffold to the assembled NPC.
- DOI:10.1073/pnas.0907453106 Seo et al. 2009 studied Nup120 structure and proposed how the Nup84 complex forms rings.
- DOI:10.1016/j.cell.2021.12.015 Akey et al. 2022 resolved the yeast nuclear pore outer-ring architecture.

Mechanism graphs

Nup84/Y-complex spokes build the outer ring (ASSEMBLY)

Seven Saccharomyces coat-nucleoporin families assemble into a Nup84/Y-complex spoke, and spoke-like modules contribute to the nuclear pore outer-ring scaffold.

Subject	Predicate	Object	Evidence
Nup84/Nup107-family nucleoporin	assembles into	Nup84/Y-complex spoke	`DOI:10.1093/emboj/21.3.387` Lutzmann et al. 2002 reconstituted a Y-shaped Saccharomyces Nup84 complex from seven nucleoporins.
Nup85-family nucleoporin	assembles into	Nup84/Y-complex spoke	`DOI:10.1093/emboj/21.3.387` Lutzmann et al. 2002 reconstituted a Y-shaped Saccharomyces Nup84 complex from seven nucleoporins.
Nup120/Nup160-family nucleoporin	assembles into	Nup84/Y-complex spoke	`DOI:10.1093/emboj/21.3.387` Lutzmann et al. 2002 reconstituted a Y-shaped Saccharomyces Nup84 complex from seven nucleoporins.
Nup133-family nucleoporin	assembles into	Nup84/Y-complex spoke	`DOI:10.1093/emboj/21.3.387` Lutzmann et al. 2002 reconstituted a Y-shaped Saccharomyces Nup84 complex from seven nucleoporins.
Nup145C/Nup96-family nucleoporin	assembles into	Nup84/Y-complex spoke	`DOI:10.1093/emboj/21.3.387` Lutzmann et al. 2002 reconstituted a Y-shaped Saccharomyces Nup84 complex from seven nucleoporins.
Sec13-family nucleoporin	assembles into	Nup84/Y-complex spoke	`DOI:10.1093/emboj/21.3.387` Lutzmann et al. 2002 reconstituted a Y-shaped Saccharomyces Nup84 complex from seven nucleoporins.
Seh1-family nucleoporin	assembles into	Nup84/Y-complex spoke	`DOI:10.1093/emboj/21.3.387` Lutzmann et al. 2002 reconstituted a Y-shaped Saccharomyces Nup84 complex from seven nucleoporins.
Nup84/Y-complex spoke	forms spoke of	nuclear pore outer ring	`GO:0031080` GO:0031080 treats isolated Nup84 complexes as spokes of the nuclear pore outer ring. `DOI:10.1073/pnas.0907453106` Seo et al. 2009 used Nup120 structure to propose ring formation by the Nup84 complex.

Discussions

CURATION_TODO (OPEN): Resolve exact source-neutral protein-family groundings for Nup84/Y-complex outer-ring nucleoporin classes. Nup84/Y-complex members have several paralog and ortholog names across fungi and vertebrates; this first record avoids guessing one exact InterPro, Pfam, NCBIfam, or UniProtKB accession for each source-neutral component class.

Evidence

GO:0031080 Gene Ontology cellular-component term for the nuclear pore outer ring.
GO:0005643 Gene Ontology cellular-component term for the nuclear pore.
DOI:10.1093/emboj/21.3.387 Lutzmann et al. 2002, 'Modular self-assembly of a Y-shaped multiprotein complex from seven nucleoporins', EMBO Journal.
DOI:10.1073/pnas.0907453106 Seo et al. 2009, 'Structural and functional analysis of Nup120 suggests ring formation of the Nup84 complex', Proceedings of the National Academy of Sciences.
DOI:10.1083/jcb.201109008 Fernandez-Martinez et al. 2012, 'Structure-function mapping of a heptameric module in the nuclear pore complex', Journal of Cell Biology.
DOI:10.1016/j.cell.2021.12.015 Akey et al. 2022, 'Comprehensive structure and functional adaptations of the yeast nuclear pore complex', Cell.
DOI:10.1146/annurev-biophys-052118-115308 Hampoelz et al. 2019, 'Structure and Assembly of the Nuclear Pore Complex', Annual Review of Biophysics.

Curation history

2026-09-11T06:40:26Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-09-11T06:42:25Z codex · EXPANDED_RECORD — Added Nup84/Nup107 and Nup107-160 synonymy, nuclear-pore parthood, seven Nup84/Y-complex component classes, Eukaryota distribution, a Saccharomyces cerevisiae example, nuclear-pore scaffold function, DOI/GO evidence, an outer-ring assembly graph, and a Y-complex grounding TODO.
2026-09-11T06:51:25Z codex · ADDRESSED_REVIEW — Resolved #431 and #432 by routing Nup84 component edges through an intermediate Nup84/Y-complex spoke node before the outer ring and narrowing the Saccharomyces cerevisiae example to the Lutzmann-supported reconstitution claim.

Source: data/structures/other/nuclear_pore_outer_ring.yaml