ribonuclease III complex

GO:1903095 · Other · Multiprotein complex · Proposed

A protein complex which is capable of ribonuclease III activity. [GO:1903095]

UniProt location names: UniProt Consortium, CC BY 4.0. Reference label and route sources.

Functions

ribonuclease III activity GO:0004525 — The ribonuclease III complex catalyzes staggered endonucleolytic cleavage of double-stranded RNA.
- GO:0004525 GO:0004525 is the Gene Ontology molecular-function term for ribonuclease III activity.
- GO:1903095 GO:1903095 defines the ribonuclease III complex as a protein complex capable of ribonuclease III activity.

Mechanism graphs

RNase III complex cleaves double-stranded RNA (FUNCTION)

GO defines the ribonuclease III complex as an endoribonuclease complex capable of ribonuclease III activity, the staggered endonucleolytic cleavage of double-stranded RNA.

Subject	Predicate	Object	Evidence
ribonuclease III complex	enables	ribonuclease III activity	`GO:1903095` GO:1903095 defines the complex as capable of ribonuclease III activity. `GO:0004525` GO:0004525 is the molecular-function term for ribonuclease III activity.
double-stranded RNA	is cleaved by	ribonuclease III activity	`GO:0004525` GO:0004525 defines ribonuclease III activity as making two staggered cuts in both strands of dsRNA.

Discussions

CURATION_TODO (OPEN): Resolve exact source-neutral component boundaries for ribonuclease III complexes. The first GO:1903095 record captures the GO-defined RNase III complex identity and RNase III molecular activity. Exact source-neutral RNase III family boundaries and the correct split between generic, bacterial and eukaryotic assemblies should be curated from primary component evidence before assigning constituents.

Evidence

GO:1903095 Gene Ontology cellular-component term for the ribonuclease III complex.
GO:1902555 Gene Ontology cellular-component term for endoribonuclease complexes.
GO:0004525 Gene Ontology molecular-function term for ribonuclease III activity.
PMID:22393237 RNase III complex activity publication cited in the GO:1903095 definition xrefs.

Curation history

2026-09-25T16:04:23Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-09-25T16:05:47Z codex · EXPANDED_RECORD — Added GO endoribonuclease-complex parentage, a GO-backed RNase III function, GO/PubMed evidence, a nonmechanistic dsRNA-cleavage graph and a component-boundary TODO.

Source: data/structures/other/ribonuclease_iii_complex.yaml