RSC-type complex

GO:0016586 · Other · Multiprotein complex · Proposed

A SWI/SNF-type complex that contains a bromodomain containing-protein, such as yeast Rsc1 or Rsc4 or mammalian PB1/BAF180. The RSC complex is generally recruited to RNA polymerase III promoters and is specifically recruited to RNA polymerase II promoters by transcriptional activators and repressors; it is also involved in non-homologous end joining. [GO:0016586]

Synonyms: PBAF complex; Polybromo- and BAF containing complex; SWI/SNF complex B

UniProt location names: UniProt Consortium, CC BY 4.0. Reference label and route sources.

Components

Component	Type	Part of / acts on	Grounding	Genes	Essential	Role
Sth1 RSC ATPase subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	STH1	UNKNOWN	ATPase-containing catalytic constituent of the budding-yeast RSC chromatin remodeler. `DOI:10.7554/eLife.54449` Patel et al. 2019 purified Saccharomyces cerevisiae RSC through tagged Sth1, described RSC as 17 proteins with two Rsc8 copies and either Rsc1 or Rsc2, and used cryo-EM and crosslinking mass spectrometry to assign RSC subunit architecture.
Sfh1 RSC core subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	SFH1	UNKNOWN	Evolutionarily conserved RSC core constituent that contributes to nucleosome engagement. `DOI:10.7554/eLife.54449` Patel et al. 2019 purified Saccharomyces cerevisiae RSC through tagged Sth1, described RSC as 17 proteins with two Rsc8 copies and either Rsc1 or Rsc2, and used cryo-EM and crosslinking mass spectrometry to assign RSC subunit architecture.
Rsc6 RSC core subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	RSC6	UNKNOWN	Evolutionarily conserved core constituent of the body lobe. `DOI:10.7554/eLife.54449` Patel et al. 2019 purified Saccharomyces cerevisiae RSC through tagged Sth1, described RSC as 17 proteins with two Rsc8 copies and either Rsc1 or Rsc2, and used cryo-EM and crosslinking mass spectrometry to assign RSC subunit architecture.
Rsc8 RSC core subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	RSC8	UNKNOWN	Dimeric backbone constituent that scaffolds the RSC head, body and arm lobes. `DOI:10.7554/eLife.54449` Patel et al. 2019 purified Saccharomyces cerevisiae RSC through tagged Sth1, described RSC as 17 proteins with two Rsc8 copies and either Rsc1 or Rsc2, and used cryo-EM and crosslinking mass spectrometry to assign RSC subunit architecture.
Rsc9 RSC core subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	RSC9	UNKNOWN	Core body-lobe constituent of the budding-yeast RSC complex. `DOI:10.7554/eLife.54449` Patel et al. 2019 purified Saccharomyces cerevisiae RSC through tagged Sth1, described RSC as 17 proteins with two Rsc8 copies and either Rsc1 or Rsc2, and used cryo-EM and crosslinking mass spectrometry to assign RSC subunit architecture.
Arp7 RSC Arp module subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	ARP7	UNKNOWN	Actin-related-protein constituent of the RSC Arp module. `DOI:10.7554/eLife.54449` Patel et al. 2019 purified Saccharomyces cerevisiae RSC through tagged Sth1, described RSC as 17 proteins with two Rsc8 copies and either Rsc1 or Rsc2, and used cryo-EM and crosslinking mass spectrometry to assign RSC subunit architecture.
Arp9 RSC Arp module subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	ARP9	UNKNOWN	Actin-related-protein constituent of the RSC Arp module. `DOI:10.7554/eLife.54449` Patel et al. 2019 purified Saccharomyces cerevisiae RSC through tagged Sth1, described RSC as 17 proteins with two Rsc8 copies and either Rsc1 or Rsc2, and used cryo-EM and crosslinking mass spectrometry to assign RSC subunit architecture.
Rtt102 RSC Arp module subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	RTT102	UNKNOWN	Constituent of the RSC Arp module with Arp7 and Arp9. `DOI:10.7554/eLife.54449` Patel et al. 2019 purified Saccharomyces cerevisiae RSC through tagged Sth1, described RSC as 17 proteins with two Rsc8 copies and either Rsc1 or Rsc2, and used cryo-EM and crosslinking mass spectrometry to assign RSC subunit architecture.
Npl6 RSC arm lobe subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	NPL6	UNKNOWN	Yeast-conserved constituent that completes the RSC arm lobe. `DOI:10.7554/eLife.54449` Patel et al. 2019 purified Saccharomyces cerevisiae RSC through tagged Sth1, described RSC as 17 proteins with two Rsc8 copies and either Rsc1 or Rsc2, and used cryo-EM and crosslinking mass spectrometry to assign RSC subunit architecture.
Htl1 RSC subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	HTL1	UNKNOWN	RSC-specific scaffold constituent of the body-lobe helical bundle. `DOI:10.7554/eLife.54449` Patel et al. 2019 purified Saccharomyces cerevisiae RSC through tagged Sth1, described RSC as 17 proteins with two Rsc8 copies and either Rsc1 or Rsc2, and used cryo-EM and crosslinking mass spectrometry to assign RSC subunit architecture.
Ldb7 RSC subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	LDB7	UNKNOWN	RSC-specific scaffold constituent assigned in the cryo-EM core. `DOI:10.7554/eLife.54449` Patel et al. 2019 purified Saccharomyces cerevisiae RSC through tagged Sth1, described RSC as 17 proteins with two Rsc8 copies and either Rsc1 or Rsc2, and used cryo-EM and crosslinking mass spectrometry to assign RSC subunit architecture.
Rsc1/Rsc2 RSC isoform subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	RSC1, RSC2	UNKNOWN	Bromodomain- and BAH-domain-containing RSC-specific paralog slot supplied by either Rsc1 or Rsc2. `DOI:10.7554/eLife.54449` Patel et al. 2019 purified Saccharomyces cerevisiae RSC through tagged Sth1, described RSC as 17 proteins with two Rsc8 copies and either Rsc1 or Rsc2, and used cryo-EM and crosslinking mass spectrometry to assign RSC subunit architecture.
Rsc3 RSC tail subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	RSC3	UNKNOWN	RSC-specific tail-module constituent paired with Rsc30. `DOI:10.7554/eLife.54449` Patel et al. 2019 purified Saccharomyces cerevisiae RSC through tagged Sth1, described RSC as 17 proteins with two Rsc8 copies and either Rsc1 or Rsc2, and used cryo-EM and crosslinking mass spectrometry to assign RSC subunit architecture.
Rsc30 RSC tail subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	RSC30	UNKNOWN	RSC-specific tail-module constituent paired with Rsc3. `DOI:10.7554/eLife.54449` Patel et al. 2019 purified Saccharomyces cerevisiae RSC through tagged Sth1, described RSC as 17 proteins with two Rsc8 copies and either Rsc1 or Rsc2, and used cryo-EM and crosslinking mass spectrometry to assign RSC subunit architecture.
Rsc4 RSC head subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	RSC4	UNKNOWN	Bromodomain-containing RSC-specific constituent of the head lobe. `DOI:10.7554/eLife.54449` Patel et al. 2019 purified Saccharomyces cerevisiae RSC through tagged Sth1, described RSC as 17 proteins with two Rsc8 copies and either Rsc1 or Rsc2, and used cryo-EM and crosslinking mass spectrometry to assign RSC subunit architecture.
Rsc58 RSC head/body subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	RSC58	UNKNOWN	Bromodomain-containing RSC-specific constituent that spans the head and body lobes. `DOI:10.7554/eLife.54449` Patel et al. 2019 purified Saccharomyces cerevisiae RSC through tagged Sth1, described RSC as 17 proteins with two Rsc8 copies and either Rsc1 or Rsc2, and used cryo-EM and crosslinking mass spectrometry to assign RSC subunit architecture.

Taxonomic distribution

NCBITaxon:4932 Saccharomyces cerevisiae — COMMON: Budding yeast is the organism from which Patel et al. 2019 purified RSC through tagged Sth1 for cryo-EM and crosslinking mass-spectrometry architecture studies. [DOI:10.7554/eLife.54449]

Canonical examples

NCBITaxon:4932 Saccharomyces cerevisiae — Patel et al. 2019 resolved Saccharomyces cerevisiae RSC into a rigid tripartite core plus flexible ATPase and tail lobes. [DOI:10.7554/eLife.54449]

Functions

chromatin remodeling GO:0006338 — ATP-dependent remodeling of nucleosome positions and histone-DNA contacts that changes chromatin architecture.
- GO:0006338 GO:0006338 is the Gene Ontology biological-process term for chromatin remodeling.
- GO:0016586 Gene Ontology models the RSC-type complex as capable of chromatin remodeling.
- PMID:8980231 Cairns et al. 1996 isolated RSC as an essential and abundant chromatin-remodeling complex.

Mechanism graphs

RSC supports ATP-dependent chromatin remodeling (FUNCTION)

In Saccharomyces cerevisiae, the Sth1 ATPase and accessory RSC subunits assemble into an ATP-dependent remodeler that engages nucleosomes through the core and Arp-module lobes.

Subject	Predicate	Object	Evidence
Sth1 RSC ATPase subunit	contributes to	RSC-type complex	`DOI:10.7554/eLife.54449` Patel et al. 2019 assign Sth1 to the RSC core and Arp-module architecture.
RSC-type complex	supports	chromatin remodeling	`GO:0006338` GO:0006338 lists GO:0016586 as a cellular component capable of chromatin remodeling.

Discussions

CURATION_TODO (OPEN): Resolve exact source-neutral family groundings for the curated budding-yeast RSC constituents.

Evidence

GO:0016586 Gene Ontology cellular-component term for RSC-type complex and its PBAF, Polybromo- and BAF containing, and SWI/SNF complex B exact synonyms.
GO:0070603 Gene Ontology cellular-component parent term for SWI/SNF superfamily-type complexes.
GO:0006338 Gene Ontology biological-process term for chromatin remodeling.
PMID:8980231 PubMed identifier for Cairns et al. 1996, the original RSC chromatin-remodeling-complex paper cited by GO:0016586.
DOI:10.1016/s0092-8674(00)81820-6 DOI for Cairns et al. 1996, 'RSC, an essential, abundant chromatin-remodeling complex', verified through NCBI E-utilities.
PMID:31886770 PubMed identifier for Patel et al. 2019, the budding-yeast RSC cryo-EM and crosslinking mass-spectrometry architecture paper.
DOI:10.7554/eLife.54449 DOI for Patel et al. 2019, 'Architecture of the chromatin remodeler RSC and insights into its nucleosome engagement', verified through NCBI E-utilities.

Curation history

2026-09-26T08:20:09Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-09-26T08:20:51Z codex · EXPANDED_RECORD — Added RSC exact synonymy, SWI/SNF-superfamily parentage, 16 budding-yeast constituent rows, yeast scope, chromatin-remodeling function, GO/PubMed/DOI evidence, a nonmechanistic function graph, and a subunit-grounding TODO.

Source: data/structures/other/rsc_type_complex.yaml