Set1C/COMPASS complex

GO:0048188 · Other · Multiprotein complex · Proposed

A conserved protein complex that catalyzes methylation of histone H3. In Saccharomyces the complex contains Shg1p, Sdc1p, Swd1p, Swd2p, Swd3p, Spp1p, Bre2p, and the trithorax-related Set1p; in mammals it contains the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30. [GO:0048188]

Synonyms: COMPASS complex; Set1C; Set1/COMPASS complex

UniProt location names: UniProt Consortium, CC BY 4.0. Reference label and route sources.

Components

Component	Type	Part of / acts on	Grounding	Genes	Essential	Role
Shg1 COMPASS subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	SHG1	UNKNOWN	Protein constituent of the budding-yeast Set1C/COMPASS histone H3K4 methyltransferase complex. `GO:0048188` GO:0048188 defines the Saccharomyces Set1C/COMPASS complex as containing Shg1p.
Sdc1 COMPASS subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	SDC1	UNKNOWN	Protein constituent of the budding-yeast Set1C/COMPASS histone H3K4 methyltransferase complex. `GO:0048188` GO:0048188 defines the Saccharomyces Set1C/COMPASS complex as containing Sdc1p.
Swd1 COMPASS subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	SWD1	UNKNOWN	WD-repeat protein constituent of the budding-yeast Set1C/COMPASS complex. `GO:0048188` GO:0048188 defines the Saccharomyces Set1C/COMPASS complex as containing Swd1p.
Swd2 COMPASS subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	SWD2	UNKNOWN	WD-repeat protein constituent of the budding-yeast Set1C/COMPASS complex. `GO:0048188` GO:0048188 defines the Saccharomyces Set1C/COMPASS complex as containing Swd2p.
Swd3 COMPASS subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	SWD3	UNKNOWN	WD-repeat protein constituent of the budding-yeast Set1C/COMPASS complex. `GO:0048188` GO:0048188 defines the Saccharomyces Set1C/COMPASS complex as containing Swd3p.
Spp1 COMPASS subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	SPP1	UNKNOWN	Protein constituent of the budding-yeast Set1C/COMPASS histone H3K4 methyltransferase complex. `GO:0048188` GO:0048188 defines the Saccharomyces Set1C/COMPASS complex as containing Spp1p.
Bre2 COMPASS subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	BRE2	UNKNOWN	Ash2-related constituent of the budding-yeast Set1C/COMPASS complex. `GO:0048188` GO:0048188 defines the Saccharomyces Set1C/COMPASS complex as containing Bre2p.
Set1 COMPASS catalytic subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	SET1	UNKNOWN	Trithorax-related SET-domain catalytic constituent of the budding-yeast Set1C/COMPASS complex. `GO:0048188` GO:0048188 defines the Saccharomyces Set1C/COMPASS complex as containing Set1p.

Taxonomic distribution

NCBITaxon:4932 Saccharomyces cerevisiae — COMMON: Budding yeast is the organism in which GO:0048188 defines Set1C/COMPASS as containing Shg1p, Sdc1p, Swd1p, Swd2p, Swd3p, Spp1p, Bre2p and Set1p. [GO:0048188]

Canonical examples

NCBITaxon:4932 Saccharomyces cerevisiae — Miller et al. 2001 named the budding-yeast COMPASS complex as proteins associated with the trithorax-related Set1 SET-domain protein. [DOI:10.1073/pnas.231473398]

Functions

histone H3K4 methyltransferase activity GO:0042800 — Set1C/COMPASS catalyzes methylation of lysine 4 on histone H3.
- GO:0042800 GO:0042800 is the Gene Ontology molecular-function term for histone H3K4 methyltransferase activity.
- GO:0048188 GO:0048188 defines Set1C/COMPASS as catalyzing methylation of histone H3.
- DOI:10.1093/emboj/20.24.7137 Roguev et al. 2001 reported that the Saccharomyces cerevisiae Set1 complex methylates histone H3 lysine 4.

Mechanism graphs

Set1C/COMPASS carries yeast histone H3K4 methylation (FUNCTION)

In Saccharomyces cerevisiae, Shg1p, Sdc1p, Swd1p, Swd2p, Swd3p, Spp1p, Bre2p and Set1p form Set1C/COMPASS, a histone H3 lysine-4 methyltransferase complex.

Subject	Predicate	Object	Evidence
Shg1 COMPASS subunit	contributes to	Set1C/COMPASS complex	`GO:0048188` GO:0048188 defines this protein as a Saccharomyces Set1C/COMPASS constituent.
Sdc1 COMPASS subunit	contributes to	Set1C/COMPASS complex	`GO:0048188` GO:0048188 defines this protein as a Saccharomyces Set1C/COMPASS constituent.
Swd1 COMPASS subunit	contributes to	Set1C/COMPASS complex	`GO:0048188` GO:0048188 defines this protein as a Saccharomyces Set1C/COMPASS constituent.
Swd2 COMPASS subunit	contributes to	Set1C/COMPASS complex	`GO:0048188` GO:0048188 defines this protein as a Saccharomyces Set1C/COMPASS constituent.
Swd3 COMPASS subunit	contributes to	Set1C/COMPASS complex	`GO:0048188` GO:0048188 defines this protein as a Saccharomyces Set1C/COMPASS constituent.
Spp1 COMPASS subunit	contributes to	Set1C/COMPASS complex	`GO:0048188` GO:0048188 defines this protein as a Saccharomyces Set1C/COMPASS constituent.
Bre2 COMPASS subunit	contributes to	Set1C/COMPASS complex	`GO:0048188` GO:0048188 defines this protein as a Saccharomyces Set1C/COMPASS constituent.
Set1 COMPASS catalytic subunit	contributes to	Set1C/COMPASS complex	`GO:0048188` GO:0048188 defines this protein as a Saccharomyces Set1C/COMPASS constituent.
Set1C/COMPASS complex	enables	histone H3K4 methyltransferase activity	`DOI:10.1093/emboj/20.24.7137` Roguev et al. 2001 reported histone H3 lysine-4 methylation by the Saccharomyces Set1 complex.

Discussions

CURATION_TODO (OPEN): Resolve exact source-neutral family groundings for the Set1C/COMPASS complex constituents. GO:0048188 supplied the Saccharomyces gene-name-based component classes, but this pass did not verify exact source-neutral InterPro, Pfam, NCBIfam or UniProt family CURIEs that should be reused across fungal Set1C/COMPASS records.

Evidence

GO:0048188 Gene Ontology cellular-component term for Set1C/COMPASS complex and its COMPASS complex, Set1C and Set1/COMPASS complex exact synonyms.
GO:0035097 Gene Ontology cellular-component parent term for histone methyltransferase complexes.
GO:0042800 Gene Ontology molecular-function term for histone H3K4 methyltransferase activity.
PMID:11687631 PubMed identifier for Miller et al. 2001, the original yeast COMPASS paper.
DOI:10.1073/pnas.231473398 DOI for Miller et al. 2001, 'COMPASS: a complex of proteins associated with a trithorax-related SET domain protein', verified through NCBI E-utilities.
PMID:11742990 PubMed identifier for Roguev et al. 2001, the Saccharomyces Set1 complex H3K4 methyltransferase paper.
DOI:10.1093/emboj/20.24.7137 DOI for Roguev et al. 2001, 'The Saccharomyces cerevisiae Set1 complex includes an Ash2 homologue and methylates histone 3 lysine 4', verified through NCBI E-utilities.
PMID:11805083 PubMed identifier for Krogan et al. 2002, the COMPASS H3K4 methyltransferase and telomeric-silencing paper cited by GO:0048188.
DOI:10.1074/jbc.C200023200 DOI for Krogan et al. 2002, 'COMPASS, a histone H3 (Lysine 4) methyltransferase required for telomeric silencing of gene expression', verified through NCBI E-utilities.

Curation history

2026-09-26T06:52:25Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-09-26T06:53:28Z codex · EXPANDED_RECORD — Added Set1C/COMPASS exact synonymy, histone-methyltransferase-complex parentage, eight budding-yeast constituent rows, yeast scope, histone H3K4 methyltransferase activity, GO/PubMed/DOI evidence, a nonmechanistic function graph, and a COMPASS subunit-grounding TODO.
2026-09-26T06:53:59Z codex · NARROWED_CANONICAL_EXAMPLE_NOTE — Narrowed the budding-yeast canonical example note to the Miller 2001 COMPASS naming paper cited by that row; the Roguev 2001 H3K4 methyltransferase evidence remains attached to the function.

Source: data/structures/other/set1c_compass_complex.yaml