SHREC complex

GO:0070824 · Other · Multiprotein complex · Proposed

A histone deacetylase complex that contains a core of four proteins -- Clr1, Clr2, Clr3, and Mit1 in fission yeast -- and localizes to all heterochromatic regions in the genome as well as some euchromatic sites. The complex is involved in regulating nucleosome positioning to assemble higher-order chromatin structures. [GO:0070824]

Synonyms: Snf2/HDAC containing repressor complex; Snf2/Hdac repressive complex

UniProt location names: UniProt Consortium, CC BY 4.0. Reference label and route sources.

Components

Component	Type	Part of / acts on	Grounding	Essential	Role
Clr1 SHREC subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	UNKNOWN	Protein constituent of the fission-yeast SHREC core complex. `GO:0070824` GO:0070824 defines the fission-yeast SHREC complex as containing core Clr1, Clr2, Clr3 and Mit1 proteins. `DOI:10.1016/j.cell.2006.12.035` Sugiyama et al. 2007 described SHREC as a fission-yeast core quartet that includes Clr1.
Clr2 SHREC subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	UNKNOWN	Protein constituent of the fission-yeast SHREC core complex. `GO:0070824` GO:0070824 defines the fission-yeast SHREC complex as containing core Clr1, Clr2, Clr3 and Mit1 proteins. `DOI:10.1016/j.cell.2006.12.035` Sugiyama et al. 2007 described SHREC as a fission-yeast core quartet that includes Clr2.
Clr3 SHREC histone deacetylase subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	UNKNOWN	Histone deacetylase constituent of the fission-yeast SHREC core complex. `GO:0070824` GO:0070824 defines the fission-yeast SHREC complex as containing core Clr1, Clr2, Clr3 and Mit1 proteins. `DOI:10.1016/j.cell.2006.12.035` Sugiyama et al. 2007 identified Clr3 as the SHREC histone deacetylase associated with heterochromatic transcriptional gene silencing.
Mit1 SHREC SNF2-family subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	UNKNOWN	SNF2-family chromatin-remodeling-factor constituent of the fission-yeast SHREC core complex. `GO:0070824` GO:0070824 defines the fission-yeast SHREC complex as containing core Clr1, Clr2, Clr3 and Mit1 proteins. `DOI:10.1016/j.cell.2006.12.035` Sugiyama et al. 2007 identified Mit1 as the SHREC SNF2 chromatin-remodeling factor homolog associated with heterochromatic transcriptional gene silencing.

Taxonomic distribution

NCBITaxon:4896 Schizosaccharomyces pombe — COMMON: Fission yeast is the organism in which GO:0070824 defines the SHREC complex as a four-protein histone deacetylase complex containing Clr1, Clr2, Clr3 and Mit1. [GO:0070824]

Canonical examples

NCBITaxon:4896 Schizosaccharomyces pombe — Sugiyama et al. 2007 characterized the fission-yeast SHREC core quartet and linked its Clr3 and Mit1 activities to heterochromatic transcriptional silencing. [DOI:10.1016/j.cell.2006.12.035]

Functions

histone deacetylase activity GO:0004407 — The SHREC complex is a fission-yeast histone deacetylase complex containing the Clr3 histone deacetylase.
- GO:0070824 GO:0070824 defines SHREC as a histone deacetylase complex containing Clr3.
- GO:0004407 GO:0004407 is the Gene Ontology molecular-function term for histone deacetylase activity.
- DOI:10.1016/j.cell.2006.12.035 Sugiyama et al. 2007 identified Clr3 as the histone deacetylase effector in fission-yeast SHREC.
chromatin remodeling GO:0006338 — SHREC regulates nucleosome positioning through the Mit1 SNF2-family remodeling factor to assemble higher-order heterochromatin.
- GO:0070824 GO:0070824 defines SHREC as involved in regulating nucleosome positioning to assemble higher-order chromatin structures.
- GO:0006338 GO:0006338 is the Gene Ontology biological-process term for chromatin remodeling.
- DOI:10.1016/j.cell.2006.12.035 Sugiyama et al. 2007 identified Mit1 as the SHREC SNF2-family chromatin-remodeling factor homolog and connected SHREC with nucleosome positioning.

Mechanism graphs

SHREC couples deacetylation and remodeling in fission yeast (FUNCTION)

In Schizosaccharomyces pombe, Clr1, Clr2, Clr3 and Mit1 form the SHREC complex that couples histone deacetylase and SNF2-family remodeling activities during heterochromatic transcriptional silencing.

Subject	Predicate	Object	Evidence
Clr1 SHREC subunit	contributes to	SHREC complex	`GO:0070824` GO:0070824 defines Clr1 as a SHREC complex core protein. `DOI:10.1016/j.cell.2006.12.035` Sugiyama et al. 2007 described SHREC as a core quartet that includes Clr1.
Clr2 SHREC subunit	contributes to	SHREC complex	`GO:0070824` GO:0070824 defines Clr2 as a SHREC complex core protein. `DOI:10.1016/j.cell.2006.12.035` Sugiyama et al. 2007 described SHREC as a core quartet that includes Clr2.
Clr3 SHREC histone deacetylase subunit	contributes to	SHREC complex	`GO:0070824` GO:0070824 defines Clr3 as a SHREC complex core protein. `DOI:10.1016/j.cell.2006.12.035` Sugiyama et al. 2007 connected SHREC effector activity to its Clr3 histone deacetylase.
Mit1 SHREC SNF2-family subunit	contributes to	SHREC complex	`GO:0070824` GO:0070824 defines Mit1 as a SHREC complex core protein. `DOI:10.1016/j.cell.2006.12.035` Sugiyama et al. 2007 connected SHREC effector activity to its Mit1 SNF2-family remodeling factor homolog.
SHREC complex	supports	histone deacetylase activity	`GO:0070824` GO:0070824 defines SHREC as a histone deacetylase complex. `GO:0004407` GO:0004407 is the molecular-function term for histone deacetylase activity. `DOI:10.1016/j.cell.2006.12.035` Sugiyama et al. 2007 identified Clr3 as the SHREC histone deacetylase.
SHREC complex	supports	chromatin remodeling	`GO:0070824` GO:0070824 defines SHREC as involved in regulating nucleosome positioning. `GO:0006338` GO:0006338 is the biological-process term for chromatin remodeling. `DOI:10.1016/j.cell.2006.12.035` Sugiyama et al. 2007 connected SHREC with nucleosome positioning and Mit1-associated SNF2-family remodeling activity.

Discussions

CURATION_TODO (OPEN): Resolve exact source-neutral family groundings for the Clr1, Clr2, Clr3 and Mit1 SHREC constituents. GO:0070824 and Sugiyama et al. 2007 define fission-yeast Clr1, Clr2, Clr3 and Mit1 as SHREC core constituents. Exact cross-eukaryotic InterPro, Pfam, NCBIfam or UniProt family boundaries for these SHREC subunit classes need narrower curation before the component labels can be grounded.

Evidence

GO:0070824 Gene Ontology cellular-component term for the SHREC complex.
GO:0016581 Gene Ontology cellular-component parent term for NuRD complexes.
GO:0004407 Gene Ontology molecular-function term for histone deacetylase activity.
GO:0006338 Gene Ontology biological-process term for chromatin remodeling.
PMID:17289569 PubMed identifier for Sugiyama et al. 2007, the Cell SHREC paper cited by GO:0070824.
DOI:10.1016/j.cell.2006.12.035 DOI for Sugiyama et al. 2007, 'SHREC, an effector complex for heterochromatic transcriptional silencing', verified through NCBI E-utilities.

Curation history

2026-09-26T05:23:19Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-09-26T05:26:01Z codex · EXPANDED_RECORD — Added SHREC exact synonymy and NuRD parentage, Clr1/Clr2/Clr3/Mit1 constituent rows, fission-yeast scope, histone deacetylase and chromatin-remodeling functions, GO/PubMed/DOI evidence, a nonmechanistic function graph, and a SHREC subunit-grounding TODO.

Source: data/structures/other/shrec_complex.yaml