Snt2C complex

GO:0070211 · Other · Multiprotein complex · Proposed

A histone deacetylase complex that is part of the chromatin remodeling machinery. In Saccharomyces cerevisiae this complex contains Snt2p, Ecm5p and Rpd3p. [GO:0070211]

Synonyms: Snt2 complex

Part of: GO:0000785 — chromatin (no local record)

UniProt location names: UniProt Consortium, CC BY 4.0. Reference label and route sources.

Components

Component	Type	Part of / acts on	Grounding	Genes	Essential	Role
Snt2 Snt2C subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	SNT2	UNKNOWN	SANT-domain constituent that gives the budding-yeast Snt2C histone deacetylase complex its name. `GO:0070211` GO:0070211 defines the S. cerevisiae Snt2C complex as containing Snt2p. `DOI:10.1186/gb-2008-9-11-r167` Shevchenko et al. 2008 listed SNT2 under the Snt2 complex and reported validating the three-member complex by tagging Snt2.
Ecm5 Snt2C subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	ECM5	UNKNOWN	JmjC/PHD-finger constituent of the budding-yeast Snt2C histone deacetylase complex. `GO:0070211` GO:0070211 defines the S. cerevisiae Snt2C complex as containing Ecm5p. `DOI:10.1186/gb-2008-9-11-r167` Shevchenko et al. 2008 listed ECM5 under the Snt2 complex and described Ecm5p as the other Snt2C subunit besides Snt2p and Rpd3p.
Rpd3 Snt2C deacetylase subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	RPD3	UNKNOWN	Histone deacetylase constituent shared with other Rpd3-containing budding-yeast HDAC complexes. `GO:0070211` GO:0070211 defines the S. cerevisiae Snt2C complex as containing Rpd3p. `DOI:10.1186/gb-2008-9-11-r167` Shevchenko et al. 2008 found Snt2C in an Rpd3-TAP pulldown and listed RPD3 under the Snt2 complex.

Taxonomic distribution

NCBITaxon:4932 Saccharomyces cerevisiae — COMMON: Budding yeast is the organism in which GO:0070211 defines the Snt2C complex as a three-subunit Rpd3-containing histone deacetylase complex. [GO:0070211]

Canonical examples

NCBITaxon:4932 Saccharomyces cerevisiae — Shevchenko et al. 2008 found the Snt2C complex in a budding-yeast Rpd3-TAP pulldown and validated the complex by tagging Snt2. [DOI:10.1186/gb-2008-9-11-r167]

Functions

histone deacetylase activity GO:0004407 — The Snt2C complex is an Rpd3-containing histone deacetylase complex.
- GO:0070211 GO:0070211 defines Snt2C as a histone deacetylase complex containing Rpd3p.
- GO:0004407 GO:0004407 is the Gene Ontology molecular-function term for histone deacetylase activity.
- DOI:10.1186/gb-2008-9-11-r167 Shevchenko et al. 2008 found Snt2C as one of two new Rpd3-containing complexes in budding yeast Chromatin Central.

Mechanism graphs

Snt2C carries yeast histone deacetylase activity (FUNCTION)

In Saccharomyces cerevisiae, Snt2p, Ecm5p and Rpd3p form the Snt2C histone deacetylase complex.

Subject	Predicate	Object	Evidence
Snt2 Snt2C subunit	contributes to	Snt2C complex	`GO:0070211` GO:0070211 defines Snt2p as an Snt2C complex constituent.
Ecm5 Snt2C subunit	contributes to	Snt2C complex	`GO:0070211` GO:0070211 defines Ecm5p as an Snt2C complex constituent.
Rpd3 Snt2C deacetylase subunit	contributes to	Snt2C complex	`GO:0070211` GO:0070211 defines Rpd3p as an Snt2C complex constituent. `DOI:10.1186/gb-2008-9-11-r167` Shevchenko et al. 2008 found Snt2C in an Rpd3-TAP pulldown.
Snt2C complex	supports	histone deacetylase activity	`GO:0070211` GO:0070211 defines Snt2C as a histone deacetylase complex. `GO:0004407` GO:0004407 is the molecular-function term for histone deacetylase activity.

Discussions

CURATION_TODO (OPEN): Resolve exact source-neutral family groundings for the Snt2C constituents. GO:0070211 defines the budding-yeast Snt2p, Ecm5p and Rpd3p proteins as Snt2C complex constituents. Exact cross-eukaryotic InterPro, Pfam, NCBIfam or UniProt family boundaries for these Snt2C subunit classes need narrower curation before these component labels can be grounded.

Evidence

GO:0070211 Gene Ontology cellular-component term for the Snt2C complex.
GO:0000118 Gene Ontology cellular-component parent term for histone deacetylase complexes.
GO:0000785 — chromatin Gene Ontology cellular-component term for chromatin.
GO:0004407 Gene Ontology molecular-function term for histone deacetylase activity.
PMID:19040720 PubMed identifier for Shevchenko et al. 2008, the Genome Biology Chromatin Central paper cited by GO:0070211.
DOI:10.1186/gb-2008-9-11-r167 DOI for Shevchenko et al. 2008, 'Chromatin Central: towards the comparative proteome by accurate mapping of the yeast proteomic environment', verified through NCBI E-utilities.

Curation history

2026-09-26T04:02:53Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-09-26T04:04:32Z codex · EXPANDED_RECORD — Added Snt2 exact synonymy, histone-deacetylase-complex parentage and chromatin parthood, Snt2C constituent rows, budding-yeast scope, histone deacetylase activity, GO/PubMed/DOI evidence, a nonmechanistic function graph, and a Snt2C subunit-grounding TODO.
2026-09-26T04:13:29Z codex · FIX_SNT2_DOMAIN_WORDING — Clarified that Snt2p is the SANT-domain subunit of Snt2C, leaving JmjC-domain wording on Ecm5p.

Source: data/structures/other/snt2c_complex.yaml