SWI/SNF complex

GO:0016514 · Other · Multiprotein complex · Proposed

A SWI/SNF-type complex that contains 8 to 14 proteins, including both conserved (core) and nonconserved components; contains the ATPase product of the yeast SNF2 or mammalian SMARCA4/BAF190A/BRG1 gene, or an ortholog thereof. [GO:0016514]

Synonyms: SWI-SNF complex

UniProt location names: UniProt Consortium, CC BY 4.0. Reference label and route sources.

Components

Component	Type	Part of / acts on	Grounding	Genes	Essential	Role
Snf2 SWI/SNF ATPase subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	SNF2	UNKNOWN	ATPase-containing catalytic constituent of the budding-yeast SWI/SNF remodeler. `DOI:10.1038/s41467-020-17229-x` Wang et al. 2020 purified endogenous Saccharomyces cerevisiae Swi/Snf, described the intact 12-subunit complex, and resolved the Snf2-containing base and Arp-module architecture. `DOI:10.1016/j.celrep.2017.01.058` Dutta et al. 2017 systematically purified wild-type and mutant Saccharomyces cerevisiae Swi/Snf complexes and organized the 12 subunits into Arp, Snf11-Snf12, Snf12-Snf6-Swi3, Taf14-Snf5-Swp82 and Swi1 modules.
Swi1 SWI/SNF core subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	SWI1	UNKNOWN	Conserved base-module scaffold constituent that interacts with Swi3 and other core components. `DOI:10.1038/s41467-020-17229-x` Wang et al. 2020 purified endogenous Saccharomyces cerevisiae Swi/Snf, described the intact 12-subunit complex, and resolved the Snf2-containing base and Arp-module architecture. `DOI:10.1016/j.celrep.2017.01.058` Dutta et al. 2017 systematically purified wild-type and mutant Saccharomyces cerevisiae Swi/Snf complexes and organized the 12 subunits into Arp, Snf11-Snf12, Snf12-Snf6-Swi3, Taf14-Snf5-Swp82 and Swi1 modules.
Swi3 SWI/SNF core subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	SWI3	UNKNOWN	Conserved base-module backbone constituent that helps form the coiled-coil domain. `DOI:10.1038/s41467-020-17229-x` Wang et al. 2020 purified endogenous Saccharomyces cerevisiae Swi/Snf, described the intact 12-subunit complex, and resolved the Snf2-containing base and Arp-module architecture. `DOI:10.1016/j.celrep.2017.01.058` Dutta et al. 2017 systematically purified wild-type and mutant Saccharomyces cerevisiae Swi/Snf complexes and organized the 12 subunits into Arp, Snf11-Snf12, Snf12-Snf6-Swi3, Taf14-Snf5-Swp82 and Swi1 modules.
Snf5 SWI/SNF core subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	SNF5	UNKNOWN	Nucleosome-binding-module constituent of the budding-yeast SWI/SNF base. `DOI:10.1038/s41467-020-17229-x` Wang et al. 2020 purified endogenous Saccharomyces cerevisiae Swi/Snf, described the intact 12-subunit complex, and resolved the Snf2-containing base and Arp-module architecture. `DOI:10.1016/j.celrep.2017.01.058` Dutta et al. 2017 systematically purified wild-type and mutant Saccharomyces cerevisiae Swi/Snf complexes and organized the 12 subunits into Arp, Snf11-Snf12, Snf12-Snf6-Swi3, Taf14-Snf5-Swp82 and Swi1 modules.
Snf6 SWI/SNF core subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	SNF6	UNKNOWN	Yeast-specific core constituent that stabilizes Snf2 binding to the SWI/SNF base module. `DOI:10.1038/s41467-020-17229-x` Wang et al. 2020 purified endogenous Saccharomyces cerevisiae Swi/Snf, described the intact 12-subunit complex, and resolved the Snf2-containing base and Arp-module architecture. `DOI:10.1016/j.celrep.2017.01.058` Dutta et al. 2017 systematically purified wild-type and mutant Saccharomyces cerevisiae Swi/Snf complexes and organized the 12 subunits into Arp, Snf11-Snf12, Snf12-Snf6-Swi3, Taf14-Snf5-Swp82 and Swi1 modules.
Snf12 SWI/SNF core subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	SNF12	UNKNOWN	Coiled-coil and core-module constituent of the budding-yeast SWI/SNF base. `DOI:10.1038/s41467-020-17229-x` Wang et al. 2020 purified endogenous Saccharomyces cerevisiae Swi/Snf, described the intact 12-subunit complex, and resolved the Snf2-containing base and Arp-module architecture. `DOI:10.1016/j.celrep.2017.01.058` Dutta et al. 2017 systematically purified wild-type and mutant Saccharomyces cerevisiae Swi/Snf complexes and organized the 12 subunits into Arp, Snf11-Snf12, Snf12-Snf6-Swi3, Taf14-Snf5-Swp82 and Swi1 modules.
Swp82 SWI/SNF core subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	SWP82	UNKNOWN	Core constituent associated with the nucleosome-binding and preHSA-stabilization modules. `DOI:10.1038/s41467-020-17229-x` Wang et al. 2020 purified endogenous Saccharomyces cerevisiae Swi/Snf, described the intact 12-subunit complex, and resolved the Snf2-containing base and Arp-module architecture. `DOI:10.1016/j.celrep.2017.01.058` Dutta et al. 2017 systematically purified wild-type and mutant Saccharomyces cerevisiae Swi/Snf complexes and organized the 12 subunits into Arp, Snf11-Snf12, Snf12-Snf6-Swi3, Taf14-Snf5-Swp82 and Swi1 modules.
Snf11 SWI/SNF subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	SNF11	UNKNOWN	Mobile constituent of the purified budding-yeast SWI/SNF complex. `DOI:10.1038/s41467-020-17229-x` Wang et al. 2020 purified endogenous Saccharomyces cerevisiae Swi/Snf, described the intact 12-subunit complex, and resolved the Snf2-containing base and Arp-module architecture. `DOI:10.1016/j.celrep.2017.01.058` Dutta et al. 2017 systematically purified wild-type and mutant Saccharomyces cerevisiae Swi/Snf complexes and organized the 12 subunits into Arp, Snf11-Snf12, Snf12-Snf6-Swi3, Taf14-Snf5-Swp82 and Swi1 modules.
Taf14 SWI/SNF subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	TAF14	UNKNOWN	Mobile constituent of the purified budding-yeast SWI/SNF complex. `DOI:10.1038/s41467-020-17229-x` Wang et al. 2020 purified endogenous Saccharomyces cerevisiae Swi/Snf, described the intact 12-subunit complex, and resolved the Snf2-containing base and Arp-module architecture. `DOI:10.1016/j.celrep.2017.01.058` Dutta et al. 2017 systematically purified wild-type and mutant Saccharomyces cerevisiae Swi/Snf complexes and organized the 12 subunits into Arp, Snf11-Snf12, Snf12-Snf6-Swi3, Taf14-Snf5-Swp82 and Swi1 modules.
Arp7 SWI/SNF Arp module subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	ARP7	UNKNOWN	Actin-related-protein constituent of the SWI/SNF Arp module. `DOI:10.1038/s41467-020-17229-x` Wang et al. 2020 purified endogenous Saccharomyces cerevisiae Swi/Snf, described the intact 12-subunit complex, and resolved the Snf2-containing base and Arp-module architecture. `DOI:10.1016/j.celrep.2017.01.058` Dutta et al. 2017 systematically purified wild-type and mutant Saccharomyces cerevisiae Swi/Snf complexes and organized the 12 subunits into Arp, Snf11-Snf12, Snf12-Snf6-Swi3, Taf14-Snf5-Swp82 and Swi1 modules.
Arp9 SWI/SNF Arp module subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	ARP9	UNKNOWN	Actin-related-protein constituent of the SWI/SNF Arp module. `DOI:10.1038/s41467-020-17229-x` Wang et al. 2020 purified endogenous Saccharomyces cerevisiae Swi/Snf, described the intact 12-subunit complex, and resolved the Snf2-containing base and Arp-module architecture. `DOI:10.1016/j.celrep.2017.01.058` Dutta et al. 2017 systematically purified wild-type and mutant Saccharomyces cerevisiae Swi/Snf complexes and organized the 12 subunits into Arp, Snf11-Snf12, Snf12-Snf6-Swi3, Taf14-Snf5-Swp82 and Swi1 modules.
Rtt102 SWI/SNF Arp module subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	RTT102	UNKNOWN	Constituent of the Arp module associated with Arp7 and Arp9. `DOI:10.1038/s41467-020-17229-x` Wang et al. 2020 purified endogenous Saccharomyces cerevisiae Swi/Snf, described the intact 12-subunit complex, and resolved the Snf2-containing base and Arp-module architecture. `DOI:10.1016/j.celrep.2017.01.058` Dutta et al. 2017 systematically purified wild-type and mutant Saccharomyces cerevisiae Swi/Snf complexes and organized the 12 subunits into Arp, Snf11-Snf12, Snf12-Snf6-Swi3, Taf14-Snf5-Swp82 and Swi1 modules.

Taxonomic distribution

NCBITaxon:4932 Saccharomyces cerevisiae — COMMON: Budding yeast is the organism from which Wang et al. 2020 purified endogenous intact 12-subunit Swi/Snf complexes through a tagged Snf6 subunit for cryo-EM structure determination. [DOI:10.1038/s41467-020-17229-x]

Canonical examples

NCBITaxon:4932 Saccharomyces cerevisiae — Wang et al. 2020 solved a cryo-EM structure of Saccharomyces cerevisiae Swi/Snf in a nucleosome-free state and assigned the base and Arp-module organization. [DOI:10.1038/s41467-020-17229-x]

Functions

chromatin remodeling GO:0006338 — ATP-dependent remodeling of histone-DNA contacts that changes chromatin architecture.
- GO:0006338 GO:0006338 is the Gene Ontology biological-process term for chromatin remodeling.
- GO:0016514 Gene Ontology models the SWI/SNF complex as capable of chromatin remodeling.
- DOI:10.1016/j.celrep.2017.01.058 Dutta et al. 2017 assayed how deletion of budding-yeast Swi/Snf subunits changes Snf2 occupancy, nucleosome occupancy and gene expression.

Mechanism graphs

SWI/SNF supports ATP-dependent chromatin remodeling (FUNCTION)

In Saccharomyces cerevisiae, the Snf2 ATPase and accessory Swi/Snf subunits assemble into an ATP-dependent chromatin remodeler that changes nucleosome positioning and histone-DNA contacts.

Subject	Predicate	Object	Evidence
Snf2 SWI/SNF ATPase subunit	contributes to	SWI/SNF complex	`GO:0016514` GO:0016514 defines SWI/SNF complexes as containing a yeast SNF2 or orthologous ATPase gene product.
SWI/SNF complex	supports	chromatin remodeling	`GO:0006338` GO:0006338 lists GO:0016514 as a cellular component capable of chromatin remodeling.

Discussions

CURATION_TODO (OPEN): Resolve exact source-neutral family groundings for the curated budding-yeast SWI/SNF constituents.

Evidence

GO:0016514 Gene Ontology cellular-component term for SWI/SNF complex and its SWI-SNF complex exact synonym.
GO:0070603 Gene Ontology cellular-component parent term for SWI/SNF superfamily-type complexes.
GO:0006338 Gene Ontology biological-process term for chromatin remodeling.
PMID:12672490 PubMed identifier for Martens and Winston 2003, the SWI/SNF review cited in the GO:0016514 term definition.
DOI:10.1016/s0959-437x(03)00022-4 DOI for Martens and Winston 2003, verified through NCBI E-utilities.
PMID:8127913 PubMed identifier for Cairns et al. 1994, the yeast multisubunit SWI/SNF-complex isolation paper.
DOI:10.1073/pnas.91.5.1950 DOI for Cairns et al. 1994, 'A multisubunit complex containing the SWI1/ADR6, SWI2/SNF2, SWI3, SNF5, and SNF6 gene products isolated from yeast', verified through NCBI E-utilities.
PMID:28249159 PubMed identifier for Dutta et al. 2017, the systematic yeast Swi/Snf complex composition and mutant-function paper.
DOI:10.1016/j.celrep.2017.01.058 DOI for Dutta et al. 2017, 'Composition and Function of Mutant Swi/Snf Complexes', verified through NCBI E-utilities.
PMID:32636384 PubMed identifier for Wang et al. 2020, the nucleosome-free budding-yeast Swi/Snf cryo-EM structure paper.
DOI:10.1038/s41467-020-17229-x DOI for Wang et al. 2020, 'Structure of the yeast Swi/Snf complex in a nucleosome free state', verified through NCBI E-utilities.

Curation history

2026-09-26T07:52:49Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-09-26T07:53:41Z codex · EXPANDED_RECORD — Added SWI/SNF exact synonymy, SWI/SNF-superfamily parentage, 12 budding-yeast constituent rows, yeast scope, chromatin-remodeling function, GO/PubMed/DOI evidence, a nonmechanistic function graph, and a subunit-grounding TODO.

Source: data/structures/other/swi_snf_complex.yaml