Swr1 complex

GO:0000812 · Other · Multiprotein complex · Proposed

A multisubunit INO80-type chromatin-remodeling complex that catalyzes ATP-dependent exchange of nucleosomal H2A-H2B dimers for H2AZ-H2B dimers. [DOI:10.1126/science.1090701]

Synonyms: SWR-C; SWR1 complex

Part of: nuclear chromosome (GO:0000228)

UniProt location names: UniProt Consortium, CC BY 4.0. Reference label and route sources.

Components

Component	Type	Part of / acts on	Grounding	Essential	Role
Swr1 SWR-C ATPase subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	UNKNOWN	Swi2/Snf2-related ATPase constituent and scaffold of the budding-yeast SWR-C chromatin remodeling complex. `DOI:10.1074/jbc.M808830200` Wu et al. 2009 describe the yeast SWR1 enzyme as containing the Swr1 ATPase, Swc2, Bdf1, Swc3, Arp6, Swc5, Yaf9, Swc6, Swc7, Rvb1, Rvb2, Arp4, Swc4/Eaf2 and Act1.
Swc2 SWR-C subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	UNKNOWN	Protein constituent of the budding-yeast SWR-C chromatin remodeling complex. `DOI:10.1074/jbc.M808830200` Wu et al. 2009 describe the yeast SWR1 enzyme as containing the Swr1 ATPase, Swc2, Bdf1, Swc3, Arp6, Swc5, Yaf9, Swc6, Swc7, Rvb1, Rvb2, Arp4, Swc4/Eaf2 and Act1.
Bdf1 SWR-C subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	UNKNOWN	Bromodomain-containing protein constituent of the budding-yeast SWR-C chromatin remodeling complex. `DOI:10.1074/jbc.M808830200` Wu et al. 2009 describe the yeast SWR1 enzyme as containing the Swr1 ATPase, Swc2, Bdf1, Swc3, Arp6, Swc5, Yaf9, Swc6, Swc7, Rvb1, Rvb2, Arp4, Swc4/Eaf2 and Act1.
Swc3 SWR-C subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	UNKNOWN	Protein constituent of the budding-yeast SWR-C chromatin remodeling complex. `DOI:10.1074/jbc.M808830200` Wu et al. 2009 describe the yeast SWR1 enzyme as containing the Swr1 ATPase, Swc2, Bdf1, Swc3, Arp6, Swc5, Yaf9, Swc6, Swc7, Rvb1, Rvb2, Arp4, Swc4/Eaf2 and Act1.
Arp6 SWR-C subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	UNKNOWN	Actin-related protein constituent of the budding-yeast SWR-C chromatin remodeling complex. `DOI:10.1074/jbc.M808830200` Wu et al. 2009 describe the yeast SWR1 enzyme as containing the Swr1 ATPase, Swc2, Bdf1, Swc3, Arp6, Swc5, Yaf9, Swc6, Swc7, Rvb1, Rvb2, Arp4, Swc4/Eaf2 and Act1.
Swc5 SWR-C subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	UNKNOWN	Protein constituent of the budding-yeast SWR-C chromatin remodeling complex. `DOI:10.1074/jbc.M808830200` Wu et al. 2009 describe the yeast SWR1 enzyme as containing the Swr1 ATPase, Swc2, Bdf1, Swc3, Arp6, Swc5, Yaf9, Swc6, Swc7, Rvb1, Rvb2, Arp4, Swc4/Eaf2 and Act1.
Yaf9 SWR-C subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	UNKNOWN	Protein constituent of the budding-yeast SWR-C chromatin remodeling complex. `DOI:10.1074/jbc.M808830200` Wu et al. 2009 describe the yeast SWR1 enzyme as containing the Swr1 ATPase, Swc2, Bdf1, Swc3, Arp6, Swc5, Yaf9, Swc6, Swc7, Rvb1, Rvb2, Arp4, Swc4/Eaf2 and Act1.
Swc6 SWR-C subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	UNKNOWN	Protein constituent of the budding-yeast SWR-C chromatin remodeling complex. `DOI:10.1074/jbc.M808830200` Wu et al. 2009 describe the yeast SWR1 enzyme as containing the Swr1 ATPase, Swc2, Bdf1, Swc3, Arp6, Swc5, Yaf9, Swc6, Swc7, Rvb1, Rvb2, Arp4, Swc4/Eaf2 and Act1.
Swc7 SWR-C subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	UNKNOWN	Protein constituent of the budding-yeast SWR-C chromatin remodeling complex. `DOI:10.1074/jbc.M808830200` Wu et al. 2009 describe the yeast SWR1 enzyme as containing the Swr1 ATPase, Swc2, Bdf1, Swc3, Arp6, Swc5, Yaf9, Swc6, Swc7, Rvb1, Rvb2, Arp4, Swc4/Eaf2 and Act1.
Rvb1 SWR-C subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	UNKNOWN	RuvB-like AAA+ ATPase constituent of the budding-yeast SWR-C chromatin remodeling complex. `DOI:10.1074/jbc.M808830200` Wu et al. 2009 describe the yeast SWR1 enzyme as containing the Swr1 ATPase, Swc2, Bdf1, Swc3, Arp6, Swc5, Yaf9, Swc6, Swc7, Rvb1, Rvb2, Arp4, Swc4/Eaf2 and Act1.
Rvb2 SWR-C subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	UNKNOWN	RuvB-like AAA+ ATPase constituent of the budding-yeast SWR-C chromatin remodeling complex. `DOI:10.1074/jbc.M808830200` Wu et al. 2009 describe the yeast SWR1 enzyme as containing the Swr1 ATPase, Swc2, Bdf1, Swc3, Arp6, Swc5, Yaf9, Swc6, Swc7, Rvb1, Rvb2, Arp4, Swc4/Eaf2 and Act1.
Arp4 SWR-C subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	UNKNOWN	Actin-related protein constituent of the budding-yeast SWR-C chromatin remodeling complex. `DOI:10.1074/jbc.M808830200` Wu et al. 2009 describe the yeast SWR1 enzyme as containing the Swr1 ATPase, Swc2, Bdf1, Swc3, Arp6, Swc5, Yaf9, Swc6, Swc7, Rvb1, Rvb2, Arp4, Swc4/Eaf2 and Act1.
Swc4 SWR-C subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	UNKNOWN	Eaf2/Swc4 constituent of the budding-yeast SWR-C chromatin remodeling complex. `DOI:10.1074/jbc.M808830200` Wu et al. 2009 describe the yeast SWR1 enzyme as containing the Swr1 ATPase, Swc2, Bdf1, Swc3, Arp6, Swc5, Yaf9, Swc6, Swc7, Rvb1, Rvb2, Arp4, Swc4/Eaf2 and Act1.
Act1 SWR-C actin constituent	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	UNKNOWN	Actin constituent of the budding-yeast SWR-C chromatin remodeling complex. `DOI:10.1074/jbc.M808830200` Wu et al. 2009 describe the yeast SWR1 enzyme as containing the Swr1 ATPase, Swc2, Bdf1, Swc3, Arp6, Swc5, Yaf9, Swc6, Swc7, Rvb1, Rvb2, Arp4, Swc4/Eaf2 and Act1.

Taxonomic distribution

NCBITaxon:4932 Saccharomyces cerevisiae — COMMON: Budding yeast is the organism in which GO:0000812 defines the Swr1 complex as an H2AZ-depositing chromatin remodeling complex. [GO:0000812]

Canonical examples

NCBITaxon:4932 Saccharomyces cerevisiae — Mizuguchi et al. 2004 purified the budding-yeast SWR1 complex and showed that it catalyzes ATP-dependent exchange of nucleosomal H2A-H2B for H2AZ-H2B dimers. [DOI:10.1126/science.1090701]

Functions

ATP-dependent H2AZ histone chaperone activity GO:0140849 — The SWR1 complex catalyzes ATP-dependent replacement of canonical H2A-H2B dimers with H2AZ-H2B dimers in nucleosomes.
- GO:0140849 GO:0140849 is the Gene Ontology molecular-function term for ATP-dependent H2AZ histone chaperone activity.
- DOI:10.1126/science.1090701 Mizuguchi et al. 2004 biochemically characterized ATP-driven H2AZ exchange by the budding-yeast SWR1 complex.
chromatin remodeling GO:0006338 — The Swr1 complex is an INO80-type chromatin-remodeling complex that deposits H2AZ into chromatin.
- GO:0006338 GO:0006338 is the Gene Ontology biological-process term for chromatin remodeling.
- GO:0000812 GO:0000812 defines the Swr1 complex as a multisubunit protein complex involved in chromatin remodeling.

Mechanism graphs

SWR-C carries yeast ATP-dependent H2AZ exchange (FUNCTION)

In Saccharomyces cerevisiae, Swr1, Swc2, Bdf1, Swc3, Arp6, Swc5, Yaf9, Swc6, Swc7, Rvb1, Rvb2, Arp4, Swc4 and Act1 form the SWR-C chromatin-remodeling complex.

Subject	Predicate	Object	Evidence
Swr1 SWR-C ATPase subunit	contributes to	Swr1 complex	`DOI:10.1074/jbc.M808830200` Wu et al. 2009 list this protein among the fourteen subunits of the yeast SWR1 enzyme.
Swc2 SWR-C subunit	contributes to	Swr1 complex	`DOI:10.1074/jbc.M808830200` Wu et al. 2009 list this protein among the fourteen subunits of the yeast SWR1 enzyme.
Bdf1 SWR-C subunit	contributes to	Swr1 complex	`DOI:10.1074/jbc.M808830200` Wu et al. 2009 list this protein among the fourteen subunits of the yeast SWR1 enzyme.
Swc3 SWR-C subunit	contributes to	Swr1 complex	`DOI:10.1074/jbc.M808830200` Wu et al. 2009 list this protein among the fourteen subunits of the yeast SWR1 enzyme.
Arp6 SWR-C subunit	contributes to	Swr1 complex	`DOI:10.1074/jbc.M808830200` Wu et al. 2009 list this protein among the fourteen subunits of the yeast SWR1 enzyme.
Swc5 SWR-C subunit	contributes to	Swr1 complex	`DOI:10.1074/jbc.M808830200` Wu et al. 2009 list this protein among the fourteen subunits of the yeast SWR1 enzyme.
Yaf9 SWR-C subunit	contributes to	Swr1 complex	`DOI:10.1074/jbc.M808830200` Wu et al. 2009 list this protein among the fourteen subunits of the yeast SWR1 enzyme.
Swc6 SWR-C subunit	contributes to	Swr1 complex	`DOI:10.1074/jbc.M808830200` Wu et al. 2009 list this protein among the fourteen subunits of the yeast SWR1 enzyme.
Swc7 SWR-C subunit	contributes to	Swr1 complex	`DOI:10.1074/jbc.M808830200` Wu et al. 2009 list this protein among the fourteen subunits of the yeast SWR1 enzyme.
Rvb1 SWR-C subunit	contributes to	Swr1 complex	`DOI:10.1074/jbc.M808830200` Wu et al. 2009 list this protein among the fourteen subunits of the yeast SWR1 enzyme.
Rvb2 SWR-C subunit	contributes to	Swr1 complex	`DOI:10.1074/jbc.M808830200` Wu et al. 2009 list this protein among the fourteen subunits of the yeast SWR1 enzyme.
Arp4 SWR-C subunit	contributes to	Swr1 complex	`DOI:10.1074/jbc.M808830200` Wu et al. 2009 list this protein among the fourteen subunits of the yeast SWR1 enzyme.
Swc4 SWR-C subunit	contributes to	Swr1 complex	`DOI:10.1074/jbc.M808830200` Wu et al. 2009 list this protein among the fourteen subunits of the yeast SWR1 enzyme.
Act1 SWR-C actin constituent	contributes to	Swr1 complex	`DOI:10.1074/jbc.M808830200` Wu et al. 2009 list this protein among the fourteen subunits of the yeast SWR1 enzyme.
Swr1 complex	supports	ATP-dependent H2AZ histone chaperone activity	`DOI:10.1126/science.1090701` Mizuguchi et al. 2004 established ATP-driven histone H2AZ exchange by budding-yeast SWR1. `GO:0140849` GO:0140849 denotes ATP-dependent H2AZ histone chaperone activity.
ATP-dependent H2AZ histone chaperone activity	contributes to	chromatin remodeling	`GO:0000812` GO:0000812 defines the Swr1 complex as involved in chromatin remodeling and required for H2AZ incorporation into chromatin.

Discussions

CURATION_TODO (OPEN): Resolve exact source-neutral family groundings for the SWR-C constituents. Wu et al. 2009 describe the budding-yeast SWR1 enzyme as containing fourteen protein subunits. Exact cross-eukaryotic InterPro, Pfam, NCBIfam or UniProt family boundaries for these SWR-C subunit classes need narrower curation before these component labels can be grounded.

Evidence

GO:0000812 Gene Ontology cellular-component term for the Swr1 complex and its exact SWR-C synonym.
GO:0097346 Gene Ontology cellular-component parent term for INO80-type complexes.
GO:0000228 Gene Ontology cellular-component term for the nuclear chromosome.
GO:0140849 Gene Ontology molecular-function term for ATP-dependent H2AZ histone chaperone activity.
GO:0006338 Gene Ontology biological-process term for chromatin remodeling.
PMID:14645854 PubMed identifier for Mizuguchi et al. 2004, the Science paper cited by GO:0000812.
DOI:10.1126/science.1090701 DOI for Mizuguchi et al. 2004, 'ATP-driven exchange of histone H2AZ variant catalyzed by SWR1 chromatin remodeling complex', verified through NCBI E-utilities.
PMID:14690608 PubMed identifier for Krogan et al. 2003, the Molecular Cell SWR-C paper cited by GO:0000812.
DOI:10.1016/s1097-2765(03)00497-0 DOI for Krogan et al. 2003, 'A Snf2 family ATPase complex required for recruitment of the histone H2A variant Htz1', verified through NCBI E-utilities.
PMID:19355820 PubMed identifier for Clapier and Cairns 2009, the Annual Review of Biochemistry chromatin-remodeling review cited by GO:0000812 and GO:0097346.
DOI:10.1146/annurev.biochem.77.062706.153223 DOI for Clapier and Cairns 2009, 'The biology of chromatin remodeling complexes', verified through NCBI E-utilities.
PMID:19088068 PubMed identifier for Wu et al. 2009, the JBC paper that describes the fourteen-subunit budding-yeast SWR1 enzyme.
DOI:10.1074/jbc.M808830200 DOI for Wu et al. 2009, 'N Terminus of Swr1 Binds to Histone H2AZ and Provides a Platform for Subunit Assembly in the Chromatin Remodeling Complex', verified through NCBI E-utilities.

Curation history

2026-09-26T04:53:53Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-09-26T04:55:51Z codex · EXPANDED_RECORD — Added SWR-C exact synonymy, INO80-type parentage, nuclear-chromosome parthood, fourteen SWR-C constituent rows, budding-yeast scope, H2AZ-exchange and chromatin-remodeling functions, GO/PubMed/DOI evidence, a nonmechanistic function graph, and a SWR-C subunit-grounding TODO.
2026-09-26T05:04:25Z codex · FIXED_REVIEW_ISSUE — Resolved issue #1617 by replacing GO's stale 13-subunit Swr1 definition with a DOI-supported H2AZ-exchange definition and by rewording SWR-C component grounding notes so they no longer over-attribute all fourteen subunit labels to GO:0000812.

Source: data/structures/other/swr1_complex.yaml