t-UTP complex

GO:0034455 · Other · Multiprotein complex · Proposed

A protein complex that forms a subcomplex of the 90S preribosome and is required for the subsequent assembly of the rest of the preribosome. In S. cerevisiae, it is composed of Utp5p, Utp4p, Nan1p, Utp8p, Utp9p, Utp10 and Utp15p. [GO:0034455]

Synonyms: Nan1p-containing subcomplex of 90S preribosome

Part of: nucleolus (GO:0005730); 90S preribosome (GO:0030686)

UniProt location names: UniProt Consortium, CC BY 4.0. Reference label and route sources.

Components

Component	Type	Part of / acts on	Grounding	Genes	Essential	Role
Utp5 t-UTP subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	UTP5	UNKNOWN	Protein constituent of the budding-yeast t-UTP complex / Nan1p-containing 90S-preribosome subcomplex. `GO:0034455` GO:0034455 defines the t-UTP complex as containing Utp5p.
Utp4 t-UTP subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	UTP4	UNKNOWN	Protein constituent of the budding-yeast t-UTP complex / Nan1p-containing 90S-preribosome subcomplex. `GO:0034455` GO:0034455 defines the t-UTP complex as containing Utp4p.
Nan1 t-UTP subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	NAN1	UNKNOWN	Protein constituent of the budding-yeast t-UTP complex / Nan1p-containing 90S-preribosome subcomplex. `GO:0034455` GO:0034455 defines the t-UTP complex as containing Nan1p.
Utp8 t-UTP subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	UTP8	UNKNOWN	Protein constituent of the budding-yeast t-UTP complex / Nan1p-containing 90S-preribosome subcomplex. `GO:0034455` GO:0034455 defines the t-UTP complex as containing Utp8p.
Utp9 t-UTP subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	UTP9	UNKNOWN	Protein constituent of the budding-yeast t-UTP complex / Nan1p-containing 90S-preribosome subcomplex. `GO:0034455` GO:0034455 defines the t-UTP complex as containing Utp9p.
Utp10 t-UTP subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	UTP10	UNKNOWN	Protein constituent of the budding-yeast t-UTP complex / Nan1p-containing 90S-preribosome subcomplex. `GO:0034455` GO:0034455 defines the t-UTP complex as containing Utp10.
Utp15 t-UTP subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	UTP15	UNKNOWN	Protein constituent of the budding-yeast t-UTP complex / Nan1p-containing 90S-preribosome subcomplex. `GO:0034455` GO:0034455 defines the t-UTP complex as containing Utp15p.

Taxonomic distribution

NCBITaxon:4932 Saccharomyces cerevisiae — COMMON: Budding yeast is the organism in which the t-UTP complex is GO-defined as a Nan1p-containing subcomplex of the 90S preribosome. [GO:0034455]

Canonical examples

NCBITaxon:4932 Saccharomyces cerevisiae — Perez-Fernandez et al. 2007 characterized t-UTP as an early 90S-preribosome assembly subunit in budding yeast. [DOI:10.1128/MCB.00380-07]

Functions

90S preribosome assembly GO:0034463 — The t-UTP complex forms a subcomplex of the 90S preribosome and acts as an essential early assembly subunit for later recruitment of other 90S-preribosome modules.
- GO:0034455 GO:0034455 defines t-UTP as a subcomplex required for subsequent assembly of the rest of the 90S preribosome.
- GO:0034463 GO:0034463 is the Gene Ontology biological-process term for 90S preribosome assembly.
- DOI:10.1128/MCB.00380-07 Perez-Fernandez et al. 2007 reported that t-UTP assembly is an essential step for engagement of additional 90S subunits on the 35S pre-rRNA.

Mechanism graphs

t-UTP acts as an early 90S preribosome assembly module (ASSEMBLY)

In Saccharomyces cerevisiae, the seven-protein t-UTP complex forms a subcomplex of the 90S preribosome and acts early in the hierarchical assembly pathway.

Subject	Predicate	Object	Evidence
Utp5 t-UTP subunit	contributes to	t-UTP complex	`GO:0034455` GO:0034455 defines Utp5p as a component of the t-UTP complex.
Utp4 t-UTP subunit	contributes to	t-UTP complex	`GO:0034455` GO:0034455 defines Utp4p as a component of the t-UTP complex.
Nan1 t-UTP subunit	contributes to	t-UTP complex	`GO:0034455` GO:0034455 defines Nan1p as a component of the t-UTP complex.
Utp8 t-UTP subunit	contributes to	t-UTP complex	`GO:0034455` GO:0034455 defines Utp8p as a component of the t-UTP complex.
Utp9 t-UTP subunit	contributes to	t-UTP complex	`GO:0034455` GO:0034455 defines Utp9p as a component of the t-UTP complex.
Utp10 t-UTP subunit	contributes to	t-UTP complex	`GO:0034455` GO:0034455 defines Utp10 as a component of the t-UTP complex.
Utp15 t-UTP subunit	contributes to	t-UTP complex	`GO:0034455` GO:0034455 defines Utp15p as a component of the t-UTP complex.
t-UTP complex	part of	90S preribosome	`GO:0034455` GO:0034455 defines t-UTP as a subcomplex of the 90S preribosome.
t-UTP complex	binds	35S pre-rRNA	`DOI:10.1128/MCB.00380-07` Perez-Fernandez et al. 2007 reported that discrete protein subcomplexes of the 90S preribosome bind in defined steps to the 35S pre-rRNA and that t-UTP assembly is required for additional assembly routes.
t-UTP complex	supports	90S preribosome assembly	`GO:0034455` GO:0034455 defines the t-UTP complex as required for subsequent assembly of the rest of the 90S preribosome. `GO:0034463` GO:0034463 is the process term for 90S preribosome assembly. `DOI:10.1128/MCB.00380-07` Perez-Fernandez et al. 2007 found that t-UTP assembly is essential for engagement of at least five additional 90S-preribosome subunits.

Discussions

CURATION_TODO (OPEN): Resolve exact source-neutral family groundings for the Utp5, Utp4, Nan1, Utp8, Utp9, Utp10 and Utp15 constituents of the t-UTP complex. GO:0034455 uses Saccharomyces gene-product names while noting that analogous complexes in other eukaryotes can use the term. Exact cross-eukaryotic InterPro, Pfam, NCBIfam or UniProt family boundaries for the seven t-UTP proteins need narrower follow-up curation before these component labels can be grounded.

Evidence

GO:0034455 Gene Ontology cellular-component term for the t-UTP complex and its exact Nan1p-containing-subcomplex synonym.
GO:0140513 Gene Ontology cellular-component parent term for nuclear protein-containing complexes.
GO:0005730 Gene Ontology cellular-component term for the nucleolus.
GO:0030686 Gene Ontology cellular-component term for the 90S preribosome.
GO:0034463 Gene Ontology biological-process term for 90S preribosome assembly.
PMID:17515605 PubMed identifier for Perez-Fernandez et al. 2007, the Molecular and Cellular Biology paper cited by GO:0034455.
DOI:10.1128/MCB.00380-07 DOI for Perez-Fernandez et al. 2007, 'The 90S preribosome is a multimodular structure that is assembled through a hierarchical mechanism', verified through NCBI E-utilities.

Curation history

2026-09-25T21:59:40Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-09-25T22:00:40Z codex · EXPANDED_RECORD — Added Nan1p-containing-subcomplex synonymy, nuclear protein-containing complex parentage, nucleolar and 90S preribosome parthood, seven reviewed-label-only t-UTP constituent rows, budding-yeast scope, a 90S-preribosome-assembly function, GO/PubMed/DOI evidence, a nonmechanistic assembly graph, and a t-UTP subunit-grounding TODO.

Source: data/structures/other/t_utp_complex.yaml