TRAPPII protein complex

GO:1990071 · Other · Multiprotein complex · Proposed

A complex that mediates intra-Golgi traffic, Golgi exit, endosome-to-Golgi traffic, and the trafficking of autophagy proteins from Golgi to the phagophore assembly site. Binds to a component of the COPI coat. In yeast it includes the following subunits: Bet3 (as homodimer), Bet5, Tca17, Trs20, Trs23, Trs31, Trs33, Trs65, Trs120, Trs130. The whole complex is thought to dimerize with itself. [GO:1990071]

Synonyms: TRAPP II; TRAPP II complex

UniProt location names: UniProt Consortium, CC BY 4.0. Reference label and route sources.

Components

Component	Type	Part of / acts on	Grounding	Genes	Essential	Role
Bet3 TRAPPII subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	BET3	UNKNOWN	Shared TRAPP core constituent present as the homodimeric Bet3 subunit class in yeast TRAPPII. `GO:1990071` GO:1990071 names Bet3 among the yeast TRAPPII protein-complex subunits. `DOI:10.1078/S0171-9335(04)70009-6` Sacher et al. 2000 named Bet3, Bet5, Trs20, Trs23, Trs31 and Trs33 among yeast TRAPP subunits later placed in the shared TRAPP core. `DOI:10.1111/j.1600-0854.2011.01181.x` Choi et al. 2011 described TRAPPII as containing the shared TRAPP core plus Trs65, Trs120, Trs130 and Tca17 as TRAPPII-specific subunits.
Bet5 TRAPPII subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	BET5	UNKNOWN	Shared TRAPP core constituent of the yeast TRAPPII vesicle-tethering complex. `GO:1990071` GO:1990071 names Bet5 among the yeast TRAPPII protein-complex subunits. `DOI:10.1078/S0171-9335(04)70009-6` Sacher et al. 2000 named Bet3, Bet5, Trs20, Trs23, Trs31 and Trs33 among yeast TRAPP subunits later placed in the shared TRAPP core. `DOI:10.1111/j.1600-0854.2011.01181.x` Choi et al. 2011 described TRAPPII as containing the shared TRAPP core plus Trs65, Trs120, Trs130 and Tca17 as TRAPPII-specific subunits.
Tca17 TRAPPII subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	TCA17	UNKNOWN	TRAPPII-specific constituent that promotes stable association of yeast TRAPPII-specific subunits with the shared core complex. `GO:1990071` GO:1990071 names Tca17 among the yeast TRAPPII protein-complex subunits. `DOI:10.1111/j.1600-0854.2009.00895.x` Montpetit and Conibear 2009 identified Tca17 as a TRAPP-associated protein. `DOI:10.1111/j.1600-0854.2011.01181.x` Choi et al. 2011 showed that Tca17 is a fourth yeast TRAPPII-specific component alongside Trs65, Trs120 and Trs130.
Trs20 TRAPPII subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	TRS20	UNKNOWN	Shared TRAPP core constituent of the yeast TRAPPII vesicle-tethering complex. `GO:1990071` GO:1990071 names Trs20 among the yeast TRAPPII protein-complex subunits. `DOI:10.1078/S0171-9335(04)70009-6` Sacher et al. 2000 named Bet3, Bet5, Trs20, Trs23, Trs31 and Trs33 among yeast TRAPP subunits later placed in the shared TRAPP core. `DOI:10.1111/j.1600-0854.2011.01181.x` Choi et al. 2011 described TRAPPII as containing the shared TRAPP core plus Trs65, Trs120, Trs130 and Tca17 as TRAPPII-specific subunits.
Trs23 TRAPPII subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	TRS23	UNKNOWN	Shared TRAPP core constituent of the yeast TRAPPII vesicle-tethering complex. `GO:1990071` GO:1990071 names Trs23 among the yeast TRAPPII protein-complex subunits. `DOI:10.1078/S0171-9335(04)70009-6` Sacher et al. 2000 named Bet3, Bet5, Trs20, Trs23, Trs31 and Trs33 among yeast TRAPP subunits later placed in the shared TRAPP core. `DOI:10.1111/j.1600-0854.2011.01181.x` Choi et al. 2011 described TRAPPII as containing the shared TRAPP core plus Trs65, Trs120, Trs130 and Tca17 as TRAPPII-specific subunits.
Trs31 TRAPPII subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	TRS31	UNKNOWN	Shared TRAPP core constituent of the yeast TRAPPII vesicle-tethering complex. `GO:1990071` GO:1990071 names Trs31 among the yeast TRAPPII protein-complex subunits. `DOI:10.1078/S0171-9335(04)70009-6` Sacher et al. 2000 named Bet3, Bet5, Trs20, Trs23, Trs31 and Trs33 among yeast TRAPP subunits later placed in the shared TRAPP core. `DOI:10.1111/j.1600-0854.2011.01181.x` Choi et al. 2011 described TRAPPII as containing the shared TRAPP core plus Trs65, Trs120, Trs130 and Tca17 as TRAPPII-specific subunits.
Trs33 TRAPPII subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	TRS33	UNKNOWN	Shared TRAPP core constituent of the yeast TRAPPII vesicle-tethering complex. `GO:1990071` GO:1990071 names Trs33 among the yeast TRAPPII protein-complex subunits. `DOI:10.1078/S0171-9335(04)70009-6` Sacher et al. 2000 named Bet3, Bet5, Trs20, Trs23, Trs31 and Trs33 among yeast TRAPP subunits later placed in the shared TRAPP core. `DOI:10.1111/j.1600-0854.2011.01181.x` Choi et al. 2011 described TRAPPII as containing the shared TRAPP core plus Trs65, Trs120, Trs130 and Tca17 as TRAPPII-specific subunits.
Trs65 TRAPPII subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	TRS65	UNKNOWN	TRAPPII-specific constituent that stabilizes yeast TRAPPII in an oligomeric form. `GO:1990071` GO:1990071 names Trs65 among the yeast TRAPPII protein-complex subunits. `DOI:10.1078/S0171-9335(04)70009-6` Sacher et al. 2000 identified Trs65 among the additional yeast TRAPP subunits. `DOI:10.1111/j.1600-0854.2011.01181.x` Choi et al. 2011 showed that Tca17 is a fourth yeast TRAPPII-specific component alongside Trs65, Trs120 and Trs130.
Trs120 TRAPPII subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	TRS120	UNKNOWN	TRAPPII-specific constituent of the larger yeast TRAPPII assembly. `GO:1990071` GO:1990071 names Trs120 among the yeast TRAPPII protein-complex subunits. `DOI:10.1078/S0171-9335(04)70009-6` Sacher et al. 2000 identified Trs120 among the additional yeast TRAPP subunits. `DOI:10.1111/j.1600-0854.2011.01181.x` Choi et al. 2011 showed that Tca17 is a fourth yeast TRAPPII-specific component alongside Trs65, Trs120 and Trs130.
Trs130 TRAPPII subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	TRS130	UNKNOWN	TRAPPII-specific constituent that binds Trs65 and Tca17 through distinct domains in yeast TRAPPII. `GO:1990071` GO:1990071 names Trs130 among the yeast TRAPPII protein-complex subunits. `DOI:10.1078/S0171-9335(04)70009-6` Sacher et al. 2000 identified Trs130 among the additional yeast TRAPP subunits. `DOI:10.1111/j.1600-0854.2011.01181.x` Choi et al. 2011 showed that Tca17 is a fourth yeast TRAPPII-specific component alongside Trs65, Trs120 and Trs130.

Taxonomic distribution

NCBITaxon:4932 Saccharomyces cerevisiae — COMMON: Budding yeast has a TRAPPII complex with shared TRAPP core subunits and the Tca17/Trs65/Trs120/Trs130 TRAPPII-specific subunits. [DOI:10.1111/j.1600-0854.2011.01181.x]

Canonical examples

NCBITaxon:4932 Saccharomyces cerevisiae — Budding-yeast model used to define Tca17 as the fourth TRAPPII-specific subunit. [DOI:10.1111/j.1600-0854.2011.01181.x]

Functions

intra-Golgi vesicle-mediated transport GO:0006891 — TRAPPII acts as a multisubunit tethering complex for vesicle transport at Golgi membranes.
- GO:0006891 GO:0006891 denotes vesicle-mediated directed movement of substances within the Golgi.
- DOI:10.1111/j.1600-0854.2011.01181.x Choi et al. 2011 described yeast TRAPPII as required for distinct tethering events at Golgi membranes.

Mechanism graphs

TRAPPII supports yeast Golgi tethering (FUNCTION)

In Saccharomyces cerevisiae, the Bet3/Bet5/Trs20/Trs23/Trs31/Trs33 TRAPP core associates with Tca17, Trs65, Trs120 and Trs130 to form TRAPPII for tethering events at Golgi membranes.

Subject	Predicate	Object	Evidence
Bet3 TRAPPII subunit	is part of	TRAPPII protein complex	`GO:1990071` GO:1990071 names Bet3 among the yeast TRAPPII subunits. `DOI:10.1111/j.1600-0854.2011.01181.x` Choi et al. 2011 described yeast TRAPPII as a TRAPP core plus Trs65, Trs120, Trs130 and the fourth TRAPPII-specific component Tca17.
Bet5 TRAPPII subunit	is part of	TRAPPII protein complex	`GO:1990071` GO:1990071 names Bet5 among the yeast TRAPPII subunits. `DOI:10.1111/j.1600-0854.2011.01181.x` Choi et al. 2011 described yeast TRAPPII as a TRAPP core plus Trs65, Trs120, Trs130 and the fourth TRAPPII-specific component Tca17.
Tca17 TRAPPII subunit	is part of	TRAPPII protein complex	`GO:1990071` GO:1990071 names Tca17 among the yeast TRAPPII subunits. `DOI:10.1111/j.1600-0854.2011.01181.x` Choi et al. 2011 described yeast TRAPPII as a TRAPP core plus Trs65, Trs120, Trs130 and the fourth TRAPPII-specific component Tca17.
Trs20 TRAPPII subunit	is part of	TRAPPII protein complex	`GO:1990071` GO:1990071 names Trs20 among the yeast TRAPPII subunits. `DOI:10.1111/j.1600-0854.2011.01181.x` Choi et al. 2011 described yeast TRAPPII as a TRAPP core plus Trs65, Trs120, Trs130 and the fourth TRAPPII-specific component Tca17.
Trs23 TRAPPII subunit	is part of	TRAPPII protein complex	`GO:1990071` GO:1990071 names Trs23 among the yeast TRAPPII subunits. `DOI:10.1111/j.1600-0854.2011.01181.x` Choi et al. 2011 described yeast TRAPPII as a TRAPP core plus Trs65, Trs120, Trs130 and the fourth TRAPPII-specific component Tca17.
Trs31 TRAPPII subunit	is part of	TRAPPII protein complex	`GO:1990071` GO:1990071 names Trs31 among the yeast TRAPPII subunits. `DOI:10.1111/j.1600-0854.2011.01181.x` Choi et al. 2011 described yeast TRAPPII as a TRAPP core plus Trs65, Trs120, Trs130 and the fourth TRAPPII-specific component Tca17.
Trs33 TRAPPII subunit	is part of	TRAPPII protein complex	`GO:1990071` GO:1990071 names Trs33 among the yeast TRAPPII subunits. `DOI:10.1111/j.1600-0854.2011.01181.x` Choi et al. 2011 described yeast TRAPPII as a TRAPP core plus Trs65, Trs120, Trs130 and the fourth TRAPPII-specific component Tca17.
Trs65 TRAPPII subunit	is part of	TRAPPII protein complex	`GO:1990071` GO:1990071 names Trs65 among the yeast TRAPPII subunits. `DOI:10.1111/j.1600-0854.2011.01181.x` Choi et al. 2011 described yeast TRAPPII as a TRAPP core plus Trs65, Trs120, Trs130 and the fourth TRAPPII-specific component Tca17.
Trs120 TRAPPII subunit	is part of	TRAPPII protein complex	`GO:1990071` GO:1990071 names Trs120 among the yeast TRAPPII subunits. `DOI:10.1111/j.1600-0854.2011.01181.x` Choi et al. 2011 described yeast TRAPPII as a TRAPP core plus Trs65, Trs120, Trs130 and the fourth TRAPPII-specific component Tca17.
Trs130 TRAPPII subunit	is part of	TRAPPII protein complex	`GO:1990071` GO:1990071 names Trs130 among the yeast TRAPPII subunits. `DOI:10.1111/j.1600-0854.2011.01181.x` Choi et al. 2011 described yeast TRAPPII as a TRAPP core plus Trs65, Trs120, Trs130 and the fourth TRAPPII-specific component Tca17.
TRAPPII protein complex	participates in	intra-Golgi vesicle-mediated transport	`DOI:10.1111/j.1600-0854.2011.01181.x` Choi et al. 2011 described TRAPPII as required for distinct tethering events at Golgi membranes.

Discussions

CURATION_TODO (OPEN): Resolve exact source-neutral family groundings for the ten yeast TRAPPII subunits. This first TRAPPII record names the yeast Bet3, Bet5, Tca17, Trs20, Trs23, Trs31, Trs33, Trs65, Trs120 and Trs130 constituent subunits but leaves InterPro, Pfam, or Complex Portal grounding unset until exact orthology and paralogy boundaries are reviewed per subunit.
CURATION_TODO (RESOLVED): Do not model Trs85 as a constituent yeast TRAPPII subunit. Trs85 is represented in GO:1990072 as a defining yeast TRAPPIII subunit. Choi et al. 2011 directly tested yeast TRAPPII composition and found Trs85 was not associated with the yeast TRAPPII complex.

Evidence

GO:1990071 Gene Ontology cellular-component term for the TRAPPII protein complex.
GO:0030008 Gene Ontology cellular-component parent term for TRAPP complexes.
GO:0006891 Gene Ontology biological-process term for intra-Golgi vesicle-mediated transport.
DOI:10.1078/S0171-9335(04)70009-6 Sacher et al. 2000, Identification and characterization of five new subunits of TRAPP, European Journal of Cell Biology.
DOI:10.1016/s1097-2765(01)00190-3 Sacher et al. 2001, TRAPP I implicated in the specificity of tethering in ER-to-Golgi transport, Molecular Cell.
DOI:10.1111/j.1600-0854.2009.00895.x Montpetit and Conibear 2009, Identification of the novel TRAPP associated protein Tca17, Traffic.
DOI:10.1111/j.1600-0854.2011.01181.x Choi et al. 2011, Organization and assembly of the TRAPPII complex, Traffic.

Curation history

2026-09-17T07:44:00Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-09-17T07:45:06Z codex · EXPANDED_RECORD — Added TRAPPII synonymy, TRAPP parentage, reviewed-label-only yeast components for the shared core and Tca17/Trs65/Trs120/Trs130 TRAPPII-specific subunits, Saccharomyces cerevisiae scope, an intra-Golgi transport function, GO/DOI evidence, a nonmechanistic yeast TRAPPII tethering graph, a subunit-grounding TODO, and a resolved Trs85 boundary decision.
2026-09-17T07:45:58Z codex · REFINED_RECORD — Detached repeated evidence objects before YAML emission, narrowed the Trs120 role statement, and made TRAPPII graph-edge evidence notes describe the Choi et al. 2011 subunit boundary more directly.
2026-09-17T07:58:10Z codex · ADDRESSED_PR_REVIEW — Resolved PR #1127 issue #1128 by replacing the six shared-core TRAPPII component rows' Choi et al. 2011 wording with neutral component-membership evidence.

Source: data/structures/other/trappii_protein_complex.yaml