supraspliceosomal complex

GO:0044530 · Ribonucleoprotein · Ribonucleoprotein complex · Proposed

Multicomponent complex of RNA and proteins that is composed of four active spliceosomes, termed native spliceosomes, connected to each other by the pre-mRNA. The supraspliceosome is the nuclear machine where the pre-mRNA processing takes place, like the 5'-end capping, 3'-end cleavage, splicing and editing. [GO:0044530]

Synonyms: supraspliceosome complex

UniProt location names: UniProt Consortium, CC BY 4.0. Reference label and route sources.

Components

Component	Type	Part of / acts on	Grounding	Genes	Stoichiometry	Essential	Role
spliceosomal complex	Protein complex	part of	`GO:0005681`		4		Active spliceosomal-complex substructure represented four times in the supraspliceosomal complex. `GO:0044530` GO:0044530 defines the supraspliceosomal complex as composed of four active spliceosomes, termed native spliceosomes. `GO:0005681` GO:0005681 is the Gene Ontology cellular-component term for spliceosomal complex.
pre-mRNA	Rna	part of	Reviewed label only (reviewed name; no accession asserted)				Pre-mRNA RNA constituent that connects the four active spliceosomal complexes in the supraspliceosomal complex. `GO:0044530` GO:0044530 defines the supraspliceosomal complex as four active spliceosomes connected to each other by the pre-mRNA.

Mechanism graphs

Four spliceosomal complexes and pre-mRNA form the supraspliceosomal complex (ASSEMBLY)

The supraspliceosomal complex contains four active spliceosomal complexes connected by pre-mRNA.

Subject	Predicate	Object	Evidence
spliceosomal complex	contributes constituents to	supraspliceosomal complex	`GO:0044530` GO:0044530 defines the supraspliceosomal complex as composed of four active spliceosomes. `GO:0005681` GO:0005681 is the parent spliceosomal-complex term.
pre-mRNA	connects subcomplexes in	supraspliceosomal complex	`GO:0044530` GO:0044530 defines the active spliceosomes in a supraspliceosomal complex as connected to each other by the pre-mRNA.

Discussions

CURATION_TODO (OPEN): Resolve exact source-neutral component boundaries for the native spliceosome and pre-mRNA constituents of the supraspliceosomal complex. The first GO:0044530 record captures only the GO-defined four active spliceosomal complexes and connecting pre-mRNA. Exact native-spliceosome state boundaries, substrate-RNA grounding and additional protein-family composition should be resolved before expanding the component list.

Evidence

GO:0044530 Gene Ontology cellular-component term for supraspliceosomal complex and its exact synonym.
GO:0005681 Gene Ontology cellular-component parent term for spliceosomal complex.

Curation history

2026-09-25T11:32:57Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-09-25T11:33:39Z codex · EXPANDED_RECORD — Added the GO exact synonym, spliceosomal-complex parentage, GO-grounded four-spliceosomal-complex and reviewed-label-only pre-mRNA components, a conservative constituent graph and a TODO for exact native-spliceosome and pre-mRNA boundaries.

Source: data/structures/ribonucleoprotein/supraspliceosomal_complex.yaml