DUFMech

All families / PF01935

PF01935: DUF87

Helicase HerA, central domain

Curation status
SEEDED
Seed status
KNOWN HISTORICAL DUF
Characterization
UNSCORED

Grounding

PF01935: Helicase HerA, central domain
IPR002789: integrated entry for Helicase HerA, central domain

Source description

This entry represents the central domain found in archaeal proteins such as DNA double-strand break repair helicase HerA ([ec:3.6.4.12]). HerA is a helicase which is able to utilise either 3' or 5' single-stranded DNA extensions for loading and subsequent DNA duplex unwinding [InterPro reference PUB00076694]. It forms a complex with NurA nuclease, this complex has the 5'-3' DNA end resection activity and is essential for cell viability in the crenarchaeon Sulfolobus islandicus [InterPro reference PUB00076695]. This domain includes the the central RecA-like catalytic core and a flanking four-helix bundle [InterPro reference PUB00078094]. The function of this prokaryotic domain is unknown. It contains several conserved aspartates and histidines that could be metal ligands.

Evidence and references

Source descriptions and links are provenance, not independent functional validation.

Evidence counts: not scored.

Curated functional assertions

No curated functional assertions supplied.

Protein sequence examples

7 verified sequence examples. FASTA

UniProtProtein / organismSequenceProvenance
F2Z5Z6DNA double-strand break repair helicase HerA
Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
495 aa; version 1
UniProt 2026_03
UNIPROT FETCH
3 sibling references
Q58824Probable DNA double-strand break repair helicase HerA
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)
503 aa; version 1
UniProt 2026_03
UNIPROT FETCH
2 sibling references
Q58960Probable helicase MJ1565
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)
513 aa; version 1
UniProt 2026_03
UNIPROT FETCH
3 sibling references
Q60270Probable helicase MJECL08
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)
520 aa; version 1
UniProt 2026_03
UNIPROT FETCH
3 sibling references
Q8U1P0DNA double-strand break repair helicase HerA
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
551 aa; version 1
UniProt 2026_03
UNIPROT FETCH
1 sibling references
Q96YR7DNA double-strand break repair helicase HerA
Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
495 aa; version 1
UniProt 2026_03
UNIPROT FETCH
3 sibling references
Q97WG8DNA double-strand break repair helicase HerA
Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
500 aa; version 1
UniProt 2026_03
UNIPROT FETCH
2 sibling references

Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.

Sequences and metadata: UniProt Consortium, CC BY 4.0.

Domain matches

No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.

Snapshot counters

proteins
11,479
matches
11,481
proteomes
6,966
taxa
11,524
structures
38
alphafold models
7,658
domain architectures
87

Classification basis

short name matches duf

No scoring reasons supplied.

Related Mech records

FamilyMechRecordProteinLink basis
DUF87 (PF01935)ProteinTraitsMechHelicase HerA, barrel domainQ58824
Probable DNA double-strand break repair helicase HerA
canonical example family classification
DUF87 (PF01935)ProteinTraitsMechHelicase HerA, barrel domainQ58960
Probable helicase MJ1565
canonical example family classification
DUF87 (PF01935)ProteinTraitsMechHelicase HerA, barrel domainQ60270
Probable helicase MJECL08
canonical example family classification
DUF87 (PF01935)ProteinTraitsMechHelicase HerA, central domainQ58824
Probable DNA double-strand break repair helicase HerA
canonical example family classification
DUF87 (PF01935)ProteinTraitsMechHelicase HerA, central domainQ58960
Probable helicase MJ1565
canonical example family classification
DUF87 (PF01935)ProteinTraitsMechHelicase HerA, central domainQ60270
Probable helicase MJECL08
canonical example family classification
DUF87 (PF01935)ProteinTraitsMechHelicase HerA, central domain
trait identifier
DUF87 (PF01935)ProteinTraitsMechHelicase HerA-like C-terminalQ58960
Probable helicase MJ1565
canonical example family classification
DUF87 (PF01935)ProteinTraitsMechHelicase HerA-like C-terminalQ60270
Probable helicase MJECL08
canonical example family classification
DUF87 (PF01935)ProteinTraitsMechHelicase HerA, central domainF2Z5Z6
DNA double-strand break repair helicase HerA
canonical example family classification
DUF87 (PF01935)ProteinTraitsMechHelicase HerA, central domainQ96YR7
DNA double-strand break repair helicase HerA
canonical example family classification
DUF87 (PF01935)ProteinTraitsMechHelicase HerA, central domainQ97WG8
DNA double-strand break repair helicase HerA
canonical example family classification
DUF87 (PF01935)ProteinTraitsMechHelicase HerA, central domain
trait identifier
DUF87 (PF01935)ProteinTraitsMechHAS barrel domainF2Z5Z6
DNA double-strand break repair helicase HerA
canonical example family classification
DUF87 (PF01935)ProteinTraitsMechHAS barrel domainQ96YR7
DNA double-strand break repair helicase HerA
canonical example family classification
DUF87 (PF01935)ProteinTraitsMechHAS barrel domainQ97WG8
DNA double-strand break repair helicase HerA
canonical example family classification
DUF87 (PF01935)ProteinTraitsMechHelicase HerA-like C-terminalF2Z5Z6
DNA double-strand break repair helicase HerA
canonical example family classification
DUF87 (PF01935)ProteinTraitsMechHelicase HerA-like C-terminalQ8U1P0
DNA double-strand break repair helicase HerA
canonical example family classification
DUF87 (PF01935)ProteinTraitsMechHelicase HerA-like C-terminalQ96YR7
DNA double-strand break repair helicase HerA
canonical example family classification

Curation history and reviews

No retained curation events supplied.

No retained review supplied.

Record source

data/families/PF01935.yaml
Family YAML in this build

Download this family (JSON)

Status and evidence

Seed status
A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
Characterization
A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
Evidence counts
Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
Curation status
Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
Missing counts
Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.