All families / PF01935
PF01935: DUF87
Helicase HerA, central domain
- Curation status
- SEEDED
- Seed status
- KNOWN HISTORICAL DUF
- Characterization
- UNSCORED
Grounding
PF01935: Helicase HerA, central domain
IPR002789: integrated entry for Helicase HerA, central domain
Source description
This entry represents the central domain found in archaeal proteins such as DNA double-strand break repair helicase HerA ([ec:3.6.4.12]). HerA is a helicase which is able to utilise either 3' or 5' single-stranded DNA extensions for loading and subsequent DNA duplex unwinding [InterPro reference PUB00076694]. It forms a complex with NurA nuclease, this complex has the 5'-3' DNA end resection activity and is essential for cell viability in the crenarchaeon Sulfolobus islandicus [InterPro reference PUB00076695]. This domain includes the the central RecA-like catalytic core and a flanking four-helix bundle [InterPro reference PUB00078094]. The function of this prokaryotic domain is unknown. It contains several conserved aspartates and histidines that could be metal ligands.
Evidence and references
- InterPro entry and its literature references. PUB identifiers are internal InterPro references, not PubMed identifiers. Unresolved citations link to the originating entry.
- Frozen description source: InterPro/Pfam API
Source descriptions and links are provenance, not independent functional validation.
Evidence counts: not scored.
Curated functional assertions
No curated functional assertions supplied.
Protein sequence examples
7 verified sequence examples. FASTA
| UniProt | Protein / organism | Sequence | Provenance |
|---|---|---|---|
| F2Z5Z6 | DNA double-strand break repair helicase HerA Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) | 495 aa; version 1 UniProt 2026_03 | UNIPROT FETCH |
| Q58824 | Probable DNA double-strand break repair helicase HerA Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) | 503 aa; version 1 UniProt 2026_03 | UNIPROT FETCH2 sibling references |
| Q58960 | Probable helicase MJ1565 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) | 513 aa; version 1 UniProt 2026_03 | UNIPROT FETCH |
| Q60270 | Probable helicase MJECL08 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) | 520 aa; version 1 UniProt 2026_03 | UNIPROT FETCH |
| Q8U1P0 | DNA double-strand break repair helicase HerA Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) | 551 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| Q96YR7 | DNA double-strand break repair helicase HerA Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) | 495 aa; version 1 UniProt 2026_03 | UNIPROT FETCH |
| Q97WG8 | DNA double-strand break repair helicase HerA Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) | 500 aa; version 1 UniProt 2026_03 | UNIPROT FETCH2 sibling references |
Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.
Sequences and metadata: UniProt Consortium, CC BY 4.0.
Domain matches
No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.
Snapshot counters
- proteins
- 11,479
- matches
- 11,481
- proteomes
- 6,966
- taxa
- 11,524
- structures
- 38
- alphafold models
- 7,658
- domain architectures
- 87
Classification basis
short name matches duf
No scoring reasons supplied.
Related Mech records
| Family | Mech | Record | Protein | Link basis |
|---|---|---|---|---|
| DUF87 (PF01935) | ProteinTraitsMech | Helicase HerA, barrel domain | Q58824 Probable DNA double-strand break repair helicase HerA | canonical example family classification |
| DUF87 (PF01935) | ProteinTraitsMech | Helicase HerA, barrel domain | Q58960 Probable helicase MJ1565 | canonical example family classification |
| DUF87 (PF01935) | ProteinTraitsMech | Helicase HerA, barrel domain | Q60270 Probable helicase MJECL08 | canonical example family classification |
| DUF87 (PF01935) | ProteinTraitsMech | Helicase HerA, central domain | Q58824 Probable DNA double-strand break repair helicase HerA | canonical example family classification |
| DUF87 (PF01935) | ProteinTraitsMech | Helicase HerA, central domain | Q58960 Probable helicase MJ1565 | canonical example family classification |
| DUF87 (PF01935) | ProteinTraitsMech | Helicase HerA, central domain | Q60270 Probable helicase MJECL08 | canonical example family classification |
| DUF87 (PF01935) | ProteinTraitsMech | Helicase HerA, central domain | trait identifier | |
| DUF87 (PF01935) | ProteinTraitsMech | Helicase HerA-like C-terminal | Q58960 Probable helicase MJ1565 | canonical example family classification |
| DUF87 (PF01935) | ProteinTraitsMech | Helicase HerA-like C-terminal | Q60270 Probable helicase MJECL08 | canonical example family classification |
| DUF87 (PF01935) | ProteinTraitsMech | Helicase HerA, central domain | F2Z5Z6 DNA double-strand break repair helicase HerA | canonical example family classification |
| DUF87 (PF01935) | ProteinTraitsMech | Helicase HerA, central domain | Q96YR7 DNA double-strand break repair helicase HerA | canonical example family classification |
| DUF87 (PF01935) | ProteinTraitsMech | Helicase HerA, central domain | Q97WG8 DNA double-strand break repair helicase HerA | canonical example family classification |
| DUF87 (PF01935) | ProteinTraitsMech | Helicase HerA, central domain | trait identifier | |
| DUF87 (PF01935) | ProteinTraitsMech | HAS barrel domain | F2Z5Z6 DNA double-strand break repair helicase HerA | canonical example family classification |
| DUF87 (PF01935) | ProteinTraitsMech | HAS barrel domain | Q96YR7 DNA double-strand break repair helicase HerA | canonical example family classification |
| DUF87 (PF01935) | ProteinTraitsMech | HAS barrel domain | Q97WG8 DNA double-strand break repair helicase HerA | canonical example family classification |
| DUF87 (PF01935) | ProteinTraitsMech | Helicase HerA-like C-terminal | F2Z5Z6 DNA double-strand break repair helicase HerA | canonical example family classification |
| DUF87 (PF01935) | ProteinTraitsMech | Helicase HerA-like C-terminal | Q8U1P0 DNA double-strand break repair helicase HerA | canonical example family classification |
| DUF87 (PF01935) | ProteinTraitsMech | Helicase HerA-like C-terminal | Q96YR7 DNA double-strand break repair helicase HerA | canonical example family classification |
Curation history and reviews
No retained curation events supplied.
No retained review supplied.
Record source
Status and evidence
- Seed status
- A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
- Characterization
- A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
- Evidence counts
- Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
- Curation status
- Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
- Missing counts
- Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.