All families / PF01940
PF01940: DUF92
Integral membrane protein DUF92
- Curation status
- SEEDED
- Seed status
- KNOWN HISTORICAL DUF
- Characterization
- UNSCORED
Grounding
PF01940: Integral membrane protein DUF92
IPR002794: integrated entry for Integral membrane protein DUF92
Source description
Members of this family have several predicted transmembrane helices. One member of the family has been characterised as protein PGR (AtPGR). PGR is suggested to be a potential glucose-responsive regulator in carbohydrate metabolism in plants. This entry also includes protein VTE6, which is a Pphytyl-phosphate kinase catalysing the conversion of phytyl-monophosphate to phytyl-diphosphate [InterPro reference PUB00092523].
Evidence and references
- InterPro entry and its literature references. PUB identifiers are internal InterPro references, not PubMed identifiers. Unresolved citations link to the originating entry.
- Frozen description source: InterPro/Pfam API
Source descriptions and links are provenance, not independent functional validation.
Evidence counts: not scored.
Curated functional assertions
No curated functional assertions supplied.
Protein sequence examples
4 verified sequence examples. FASTA
| UniProt | Protein / organism | Sequence | Provenance |
|---|---|---|---|
| Q0WP96 | Protein PGR Arabidopsis thaliana | 288 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| Q58343 | Uncharacterized membrane protein MJ0933 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) | 238 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| Q96HH6 | Transmembrane protein 19 Homo sapiens | 336 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| Q9SYM0 | Protein VTE6, chloroplastic Arabidopsis thaliana | 333 aa; version 1 UniProt 2026_03 | PTM REGISTRY MIRROR |
Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.
Sequences and metadata: UniProt Consortium, CC BY 4.0.
Domain matches
No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.
Snapshot counters
- proteins
- 6,136
- matches
- 6,228
- proteomes
- 4,750
- taxa
- 11,004
- structures
- 0
- alphafold models
- 4,924
- domain architectures
- 97
Classification basis
short name matches duf
No scoring reasons supplied.
Related Mech records
| Family | Mech | Record | Protein | Link basis |
|---|---|---|---|---|
| DUF92 (PF01940) | ProteinTraitsMech | phytol kinase activity | Q9SYM0 Protein VTE6, chloroplastic | canonical example family classification |
| DUF92 (PF01940) | ProteinTraitsMech | phytyl-P kinase activity | Q9SYM0 Protein VTE6, chloroplastic | canonical example family classification |
| DUF92 (PF01940) | ProteinTraitsMech | phytol metabolic process | Q9SYM0 Protein VTE6, chloroplastic | canonical example family classification |
| DUF92 (PF01940) | ProteinTraitsMech | vitamin E biosynthetic process | Q9SYM0 Protein VTE6, chloroplastic | canonical example family classification |
| DUF92 (PF01940) | ProteinTraitsMech | vitamin K biosynthetic process | Q9SYM0 Protein VTE6, chloroplastic | canonical example family classification |
| DUF92 (PF01940) | ProteinTraitsMech | TIGR00297 family protein | Q58343 Uncharacterized membrane protein MJ0933 | canonical example family classification |
| DUF92 (PF01940) | ProteinTraitsMech | Integral membrane protein DUF92 | Q0WP96 Protein PGR | canonical example family classification |
| DUF92 (PF01940) | ProteinTraitsMech | Integral membrane protein DUF92 | Q96HH6 Transmembrane protein 19 | canonical example family classification |
| DUF92 (PF01940) | ProteinTraitsMech | Integral membrane protein DUF92 | Q9SYM0 Protein VTE6, chloroplastic | canonical example family classification |
| DUF92 (PF01940) | ProteinTraitsMech | Integral membrane protein DUF92 | trait identifier |
Curation history and reviews
No retained curation events supplied.
No retained review supplied.
Record source
Status and evidence
- Seed status
- A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
- Characterization
- A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
- Evidence counts
- Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
- Curation status
- Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
- Missing counts
- Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.