All families / PF02698
PF02698: DUF218
DUF218 domain
- Curation status
- SEEDED
- Seed status
- KNOWN HISTORICAL DUF
- Characterization
- UNSCORED
Grounding
PF02698: DUF218 domain
IPR003848: integrated entry for DUF218 domain
Source description
This domain contains several highly conserved charged amino acids, suggesting this may be an enzymatic domain (Bateman A pers. obs). The entry includes SanA P33017 (UniProtKB protein) and Sfix (O33790 (UniProtKB protein)) from Salmonella typhimurium which are involved in Vancomycin resistance [InterPro reference PUB00019464]. These proteins may be involved in murein synthesis [InterPro reference PUB00019465]. This domain is found in Escherichia coli YdcF, which has been shown to bind S-adenosyl-L-methionine (AdoMet), but whose biochemical function has not been identified [InterPro reference PUB00050945].
Evidence and references
- InterPro entry and its literature references. PUB identifiers are internal InterPro references, not PubMed identifiers. Unresolved citations link to the originating entry.
- Frozen description source: InterPro/Pfam API
Source descriptions and links are provenance, not independent functional validation.
Evidence counts: not scored.
Curated functional assertions
No curated functional assertions supplied.
Protein sequence examples
4 verified sequence examples. FASTA
| UniProt | Protein / organism | Sequence | Provenance |
|---|---|---|---|
| P0AB01 | Envelope biogenesis factor ElyC Escherichia coli (strain K12) | 259 aa; version 1 UniProt 2026_03 | PTM REGISTRY MIRROR |
| P0AFY2 | Peptidoglycan biosynthesis regulator SanA Escherichia coli (strain K12) | 239 aa; version 1 UniProt 2026_03 | PTM REGISTRY MIRROR |
| P34209 | Protein YdcF Escherichia coli (strain K12) | 266 aa; version 3 UniProt 2026_03 | UNIPROT FETCH |
| P42598 | Uncharacterized protein YgjQ Escherichia coli (strain K12) | 230 aa; version 1 UniProt 2026_03 | UNIPROT FETCH2 sibling references |
Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.
Sequences and metadata: UniProt Consortium, CC BY 4.0.
Domain matches
No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.
Snapshot counters
- proteins
- 25,685
- matches
- 25,685
- proteomes
- 14,217
- taxa
- 20,830
- structures
- 1
- alphafold models
- 15,881
- domain architectures
- 92
Classification basis
short name matches duf
No scoring reasons supplied.
Related Mech records
| Family | Mech | Record | Protein | Link basis |
|---|---|---|---|---|
| DUF218 (PF02698) | ProteinTraitsMech | Gram-negative-bacterium-type cell wall biogenesis | P0AB01 Envelope biogenesis factor ElyC | canonical example family classification |
| DUF218 (PF02698) | ProteinTraitsMech | envelope biogenesis factor ElyC | P0AB01 Envelope biogenesis factor ElyC | canonical example family classification |
| DUF218 (PF02698) | ProteinTraitsMech | outer membrane permeability protein SanA | P0AFY2 Peptidoglycan biosynthesis regulator SanA | canonical example family classification |
| DUF218 (PF02698) | ProteinTraitsMech | YdcF-like | P0AB01 Envelope biogenesis factor ElyC | canonical example family classification |
| DUF218 (PF02698) | ProteinTraitsMech | YdcF-like | P0AFY2 Peptidoglycan biosynthesis regulator SanA | canonical example family classification |
| DUF218 (PF02698) | ProteinTraitsMech | YdcF-like | P34209 Protein YdcF | canonical example family classification |
| DUF218 (PF02698) | ProteinTraitsMech | YdcF-like | P42598 Uncharacterized protein YgjQ | canonical example family classification |
| DUF218 (PF02698) | ProteinTraitsMech | Domain of unknown function DUF218 | P0AB01 Envelope biogenesis factor ElyC | canonical example family classification |
| DUF218 (PF02698) | ProteinTraitsMech | Domain of unknown function DUF218 | P0AFY2 Peptidoglycan biosynthesis regulator SanA | canonical example family classification |
| DUF218 (PF02698) | ProteinTraitsMech | Domain of unknown function DUF218 | P34209 Protein YdcF | canonical example family classification |
| DUF218 (PF02698) | ProteinTraitsMech | Domain of unknown function DUF218 | P42598 Uncharacterized protein YgjQ | canonical example family classification |
| DUF218 (PF02698) | ProteinTraitsMech | Domain of unknown function DUF218 | trait identifier | |
| DUF218 (PF02698) | ProteinTraitsMech | DUF218 domain | P0AB01 Envelope biogenesis factor ElyC | canonical example family classification |
| DUF218 (PF02698) | ProteinTraitsMech | DUF218 domain | P0AFY2 Peptidoglycan biosynthesis regulator SanA | canonical example family classification |
| DUF218 (PF02698) | ProteinTraitsMech | DUF218 domain | P34209 Protein YdcF | canonical example family classification |
| DUF218 (PF02698) | ProteinTraitsMech | DUF218 domain | trait identifier | |
| DUF218 (PF02698) | ProteinTraitsMech | YdcF like domain | P34209 Protein YdcF | canonical example family classification |
Curation history and reviews
No retained curation events supplied.
No retained review supplied.
Record source
Status and evidence
- Seed status
- A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
- Characterization
- A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
- Evidence counts
- Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
- Curation status
- Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
- Missing counts
- Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.