All families / PF04037
PF04037: DUF382
Domain of unknown function (DUF382)
- Curation status
- SEEDED
- Seed status
- UNKNOWN CANDIDATE
- Characterization
- UNSCORED
Grounding
PF04037: Domain of unknown function (DUF382)
IPR007180: integrated entry for Domain of unknown function (DUF382)
Source description
This domain is specific to the human splicing factor 3b subunit 2 and it's orthologues. Splicing factor 3b subunit 2 or SAP145 is a suppressor of U2 snRNA mutations. Pre-mRNA splicing is catalysed by a large ribonucleoprotein complex called the spliceosome. Spliceosomes are multi-component enzymes that catalyse pre-mRNA splicing and form step-wise by the ordered interaction of UsnRNPs and non-snRNP proteins with short conserved regions of the pre-mRNA at the 5' and 3' splice sites and branch site [InterPro reference PUB00013034].
Evidence and references
- InterPro entry and its literature references. PUB identifiers are internal InterPro references, not PubMed identifiers. Unresolved citations link to the originating entry.
- Frozen description source: InterPro/Pfam API
Source descriptions and links are provenance, not independent functional validation.
Evidence counts: not scored.
Curated functional assertions
No curated functional assertions supplied.
Protein sequence examples
3 verified sequence examples. FASTA
| UniProt | Protein / organism | Sequence | Provenance |
|---|---|---|---|
| Q02554 | Cold sensitive U2 snRNA suppressor 1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 436 aa; version 1 UniProt 2026_03 | UNIPROT FETCH |
| Q13435 | Splicing factor 3B subunit 2 Homo sapiens | 895 aa; version 2 UniProt 2026_03 | PTM REGISTRY MIRROR |
| Q3UJB0 | Splicing factor 3B subunit 2 Mus musculus | 878 aa; version 1 UniProt 2026_03 | UNIPROT FETCH |
Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.
Sequences and metadata: UniProt Consortium, CC BY 4.0.
Domain matches
No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.
Snapshot counters
- proteins
- 4,347
- matches
- 4,397
- proteomes
- 3,033
- taxa
- 8,016
- structures
- 57
- alphafold models
- 3,682
- domain architectures
- 60
Classification basis
short name matches duf; name says unknown function; domain of unknown function
No scoring reasons supplied.
Related Mech records
| Family | Mech | Record | Protein | Link basis |
|---|---|---|---|---|
| DUF382 (PF04037) | ProteinTraitsMech | Domain of unknown function DUF382 | Q02554 Cold sensitive U2 snRNA suppressor 1 | canonical example family classification |
| DUF382 (PF04037) | ProteinTraitsMech | Domain of unknown function DUF382 | Q13435 Splicing factor 3B subunit 2 | canonical example family classification |
| DUF382 (PF04037) | ProteinTraitsMech | Domain of unknown function DUF382 | Q3UJB0 Splicing factor 3B subunit 2 | canonical example family classification |
| DUF382 (PF04037) | ProteinTraitsMech | Domain of unknown function DUF382 | trait identifier | |
| DUF382 (PF04037) | ProteinTraitsMech | PSP, proline-rich | Q02554 Cold sensitive U2 snRNA suppressor 1 | canonical example family classification |
| DUF382 (PF04037) | ProteinTraitsMech | PSP, proline-rich | Q13435 Splicing factor 3B subunit 2 | canonical example family classification |
| DUF382 (PF04037) | ProteinTraitsMech | PSP, proline-rich | Q3UJB0 Splicing factor 3B subunit 2 | canonical example family classification |
| DUF382 (PF04037) | ProteinTraitsMech | SAP domain | Q13435 Splicing factor 3B subunit 2 | canonical example family classification |
| DUF382 (PF04037) | ProteinTraitsMech | SAP domain | Q13435 Splicing factor 3B subunit 2 | canonical example family classification |
| DUF382 (PF04037) | ProteinTraitsMech | Domain of unknown function (DUF382) | Q02554 Cold sensitive U2 snRNA suppressor 1 | canonical example family classification |
| DUF382 (PF04037) | ProteinTraitsMech | Domain of unknown function (DUF382) | Q13435 Splicing factor 3B subunit 2 | canonical example family classification |
| DUF382 (PF04037) | ProteinTraitsMech | Domain of unknown function (DUF382) | Q3UJB0 Splicing factor 3B subunit 2 | canonical example family classification |
| DUF382 (PF04037) | ProteinTraitsMech | Domain of unknown function (DUF382) | trait identifier | |
| DUF382 (PF04037) | ProteinTraitsMech | PSP | Q02554 Cold sensitive U2 snRNA suppressor 1 | canonical example family classification |
| DUF382 (PF04037) | ProteinTraitsMech | PSP | Q13435 Splicing factor 3B subunit 2 | canonical example family classification |
| DUF382 (PF04037) | ProteinTraitsMech | PSP | Q3UJB0 Splicing factor 3B subunit 2 | canonical example family classification |
| DUF382 (PF04037) | ProteinTraitsMech | SAP motif profile | Q13435 Splicing factor 3B subunit 2 | canonical example family classification |
| DUF382 (PF04037) | ProteinTraitsMech | SAP motif profile | Q3UJB0 Splicing factor 3B subunit 2 | canonical example family classification |
Curation history and reviews
No retained curation events supplied.
No retained review supplied.
Record source
Status and evidence
- Seed status
- A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
- Characterization
- A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
- Evidence counts
- Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
- Curation status
- Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
- Missing counts
- Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.