All families / PF04149
PF04149: DUF397
Domain of unknown function (DUF397)
- Curation status
- SEEDED
- Seed status
- UNKNOWN CANDIDATE
- Characterization
- UNSCORED
Grounding
PF04149: Domain of unknown function (DUF397)
IPR007278: integrated entry for Domain of unknown function (DUF397)
Source description
The function of this family is unknown.
Evidence and references
Source descriptions and links are provenance, not independent functional validation.
Evidence counts: not scored.
Curated functional assertions
No curated functional assertions supplied.
Protein sequence examples
No sibling protein candidate in the scanned commits.
Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.
Sequences and metadata: UniProt Consortium, CC BY 4.0.
Domain matches
Observed Pfam match ranges on supplied protein sequences; these are sequence coordinates, not a three-dimensional structure. Coordinates are one-based and inclusive. Only members in the supplied snapshot are shown; this is not a complete family alignment.
Snapshot counters
- proteins
- 37,657
- matches
- 40,691
- proteomes
- 1,831
- taxa
- 2,162
- structures
- 0
- alphafold models
- 19,000
- domain architectures
- 25
Classification basis
short name matches duf; name says unknown function; description says unknown function; domain of unknown function
No scoring reasons supplied.
Related Mech records
| Family | Mech | Record | Protein | Link basis |
|---|---|---|---|---|
| DUF397 (PF04149) | ProteinTraitsMech | Domain of unknown function DUF397 | trait identifier | |
| DUF397 (PF04149) | ProteinTraitsMech | Domain of unknown function (DUF397) | trait identifier |
Curation history and reviews
- Codex: REVIEW. Completed a scoped PF04149 frozen-seed and native audit integration review; biological content unchanged. history/records/PF04149/2026-10-07T122602Z-codex-3e2c16.yaml
Saved reports/yaml_record_review/20261007T122924Z-PF04149.md with verdict SEED_ONLY and scientific_review false. Verified PF04149/DUF397/InterPro:IPR007278 identity and all frozen counters, strict worklist and two-member manifest provenance, native FamilyRecord validation against synchronized schemas, and a full 6532-record baseline dry run with zero drift. The review finished at 2026-10-07T12:29:24Z against HEAD 611617feeda7ac0480898e7042bbd2fb4bdaf930 plus recorded working-tree inputs. No primary functional evidence was assessed and no biological claim, overlay, SEEDED status, or UNSCORED status was changed. The semantic digest before this bookkeeping append was b294554d93d69202f55e68bec9614b6f0b8c6abf544981c6548e2c347580ec35. The generated read-only event index will be refreshed separately through the native builder; this sidecar remains authoritative. This event records actual completed scoped review, not scientific endorsement or REVIEWED promotion. no_change
- 2026-10-07T07:24:23.895662Z: SEED_ONLY by Codex (GPT-6), scoped implementation audit
Scope: Two explicitly selected frozen rows: identity, evidence categories, and lump/split triage.. Scientific review: False.
- 2026-10-07T07:24:23.895662Z: SEED_ONLY by Codex (GPT-6), scoped implementation audit
Scope: Frozen-row identity, source integrity, and evidence-completeness triage only.. Scientific review: False.
- 2026-10-07T08:06:30Z: SEED_ONLY by Codex (GPT-5 coding agent), independent scoped reviewer
Scope: Offline identity, frozen-source provenance and generated-record integrity of candidate working-tree PF04149; no biological functional characterization or live-source verification.. Scientific review: False.
- 2026-10-07T12:29:24Z: SEED_ONLY by Codex (GPT-5 coding agent; scoped implementation reviewer)
Scope: Offline PF04149 identity, frozen-input provenance, evidence inventory, and native schema/history-index integration audit; no live-source verification, functional literature review, or scientific endorsement.. Scientific review: False.
Record source
Status and evidence
- Seed status
- A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
- Characterization
- A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
- Evidence counts
- Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
- Curation status
- Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
- Missing counts
- Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.