All families / PF04379
PF04379: DUF525
ApaG domain
- Curation status
- SEEDED
- Seed status
- KNOWN HISTORICAL DUF
- Characterization
- UNSCORED
Grounding
PF04379: ApaG domain
IPR007474: integrated entry for ApaG domain
Source description
The apaG domain is a ~125 amino acids domain present in bacterial apaG proteins and in eukaryotic F-box proteins. The domain is named after the bacterial apaG protein, of which it forms the core. The domain also occurs in the C-terminal part of eukaryotic proteins with an N-terminal F-box domain. The Salmonella typhimurium apaG domain protein corD is involved in Co(2+) resistance and Mg(2+) efflux. Tertiary structures from different apaG proteins show a fold of several beta-sheets. The apaG domain may be involved in protein-protein interactions which could be implicated in substrate-specificity [InterPro reference PUB00009972,InterPro reference PUB00016988,InterPro reference PUB00018539,InterPro reference PUB00016989].
Evidence and references
- InterPro entry and its literature references. PUB identifiers are internal InterPro references, not PubMed identifiers. Unresolved citations link to the originating entry.
- Frozen description source: InterPro/Pfam API
Source descriptions and links are provenance, not independent functional validation.
Evidence counts: not scored.
Curated functional assertions
No curated functional assertions supplied.
Protein sequence examples
6 verified sequence examples. FASTA
Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.
Sequences and metadata: UniProt Consortium, CC BY 4.0.
Domain matches
No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.
Snapshot counters
- proteins
- 11,744
- matches
- 11,776
- proteomes
- 9,065
- taxa
- 15,356
- structures
- 9
- alphafold models
- 8,600
- domain architectures
- 67
Classification basis
short name matches duf
No scoring reasons supplied.
Related Mech records
| Family | Mech | Record | Protein | Link basis |
|---|---|---|---|---|
| DUF525 (PF04379) | ProteinTraitsMech | vascular associated smooth muscle cell proliferation | Q91VA6 Polymerase delta-interacting protein 2 | canonical example family classification |
| DUF525 (PF04379) | ProteinTraitsMech | vascular associated smooth muscle cell proliferation | Q9Y2S7 Polymerase delta-interacting protein 2 | canonical example family classification |
| DUF525 (PF04379) | ProteinTraitsMech | Co2+/Mg2+ efflux protein ApaG | P62672 Protein ApaG | canonical example family classification |
| DUF525 (PF04379) | ProteinTraitsMech | Co2+/Mg2+ efflux protein ApaG | Q91VA6 Polymerase delta-interacting protein 2 | canonical example family classification |
| DUF525 (PF04379) | ProteinTraitsMech | Co2+/Mg2+ efflux protein ApaG | Q9Y2S7 Polymerase delta-interacting protein 2 | canonical example family classification |
| DUF525 (PF04379) | ProteinTraitsMech | ApaG domain | P62672 Protein ApaG | canonical example family classification |
| DUF525 (PF04379) | ProteinTraitsMech | ApaG domain | Q91VA6 Polymerase delta-interacting protein 2 | canonical example family classification |
| DUF525 (PF04379) | ProteinTraitsMech | ApaG domain | Q9LND7 F-box protein SKIP16 | canonical example family classification |
| DUF525 (PF04379) | ProteinTraitsMech | ApaG domain | Q9Y2S7 Polymerase delta-interacting protein 2 | canonical example family classification |
| DUF525 (PF04379) | ProteinTraitsMech | ApaG domain | trait identifier | |
| DUF525 (PF04379) | ProteinTraitsMech | Hemimethylated DNA-binding domain | Q91VA6 Polymerase delta-interacting protein 2 | canonical example family classification |
| DUF525 (PF04379) | ProteinTraitsMech | Hemimethylated DNA-binding domain | Q9Y2S7 Polymerase delta-interacting protein 2 | canonical example family classification |
| DUF525 (PF04379) | ProteinTraitsMech | Hemimethylated DNA-binding protein YccV like | Q91VA6 Polymerase delta-interacting protein 2 | canonical example family classification |
| DUF525 (PF04379) | ProteinTraitsMech | Hemimethylated DNA-binding protein YccV like | Q9Y2S7 Polymerase delta-interacting protein 2 | canonical example family classification |
| DUF525 (PF04379) | ProteinTraitsMech | ApaG domain | Q91VA6 Polymerase delta-interacting protein 2 | canonical example family classification |
| DUF525 (PF04379) | ProteinTraitsMech | ApaG domain | Q9UK99 F-box only protein 3 | canonical example family classification |
| DUF525 (PF04379) | ProteinTraitsMech | ApaG domain | Q9Y2S7 Polymerase delta-interacting protein 2 | canonical example family classification |
| DUF525 (PF04379) | ProteinTraitsMech | ApaG domain | trait identifier | |
| DUF525 (PF04379) | ProteinTraitsMech | ApaG domain superfamily | P62672 Protein ApaG | canonical example family classification |
| DUF525 (PF04379) | ProteinTraitsMech | ApaG domain superfamily | Q91VA6 Polymerase delta-interacting protein 2 | canonical example family classification |
| DUF525 (PF04379) | ProteinTraitsMech | ApaG domain superfamily | Q9LND7 F-box protein SKIP16 | canonical example family classification |
| DUF525 (PF04379) | ProteinTraitsMech | ApaG domain superfamily | Q9Y2S7 Polymerase delta-interacting protein 2 | canonical example family classification |
| DUF525 (PF04379) | ProteinTraitsMech | Hemimethylated DNA-binding domain superfamily | Q91VA6 Polymerase delta-interacting protein 2 | canonical example family classification |
| DUF525 (PF04379) | ProteinTraitsMech | Hemimethylated DNA-binding domain superfamily | Q9Y2S7 Polymerase delta-interacting protein 2 | canonical example family classification |
| DUF525 (PF04379) | ProteinTraitsMech | ApaG domain profile | P62672 Protein ApaG | canonical example family classification |
| DUF525 (PF04379) | ProteinTraitsMech | ApaG domain profile | Q91VA6 Polymerase delta-interacting protein 2 | canonical example family classification |
| DUF525 (PF04379) | ProteinTraitsMech | ApaG domain profile | Q9LND7 F-box protein SKIP16 | canonical example family classification |
| DUF525 (PF04379) | ProteinTraitsMech | ApaG domain profile | Q9Y2S7 Polymerase delta-interacting protein 2 | canonical example family classification |
| DUF525 (PF04379) | ProteinTraitsMech | ApaG domain | P62672 Protein ApaG | canonical example family classification |
| DUF525 (PF04379) | ProteinTraitsMech | ApaG domain | Q91VA6 Polymerase delta-interacting protein 2 | canonical example family classification |
| DUF525 (PF04379) | ProteinTraitsMech | ApaG domain | Q9LND7 F-box protein SKIP16 | canonical example family classification |
| DUF525 (PF04379) | ProteinTraitsMech | ApaG domain | Q9Y2S7 Polymerase delta-interacting protein 2 | canonical example family classification |
Curation history and reviews
No retained curation events supplied.
No retained review supplied.
Record source
Status and evidence
- Seed status
- A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
- Characterization
- A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
- Evidence counts
- Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
- Curation status
- Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
- Missing counts
- Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.