All families / PF05071
PF05071: NDUFA12
NADH ubiquinone oxidoreductase subunit NDUFA12
- Curation status
- SEEDED
- Seed status
- UNKNOWN CANDIDATE
- Characterization
- UNSCORED
Grounding
PF05071: NADH ubiquinone oxidoreductase subunit NDUFA12
IPR007763: integrated entry for NADH ubiquinone oxidoreductase subunit NDUFA12
Source description
This family contains the 17.2 kD subunit of complex I (NDUFA12) and its homologues. The family also contains a second related eukaryotic protein of unknown function, e.g. Q9BV02 (UniProtKB protein).
Evidence and references
Source descriptions and links are provenance, not independent functional validation.
Evidence counts: not scored.
Curated functional assertions
No curated functional assertions supplied.
Protein sequence examples
6 verified sequence examples. FASTA
| UniProt | Protein / organism | Sequence | Provenance |
|---|---|---|---|
| Q59J78 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2 Mus musculus | 168 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| Q7TMF3 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 Mus musculus | 145 aa; version 2 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| Q8N183 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2 Homo sapiens | 169 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| Q9M9M9 | Probable NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 Arabidopsis thaliana | 159 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| Q9N2W7 | Probable NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 Caenorhabditis elegans | 146 aa; version 2 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| Q9UI09 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 Homo sapiens | 145 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.
Sequences and metadata: UniProt Consortium, CC BY 4.0.
Domain matches
No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.
Snapshot counters
- proteins
- 9,214
- matches
- 9,228
- proteomes
- 5,704
- taxa
- 11,992
- structures
- 291
- alphafold models
- 7,460
- domain architectures
- 92
Classification basis
description says unknown function
No scoring reasons supplied.
Related Mech records
| Family | Mech | Record | Protein | Link basis |
|---|---|---|---|---|
| NDUFA12 (PF05071) | ProteinTraitsMech | NADH ubiquinone oxidoreductase subunit NDUFA12 | Q59J78 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2 | canonical example family classification |
| NDUFA12 (PF05071) | ProteinTraitsMech | NADH ubiquinone oxidoreductase subunit NDUFA12 | Q7TMF3 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 | canonical example family classification |
| NDUFA12 (PF05071) | ProteinTraitsMech | NADH ubiquinone oxidoreductase subunit NDUFA12 | Q8N183 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2 | canonical example family classification |
| NDUFA12 (PF05071) | ProteinTraitsMech | NADH ubiquinone oxidoreductase subunit NDUFA12 | Q9M9M9 Probable NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 | canonical example family classification |
| NDUFA12 (PF05071) | ProteinTraitsMech | NADH ubiquinone oxidoreductase subunit NDUFA12 | Q9N2W7 Probable NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 | canonical example family classification |
| NDUFA12 (PF05071) | ProteinTraitsMech | NADH ubiquinone oxidoreductase subunit NDUFA12 | Q9UI09 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 | canonical example family classification |
| NDUFA12 (PF05071) | ProteinTraitsMech | NADH ubiquinone oxidoreductase subunit NDUFA12 | trait identifier |
Curation history and reviews
No retained curation events supplied.
No retained review supplied.
Record source
Status and evidence
- Seed status
- A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
- Characterization
- A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
- Evidence counts
- Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
- Curation status
- Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
- Missing counts
- Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.