PF05078: DUF679

Protein of unknown function (DUF679)

Curation status: SEEDED
Seed status: UNKNOWN CANDIDATE
Characterization: UNSCORED

Grounding

PF05078: Protein of unknown function (DUF679)
IPR007770: integrated entry for Protein of unknown function (DUF679)

Source description

This family includes members such as plant proteins AtDMPs 1-10 (Arabidopsis thaliana DUF679 domain membrane proteins 1 -10) [InterPro reference PUB00136742]. The AtDMP proteins are predicted to have four transmembrane spans, with cytosolic amino- and carboxy-termini. DMP1 is a membrane protein that may be involved in membrane fission during breakdown of the ER and the tonoplast during leaf senescence and in membrane fusion during vacuole biogenesis in roots [InterPro reference PUB00086645]. Several DMP proteins are expressed in senescing organs (DMP1, -3, -4) or tissues that will stall later in development (DMP1, -2, -4, -7). These expression patterns strongly suggest involvement of several DMPs in various programmed cell death processes, e.g. senescence, dehiscence and abscission [InterPro reference PUB00136742]. AtDMP8 and AtDMP9 however, have been shown to facilitate gamete fusion during double fertilisation in flowering plants [InterPro reference PUB00093467].

Evidence and references

InterPro entry and its literature references. PUB identifiers are internal InterPro references, not PubMed identifiers. Unresolved citations link to the originating entry.
Frozen description source: InterPro/Pfam API

Source descriptions and links are provenance, not independent functional validation.

Evidence counts: not scored.

Curated functional assertions

No curated functional assertions supplied.

Protein sequence examples

7 verified sequence examples. FASTA

UniProt	Protein / organism	Sequence	Provenance
O80493	Protein DMP8 Arabidopsis thaliana	243 aa; version 1 UniProt 2026_03	PTM REGISTRY MIRROR 3 sibling references ProteinTraitsMech: GO:0061936 ProteinTraitsMech: Pfam:PF05078 ProteinTraitsMech: UniProtKB:O80493
Q5XV67	Protein DMP7 Arabidopsis thaliana	200 aa; version 1 UniProt 2026_03	UNIPROT FETCH 2 sibling references ProteinTraitsMech: GO:0009838 ProteinTraitsMech: GO:0009900
Q8L928	Protein DMP4 Arabidopsis thaliana	213 aa; version 1 UniProt 2026_03	UNIPROT FETCH 2 sibling references ProteinTraitsMech: GO:0009838 ProteinTraitsMech: GO:0090693
Q9FK96	Protein DMP9 Arabidopsis thaliana	244 aa; version 1 UniProt 2026_03	UNIPROT FETCH 3 sibling references ProteinTraitsMech: GO:0010256 ProteinTraitsMech: GO:0061936 ProteinTraitsMech: Pfam:PF05078
Q9LVF1	Protein DMP2 Arabidopsis thaliana	184 aa; version 1 UniProt 2026_03	UNIPROT FETCH 1 sibling references ProteinTraitsMech: GO:0009838
Q9LVF4	Protein DMP1 Arabidopsis thaliana	207 aa; version 1 UniProt 2026_03	UNIPROT FETCH 3 sibling references ProteinTraitsMech: GO:0010256 ProteinTraitsMech: GO:0090693 ProteinTraitsMech: Pfam:PF05078
Q9STW3	Protein DMP3 Arabidopsis thaliana	213 aa; version 1 UniProt 2026_03	UNIPROT FETCH 1 sibling references ProteinTraitsMech: GO:0090693

Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.

Sequences and metadata: UniProt Consortium, CC BY 4.0.

Domain matches

No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.

Snapshot counters

proteins: 4,584
matches: 4,715
proteomes: 395
taxa: 1,097
structures: 0
alphafold models: 3,757
domain architectures: 52

Classification basis

short name matches duf; name says unknown function

No scoring reasons supplied.

Related Mech records

Family	Mech	Record	Protein	Link basis
DUF679 (PF05078)	ProteinTraitsMech	abscission	Q5XV67 Protein DMP7	canonical example family classification
DUF679 (PF05078)	ProteinTraitsMech	abscission	Q8L928 Protein DMP4	canonical example family classification
DUF679 (PF05078)	ProteinTraitsMech	abscission	Q9LVF1 Protein DMP2	canonical example family classification
DUF679 (PF05078)	ProteinTraitsMech	dehiscence	Q5XV67 Protein DMP7	canonical example family classification
DUF679 (PF05078)	ProteinTraitsMech	endomembrane system organization	Q9FK96 Protein DMP9	canonical example family classification
DUF679 (PF05078)	ProteinTraitsMech	endomembrane system organization	Q9LVF4 Protein DMP1	canonical example family classification
DUF679 (PF05078)	ProteinTraitsMech	fusion of sperm to egg plasma membrane involved in double fertilization forming a zygote and endosperm	O80493 Protein DMP8	canonical example family classification
DUF679 (PF05078)	ProteinTraitsMech	fusion of sperm to egg plasma membrane involved in double fertilization forming a zygote and endosperm	Q9FK96 Protein DMP9	canonical example family classification
DUF679 (PF05078)	ProteinTraitsMech	plant organ senescence	Q8L928 Protein DMP4	canonical example family classification
DUF679 (PF05078)	ProteinTraitsMech	plant organ senescence	Q9LVF4 Protein DMP1	canonical example family classification
DUF679 (PF05078)	ProteinTraitsMech	plant organ senescence	Q9STW3 Protein DMP3	canonical example family classification
DUF679 (PF05078)	ProteinTraitsMech	Protein of unknown function (DUF679)	O80493 Protein DMP8	canonical example family classification
DUF679 (PF05078)	ProteinTraitsMech	Protein of unknown function (DUF679)	Q9FK96 Protein DMP9	canonical example family classification
DUF679 (PF05078)	ProteinTraitsMech	Protein of unknown function (DUF679)	Q9LVF4 Protein DMP1	canonical example family classification
DUF679 (PF05078)	ProteinTraitsMech	Protein of unknown function (DUF679)		trait identifier

Curation history and reviews

No retained curation events supplied.

No retained review supplied.

Record source

data/families/PF05078.yaml
Family YAML in this build

Download this family (JSON)

Status and evidence

Seed status: A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
Characterization: A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
Evidence counts: Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
Curation status: Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
Missing counts: Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.