All families / PF05346
PF05346: DUF747
Eukaryotic membrane protein family
- Curation status
- SEEDED
- Seed status
- KNOWN HISTORICAL DUF
- Characterization
- UNSCORED
Grounding
PF05346: Eukaryotic membrane protein family
IPR008010: integrated entry for Eukaryotic membrane protein family
Source description
This family is a family of eukaryotic membrane proteins. It was previously annotated as including a putative receptor for human cytomegalovirus gH [InterPro reference PUB00019476] but this has has since been disputed [InterPro reference PUB00044752]. Analysis of the mouse Tapt1 protein (transmembrane anterior posterior transformation 1) has shown it to be involved in patterning of the vertebrate axial skeleton.
Evidence and references
- InterPro entry and its literature references. PUB identifiers are internal InterPro references, not PubMed identifiers. Unresolved citations link to the originating entry.
- Frozen description source: InterPro/Pfam API
Source descriptions and links are provenance, not independent functional validation.
Evidence counts: not scored.
Curated functional assertions
No curated functional assertions supplied.
Protein sequence examples
4 verified sequence examples. FASTA
| UniProt | Protein / organism | Sequence | Provenance |
|---|---|---|---|
| A2BIE7 | Transmembrane anterior posterior transformation protein 1 homolog Danio rerio | 567 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| F4HVJ3 | Protein POLLEN DEFECTIVE IN GUIDANCE 1 Arabidopsis thaliana | 624 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| Q4VBD2 | Transmembrane anterior posterior transformation protein 1 Mus musculus | 564 aa; version 2 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| Q6NXT6 | Transmembrane anterior posterior transformation protein 1 homolog Homo sapiens | 567 aa; version 1 UniProt 2026_03 | PTM REGISTRY MIRROR |
Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.
Sequences and metadata: UniProt Consortium, CC BY 4.0.
Domain matches
No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.
Snapshot counters
- proteins
- 4,804
- matches
- 4,980
- proteomes
- 3,258
- taxa
- 8,637
- structures
- 0
- alphafold models
- 4,083
- domain architectures
- 84
Classification basis
short name matches duf
No scoring reasons supplied.
Related Mech records
| Family | Mech | Record | Protein | Link basis |
|---|---|---|---|---|
| DUF747 (PF05346) | ProteinTraitsMech | growth hormone-releasing hormone receptor activity | Q6NXT6 Transmembrane anterior posterior transformation protein 1 homolog | canonical example family classification |
| DUF747 (PF05346) | ProteinTraitsMech | positive regulation of bone development | Q4VBD2 Transmembrane anterior posterior transformation protein 1 | canonical example family classification |
| DUF747 (PF05346) | ProteinTraitsMech | positive regulation of bone development | Q6NXT6 Transmembrane anterior posterior transformation protein 1 homolog | canonical example family classification |
| DUF747 (PF05346) | ProteinTraitsMech | Eukaryotic membrane protein family | A2BIE7 Transmembrane anterior posterior transformation protein 1 homolog | canonical example family classification |
| DUF747 (PF05346) | ProteinTraitsMech | Eukaryotic membrane protein family | F4HVJ3 Protein POLLEN DEFECTIVE IN GUIDANCE 1 | canonical example family classification |
| DUF747 (PF05346) | ProteinTraitsMech | Eukaryotic membrane protein family | Q6NXT6 Transmembrane anterior posterior transformation protein 1 homolog | canonical example family classification |
| DUF747 (PF05346) | ProteinTraitsMech | Eukaryotic membrane protein family | trait identifier |
Curation history and reviews
No retained curation events supplied.
No retained review supplied.
Record source
Status and evidence
- Seed status
- A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
- Characterization
- A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
- Evidence counts
- Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
- Curation status
- Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
- Missing counts
- Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.