PF05620: TMEM208_SND2

SRP-independent targeting protein 2/TMEM208

Curation status: SEEDED
Seed status: EX DUF
Characterization: UNSCORED

Grounding

PF05620: SRP-independent targeting protein 2/TMEM208
IPR008506: integrated entry for SRP-independent targeting protein 2/TMEM208

Source description

This family includes SRP-independent targeting protein 2 (SND2) from yeast and transmembrane protein 208 (TMEM208) from mammals. Both are localized to the endoplasmic reticulum (ER) [InterPro reference PUB00083911,InterPro reference PUB00083915]. SND2 works together with SND1 and SND3 in an alternative targeting route to the ER [InterPro reference PUB00083911]. TMEM208 regulates both ER stress and autophagy. It contains three predicted transmembrane regions [InterPro reference PUB00083915]. SND2 also known as Env10 in Saccharomyces cerevisiae, and its homologue as Mug69 in Schizosaccharomyces pombe. They were identified as proteins involved in vacuolar processing and morphology [InterPro reference PUB00066964] and meiosis [InterPro reference PUB00044889], respectively.

Evidence and references

InterPro entry and its literature references. PUB identifiers are internal InterPro references, not PubMed identifiers. Unresolved citations link to the originating entry.
Frozen description source: InterPro/Pfam API

Source descriptions and links are provenance, not independent functional validation.

Evidence counts: not scored.

Curated functional assertions

No curated functional assertions supplied.

Protein sequence examples

4 verified sequence examples. FASTA

UniProt	Protein / organism	Sequence	Provenance
A1ZA77	Transmembrane protein 208 Drosophila melanogaster	174 aa; version 1 UniProt 2026_03	UNIPROT FETCH 1 sibling references ProteinTraitsMech: Pfam:PF05620
Q99382	SRP-independent targeting protein 2 Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	181 aa; version 1 UniProt 2026_03	UNIPROT FETCH 1 sibling references ProteinTraitsMech: Pfam:PF05620
Q9BTX3	Transmembrane protein 208 Homo sapiens	173 aa; version 1 UniProt 2026_03	UNIPROT FETCH 1 sibling references ProteinTraitsMech: Pfam:PF05620
Q9CR96	Transmembrane protein 208 Mus musculus	173 aa; version 1 UniProt 2026_03	UNIPROT FETCH 1 sibling references ProteinTraitsMech: Pfam:PF05620

Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.

Sequences and metadata: UniProt Consortium, CC BY 4.0.

Domain matches

No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.

Snapshot counters

proteins: 3,823
matches: 3,893
proteomes: 3,211
taxa: 8,600
structures: 0
alphafold models: 3,288
domain architectures: 54

Classification basis

pfam previous unknown name

No scoring reasons supplied.

Related Mech records

This family joined the worklist after the frozen cross-Mech scan, so other Mechs were not searched for it. Missing links here are not evidence that other Mechs lack it; rows shown come from mentions of a former DUF/UPF name.

No cross-Mech examples are present in the supplied snapshot.

Curation history and reviews

No retained curation events supplied.

No retained review supplied.

Record source

data/families/PF05620.yaml
Family YAML in this build

Download this family (JSON)

Status and evidence

Seed status: A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
Characterization: A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
Evidence counts: Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
Curation status: Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
Missing counts: Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.