All families / PF05978
PF05978: UNC-93
Ion channel regulatory protein UNC-93
- Curation status
- SEEDED
- Seed status
- EX DUF
- Characterization
- UNSCORED
Grounding
PF05978: Ion channel regulatory protein UNC-93
IPR010291: integrated entry for Ion channel regulatory protein UNC-93
Source description
The proteins in this family are represented by UNC-93 from Caenorhabditis elegans and also includes protein unc-93 homologue A (UNC93A), protein unc-93 homologue B1 (UNC93B1), and UNC93-like protein MFSD11 (also called major facilitator superfamily domain- containing protein 11 or protein ET). UNC-93 colocalizes with SUP-10 and SUP-9 within muscle cells. UNC-93 acts as a regulatory subunit of a multi-subunit potassium channel complex that may function in coordinating muscle contraction in C. elegans [InterPro reference PUB00053696]. UNC93B1 controls intracellular trafficking and transport of a subset of Toll-like receptors (TLRs), including TLR3, TLR7 and TLR9, from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades [InterPro reference PUB00097046]. MFSD11 is ubiquitously expressed in the periphery and the central nervous system of mice, where it is expressed in excitatory and inhibitory mouse brain neurons [InterPro reference PUB00097045].
Evidence and references
- InterPro entry and its literature references. PUB identifiers are internal InterPro references, not PubMed identifiers. Unresolved citations link to the originating entry.
- Frozen description source: InterPro/Pfam API
Source descriptions and links are provenance, not independent functional validation.
Evidence counts: not scored.
Curated functional assertions
No curated functional assertions supplied.
Protein sequence examples
9 verified sequence examples. FASTA
| UniProt | Protein / organism | Sequence | Provenance |
|---|---|---|---|
| O43934 | UNC93-like protein MFSD11 Homo sapiens | 449 aa; version 2 UniProt 2026_03 | UNIPROT FETCH2 sibling references |
| Q56WD3 | UNC93-like protein 1 Arabidopsis thaliana | 459 aa; version 2 UniProt 2026_03 | UNIPROT FETCH2 sibling references |
| Q710D3 | N-acetylglucosamine transporter UNC93A Mus musculus | 458 aa; version 1 UniProt 2026_03 | UNIPROT FETCH |
| Q86WB7 | N-acetylglucosamine transporter UNC93A Homo sapiens | 457 aa; version 1 UniProt 2026_03 | PTM REGISTRY MIRROR |
| Q8BJ51 | UNC93-like protein MFSD11 Mus musculus | 449 aa; version 1 UniProt 2026_03 | UNIPROT FETCH2 sibling references |
| Q8LG53 | UNC93-like protein 2 Arabidopsis thaliana | 459 aa; version 2 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| Q93380 | Putative potassium channel regulatory protein unc-93 Caenorhabditis elegans | 705 aa; version 4 UniProt 2026_03 | UNIPROT FETCH2 sibling references |
| Q94AA1 | UNC93-like protein 3 Arabidopsis thaliana | 464 aa; version 1 UniProt 2026_03 | UNIPROT FETCH2 sibling references |
| Q9Y115 | UNC93-like protein Drosophila melanogaster | 538 aa; version 1 UniProt 2026_03 | UNIPROT FETCH |
Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.
Sequences and metadata: UniProt Consortium, CC BY 4.0.
Domain matches
No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.
Snapshot counters
- proteins
- 11,159
- matches
- 11,823
- proteomes
- 2,949
- taxa
- 8,050
- structures
- 0
- alphafold models
- 9,617
- domain architectures
- 156
Classification basis
pfam previous unknown name
No scoring reasons supplied.
Related Mech records
This family joined the worklist after the frozen cross-Mech scan, so other Mechs were not searched for it. Missing links here are not evidence that other Mechs lack it; rows shown come from mentions of a former DUF/UPF name.
No cross-Mech examples are present in the supplied snapshot.
Curation history and reviews
No retained curation events supplied.
No retained review supplied.
Record source
Status and evidence
- Seed status
- A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
- Characterization
- A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
- Evidence counts
- Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
- Curation status
- Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
- Missing counts
- Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.