PF06672: MagC

MagC peptidoglycan-binding NlpC/P60-like protein

Curation status: SEEDED
Seed status: EX DUF
Characterization: UNSCORED

Grounding

PF06672: MagC peptidoglycan-binding NlpC/P60-like protein
IPR009558: integrated entry for MagC peptidoglycan-binding NlpC/P60-like protein

Source description

This family represents MagC and related proteins that adopt an NlpC/P60-like fold but are catalytically inactive [InterPro reference PUB00164055]. The structure consists of a six-stranded beta-sheet and five alpha-helices with a Cys-His-His catalytic triad characteristic of NlpC/P60 peptidases. However, a conserved tryptophan residue distorts the active site conformation, rendering these proteins unable to cleave peptidoglycan while retaining the ability to bind it [InterPro reference PUB00164055]. In Pseudomonas aeruginosa, MagC is part of a type II alpha-2- macroglobulin complex encoded by the magABCDEF operon, where it directly interacts with the macroglobulin MagD [InterPro reference PUB00164055]. These proteins are proposed to anchor the macroglobulin complex to the peptidoglycan layer in the bacterial periplasm [InterPro reference PUB00164055].

Evidence and references

InterPro entry and its literature references. PUB identifiers are internal InterPro references, not PubMed identifiers. Unresolved citations link to the originating entry.
Frozen description source: InterPro/Pfam API

Source descriptions and links are provenance, not independent functional validation.

Evidence counts: not scored.

Curated functional assertions

No curated functional assertions supplied.

Protein sequence examples

1 verified sequence example. FASTA

UniProt	Protein / organism	Sequence	Provenance
P76466	Uncharacterized protein YfaT Escherichia coli (strain K12)	207 aa; version 2 UniProt 2026_03	UNIPROT FETCH 1 sibling references ProteinTraitsMech: Pfam:PF06672

Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.

Sequences and metadata: UniProt Consortium, CC BY 4.0.

Domain matches

No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.

Snapshot counters

proteins: 436
matches: 476
proteomes: 430
taxa: 664
structures: 1
alphafold models: 252
domain architectures: 4

Classification basis

pfam previous unknown name

No scoring reasons supplied.

Related Mech records

This family joined the worklist after the frozen cross-Mech scan, so other Mechs were not searched for it. Missing links here are not evidence that other Mechs lack it; rows shown come from mentions of a former DUF/UPF name.

No cross-Mech examples are present in the supplied snapshot.

Curation history and reviews

No retained curation events supplied.

No retained review supplied.

Record source

data/families/PF06672.yaml
Family YAML in this build

Download this family (JSON)

Status and evidence

Seed status: A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
Characterization: A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
Evidence counts: Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
Curation status: Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
Missing counts: Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.