All families / PF07000
PF07000: DUF1308
Protein of unknown function (DUF1308)
- Curation status
- SEEDED
- Seed status
- UNKNOWN CANDIDATE
- Characterization
- UNSCORED
Grounding
PF07000: Protein of unknown function (DUF1308)
IPR010733: integrated entry for Protein of unknown function (DUF1308)
Source description
This is a domain of unknown function found on the C-terminal of C7orf25 protein UPF0415. The C-terminal domain is homologous to the known PIN-like domains. The PIN-like domain is widespread among eukaryotes, including animals, plants, and fungi, but also present in some cyanobacteria, Deinococcus, and dsDNA viruses from the Mimiviridae family. The domain retains up to four potential catalytic residues, thus, depending on the protein is predicted to be an active or inactive nuclease and in a majority of the family members, the PIN-like domain is N-terminally fused with a potentially active PD-(D/E)XK-like domain PF18474 (Family of unknown function (DUF5614)) [InterPro reference PUB00091006].
Evidence and references
- InterPro entry and its literature references. PUB identifiers are internal InterPro references, not PubMed identifiers. Unresolved citations link to the originating entry.
- Frozen description source: InterPro/Pfam API
Source descriptions and links are provenance, not independent functional validation.
Evidence counts: not scored.
Curated functional assertions
No curated functional assertions supplied.
Protein sequence examples
5 verified sequence examples. FASTA
| UniProt | Protein / organism | Sequence | Provenance |
|---|---|---|---|
| Q1LZE8 | UPF0415 protein C7orf25 homolog Bos taurus | 421 aa; version 1 UniProt 2026_03 | UNIPROT FETCH2 sibling references |
| Q5M888 | UPF0415 protein C7orf25 homolog Rattus norvegicus | 421 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| Q803H0 | UPF0415 protein C7orf25 homolog Danio rerio | 427 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| Q91WD4 | UPF0415 protein C7orf25 homolog Mus musculus | 421 aa; version 1 UniProt 2026_03 | UNIPROT FETCH2 sibling references |
| Q9BPX7 | UPF0415 protein C7orf25 Homo sapiens | 421 aa; version 1 UniProt 2026_03 | UNIPROT FETCH |
Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.
Sequences and metadata: UniProt Consortium, CC BY 4.0.
Domain matches
No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.
Snapshot counters
- proteins
- 2,550
- matches
- 2,576
- proteomes
- 2,155
- taxa
- 6,269
- structures
- 0
- alphafold models
- 2,190
- domain architectures
- 49
Classification basis
short name matches duf; name says unknown function; description says unknown function; domain of unknown function
No scoring reasons supplied.
Related Mech records
| Family | Mech | Record | Protein | Link basis |
|---|---|---|---|---|
| DUF1308 (PF07000) | ProteinTraitsMech | Domain of unknown function DUF1308 | Q91WD4 UPF0415 protein C7orf25 homolog | canonical example family classification |
| DUF1308 (PF07000) | ProteinTraitsMech | Domain of unknown function DUF1308 | Q9BPX7 UPF0415 protein C7orf25 | canonical example family classification |
| DUF1308 (PF07000) | ProteinTraitsMech | Domain of unknown function DUF1308 | trait identifier | |
| DUF1308 (PF07000) | ProteinTraitsMech | Domain of unknown function DUF5614 | Q91WD4 UPF0415 protein C7orf25 homolog | canonical example family classification |
| DUF1308 (PF07000) | ProteinTraitsMech | Domain of unknown function DUF5614 | Q9BPX7 UPF0415 protein C7orf25 | canonical example family classification |
| DUF1308 (PF07000) | ProteinTraitsMech | Protein of unknown function (DUF1308) | Q1LZE8 UPF0415 protein C7orf25 homolog | canonical example family classification |
| DUF1308 (PF07000) | ProteinTraitsMech | Protein of unknown function (DUF1308) | Q5M888 UPF0415 protein C7orf25 homolog | canonical example family classification |
| DUF1308 (PF07000) | ProteinTraitsMech | Protein of unknown function (DUF1308) | Q9BPX7 UPF0415 protein C7orf25 | canonical example family classification |
| DUF1308 (PF07000) | ProteinTraitsMech | Protein of unknown function (DUF1308) | trait identifier | |
| DUF1308 (PF07000) | ProteinTraitsMech | Family of unknown function (DUF5614) | Q1LZE8 UPF0415 protein C7orf25 homolog | canonical example family classification |
| DUF1308 (PF07000) | ProteinTraitsMech | Family of unknown function (DUF5614) | Q803H0 UPF0415 protein C7orf25 homolog | canonical example family classification |
| DUF1308 (PF07000) | ProteinTraitsMech | Family of unknown function (DUF5614) | Q9BPX7 UPF0415 protein C7orf25 | canonical example family classification |
Curation history and reviews
No retained curation events supplied.
No retained review supplied.
Record source
Status and evidence
- Seed status
- A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
- Characterization
- A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
- Evidence counts
- Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
- Curation status
- Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
- Missing counts
- Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.