All families / PF07564
PF07564: DUF1542
Domain of Unknown Function (DUF1542)
- Curation status
- SEEDED
- Seed status
- UNKNOWN CANDIDATE
- Characterization
- UNSCORED
Grounding
PF07564: Domain of Unknown Function (DUF1542)
IPR011439: integrated entry for Domain of Unknown Function (DUF1542)
Source description
This domain is found in several cell surface proteins, such as extracellular matrix-binding protein ebh [InterPro reference PUB00014728]. Some members are involved in antibiotic resistance (e.g Q9RL69 (UniProtKB protein) and Q9LCJ9 (UniProtKB protein)) [InterPro reference PUB00014727] and/or cellular adhesion (e.g. Q931R6 (UniProtKB protein)) [InterPro reference PUB00014728]. In some proteins it is repeated more than fifteen times, being the most repeated domain in streptococci [InterPro reference PUB00097824]. This is a predominantly alpha-helical domain that form a long, thin, fibre-like structure and it has been proposed to function as a stalk that helps the adhesive non-repeat region (NRR) of proteins protrude beyond the cell surface [InterPro reference PUB00097823,InterPro reference PUB00065268].
Evidence and references
- InterPro entry and its literature references. PUB identifiers are internal InterPro references, not PubMed identifiers. Unresolved citations link to the originating entry.
- Frozen description source: InterPro/Pfam API
Source descriptions and links are provenance, not independent functional validation.
Evidence counts: not scored.
Curated functional assertions
No curated functional assertions supplied.
Protein sequence examples
3 verified sequence examples. FASTA
| UniProt | Protein / organism | Sequence | Provenance |
|---|---|---|---|
| A7X2C3 | Extracellular matrix-binding protein EbhA Staphylococcus aureus (strain Mu3 / ATCC 700698) | 6713 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| Q2FYJ6 | Extracellular matrix-binding protein ebh Staphylococcus aureus (strain NCTC 8325 / PS 47) | 9535 aa; version 1 UniProt 2026_03 | UNIPROT FETCH2 sibling references |
| Q5HPA2 | Extracellular matrix-binding protein ebh Staphylococcus epidermidis (strain ATCC 35984 / DSM 28319 / BCRC 17069 / CCUG 31568 / BM 3577 / RP62A) | 9439 aa; version 2 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.
Sequences and metadata: UniProt Consortium, CC BY 4.0.
Domain matches
No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.
Snapshot counters
- proteins
- 393
- matches
- 2,712
- proteomes
- 153
- taxa
- 310
- structures
- 0
- alphafold models
- 112
- domain architectures
- 192
Classification basis
short name matches duf; name says unknown function; domain of unknown function
No scoring reasons supplied.
Related Mech records
| Family | Mech | Record | Protein | Link basis |
|---|---|---|---|---|
| DUF1542 (PF07564) | ProteinTraitsMech | Domain of unknown function DUF1542 | trait identifier | |
| DUF1542 (PF07564) | ProteinTraitsMech | Domain of Unknown Function (DUF1542) | A7X2C3 Extracellular matrix-binding protein EbhA | canonical example family classification |
| DUF1542 (PF07564) | ProteinTraitsMech | Domain of Unknown Function (DUF1542) | Q2FYJ6 Extracellular matrix-binding protein ebh | canonical example family classification |
| DUF1542 (PF07564) | ProteinTraitsMech | Domain of Unknown Function (DUF1542) | Q5HPA2 Extracellular matrix-binding protein ebh | canonical example family classification |
| DUF1542 (PF07564) | ProteinTraitsMech | Domain of Unknown Function (DUF1542) | trait identifier | |
| DUF1542 (PF07564) | ProteinTraitsMech | GA module | Q2FYJ6 Extracellular matrix-binding protein ebh | canonical example family classification |
Curation history and reviews
No retained curation events supplied.
No retained review supplied.
Record source
Status and evidence
- Seed status
- A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
- Characterization
- A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
- Evidence counts
- Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
- Curation status
- Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
- Missing counts
- Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.