All families / PF07773
PF07773: TCTN_DUF1619
Tectonic domain of DUF1619
- Curation status
- SEEDED
- Seed status
- KNOWN HISTORICAL DUF
- Characterization
- UNSCORED
Grounding
PF07773: Tectonic domain of DUF1619
IPR011677: integrated entry for Tectonic domain of DUF1619
Source description
This is a conserved domain found in tectonic proteins (TCTN1/2/3) which contains conserved cysteine residues predicted to form disulfide bond. This domain is found in two tandem copies. It is predicted to fold into an alpha/beta structure with unique topology composed of a central mixed beta-sheet and alpha-helix packed on it. Although function of this domain is currently unknown, studies on TCTN2 suggest that it is indispensable for its functions [InterPro reference PUB00097826,InterPro reference PUB00097827]. TCTN1, TCTN2, and TCTN3 are members of the tectonic protein family that play crucial roles in ciliogenesis and ciliary function. While they share some common functions, each protein also has specific roles in the process of cilia formation and maintenance. These proteins interact with several other ciliopathy proteins, forming a complex known as the Tectonic ciliopathy complex. This complex is required for hedgehog signalling transduction and regulation of ciliary membrane composition [InterPro reference PUB00069722,InterPro reference PUB00160606].
Evidence and references
- InterPro entry and its literature references. PUB identifiers are internal InterPro references, not PubMed identifiers. Unresolved citations link to the originating entry.
- Frozen description source: InterPro/Pfam API
Source descriptions and links are provenance, not independent functional validation.
Evidence counts: not scored.
Curated functional assertions
No curated functional assertions supplied.
Protein sequence examples
7 verified sequence examples. FASTA
| UniProt | Protein / organism | Sequence | Provenance |
|---|---|---|---|
| Q2MV57 | Tectonic-2 Mus musculus | 700 aa; version 2 UniProt 2026_03 | UNIPROT FETCH |
| Q2MV58 | Tectonic-1 Homo sapiens | 587 aa; version 2 UniProt 2026_03 | UNIPROT FETCH |
| Q6NUS6 | Tectonic-3 Homo sapiens | 607 aa; version 2 UniProt 2026_03 | UNIPROT FETCH |
| Q8BZ64 | Tectonic-1 Mus musculus | 593 aa; version 1 UniProt 2026_03 | PTM REGISTRY MIRROR |
| Q8R2Q6 | Tectonic-3 Mus musculus | 595 aa; version 1 UniProt 2026_03 | UNIPROT FETCH |
| Q96GX1 | Tectonic-2 Homo sapiens | 697 aa; version 1 UniProt 2026_03 | UNIPROT FETCH |
| Q9VMH0 | Tectonic Drosophila melanogaster | 657 aa; version 4 UniProt 2026_03 | UNIPROT FETCH |
Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.
Sequences and metadata: UniProt Consortium, CC BY 4.0.
Domain matches
No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.
Snapshot counters
- proteins
- 3,441
- matches
- 6,251
- proteomes
- 1,145
- taxa
- 3,864
- structures
- 0
- alphafold models
- 2,961
- domain architectures
- 51
Classification basis
name matches duf
No scoring reasons supplied.
Related Mech records
| Family | Mech | Record | Protein | Link basis |
|---|---|---|---|---|
| TCTN_DUF1619 (PF07773) | ProteinTraitsMech | central nervous system interneuron axonogenesis | Q8BZ64 Tectonic-1 | canonical example family classification |
| TCTN_DUF1619 (PF07773) | ProteinTraitsMech | somatic motor neuron differentiation | Q8BZ64 Tectonic-1 | canonical example family classification |
| TCTN_DUF1619 (PF07773) | ProteinTraitsMech | Y-shaped link assembly | Q9VMH0 Tectonic | canonical example family classification |
| TCTN_DUF1619 (PF07773) | ProteinTraitsMech | Tectonic-1-3 domain | Q2MV57 Tectonic-2 | canonical example family classification |
| TCTN_DUF1619 (PF07773) | ProteinTraitsMech | Tectonic-1-3 domain | Q2MV58 Tectonic-1 | canonical example family classification |
| TCTN_DUF1619 (PF07773) | ProteinTraitsMech | Tectonic-1-3 domain | Q6NUS6 Tectonic-3 | canonical example family classification |
| TCTN_DUF1619 (PF07773) | ProteinTraitsMech | Tectonic-1-3 domain | Q8BZ64 Tectonic-1 | canonical example family classification |
| TCTN_DUF1619 (PF07773) | ProteinTraitsMech | Tectonic-1-3 domain | Q8R2Q6 Tectonic-3 | canonical example family classification |
| TCTN_DUF1619 (PF07773) | ProteinTraitsMech | Tectonic-1-3 domain | Q96GX1 Tectonic-2 | canonical example family classification |
| TCTN_DUF1619 (PF07773) | ProteinTraitsMech | Tectonic-1-3 domain | Q9VMH0 Tectonic | canonical example family classification |
| TCTN_DUF1619 (PF07773) | ProteinTraitsMech | Tectonic-1-3 domain | trait identifier | |
| TCTN_DUF1619 (PF07773) | ProteinTraitsMech | Tectonic-1-3, N-terminal domain | Q2MV57 Tectonic-2 | canonical example family classification |
| TCTN_DUF1619 (PF07773) | ProteinTraitsMech | Tectonic-1-3, N-terminal domain | Q2MV58 Tectonic-1 | canonical example family classification |
| TCTN_DUF1619 (PF07773) | ProteinTraitsMech | Tectonic-1-3, N-terminal domain | Q6NUS6 Tectonic-3 | canonical example family classification |
| TCTN_DUF1619 (PF07773) | ProteinTraitsMech | Tectonic-1-3, N-terminal domain | Q8BZ64 Tectonic-1 | canonical example family classification |
| TCTN_DUF1619 (PF07773) | ProteinTraitsMech | Tectonic-1-3, N-terminal domain | Q8R2Q6 Tectonic-3 | canonical example family classification |
| TCTN_DUF1619 (PF07773) | ProteinTraitsMech | Tectonic-1-3, N-terminal domain | Q96GX1 Tectonic-2 | canonical example family classification |
| TCTN_DUF1619 (PF07773) | ProteinTraitsMech | Tectonic-1-3, N-terminal domain | Q9VMH0 Tectonic | canonical example family classification |
| TCTN_DUF1619 (PF07773) | ProteinTraitsMech | N-terminal domain of DUF1619 | Q2MV58 Tectonic-1 | canonical example family classification |
| TCTN_DUF1619 (PF07773) | ProteinTraitsMech | N-terminal domain of DUF1619 | Q6NUS6 Tectonic-3 | canonical example family classification |
| TCTN_DUF1619 (PF07773) | ProteinTraitsMech | N-terminal domain of DUF1619 | Q96GX1 Tectonic-2 | canonical example family classification |
| TCTN_DUF1619 (PF07773) | ProteinTraitsMech | Tectonic domain of DUF1619 | Q2MV57 Tectonic-2 | canonical example family classification |
| TCTN_DUF1619 (PF07773) | ProteinTraitsMech | Tectonic domain of DUF1619 | Q2MV58 Tectonic-1 | canonical example family classification |
| TCTN_DUF1619 (PF07773) | ProteinTraitsMech | Tectonic domain of DUF1619 | Q6NUS6 Tectonic-3 | canonical example family classification |
| TCTN_DUF1619 (PF07773) | ProteinTraitsMech | Tectonic domain of DUF1619 | Q8BZ64 Tectonic-1 | canonical example family classification |
| TCTN_DUF1619 (PF07773) | ProteinTraitsMech | Tectonic domain of DUF1619 | Q8R2Q6 Tectonic-3 | canonical example family classification |
| TCTN_DUF1619 (PF07773) | ProteinTraitsMech | Tectonic domain of DUF1619 | Q96GX1 Tectonic-2 | canonical example family classification |
| TCTN_DUF1619 (PF07773) | ProteinTraitsMech | Tectonic domain of DUF1619 | Q9VMH0 Tectonic | canonical example family classification |
| TCTN_DUF1619 (PF07773) | ProteinTraitsMech | Tectonic domain of DUF1619 | trait identifier |
Curation history and reviews
No retained curation events supplied.
No retained review supplied.
Record source
Status and evidence
- Seed status
- A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
- Characterization
- A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
- Evidence counts
- Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
- Curation status
- Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
- Missing counts
- Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.