PF10300: Iml2-TPR_39

Iml2/Tetratricopeptide repeat protein 39

Curation status: SEEDED
Seed status: EX DUF
Characterization: UNSCORED

Grounding

PF10300: Iml2/Tetratricopeptide repeat protein 39
IPR019412: integrated entry for Iml2/Tetratricopeptide repeat protein 39

Source description

This is a family of proteins conserved from fungi to humans, including fungal Inclusion body clearance protein Iml2 protein, animal tetratricopeptide repeat protein 39A/B/C (TT39A/B/C) and some uncharacterised proteins. Members of this family carry a tetratricopeptide repeat PF07719 (Pfam entry) at their C terminus. This entry includes Iml2 and its paralogue-YKR018C from S. cerevisiae; Iml2 localises to the cytoplasm and nucleus [InterPro reference PUB00016470], and its expression is increased in response to DNA replication stress [InterPro reference PUB00066967]. It is found to be involved in lipid droplet-mediated inclusion body clearing after protein folding stress [InterPro reference PUB00088292]. In humans, TTC39A (also known as DEME6) is expressed in primary breast carcinomas but not in normal breast tissue, and has a putative eukaryotic RNP-1 RNA binding region and a candidate anchoring transmembrane domain. It is coordinately regulated with oestrogen receptor, but is not necessarily oestradiol-responsive [InterPro reference PUB00044224]. TTC39B has been linked to lipid metabolism [InterPro reference PUB00072592].

Evidence and references

InterPro entry and its literature references. PUB identifiers are internal InterPro references, not PubMed identifiers. Unresolved citations link to the originating entry.
Frozen description source: InterPro/Pfam API

Source descriptions and links are provenance, not independent functional validation.

Evidence counts: not scored.

Curated functional assertions

No curated functional assertions supplied.

Protein sequence examples

5 verified sequence examples. FASTA

UniProt	Protein / organism	Sequence	Provenance
P47031	Inclusion body clearance protein IML2 Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	731 aa; version 1 UniProt 2026_03	UNIPROT FETCH 1 sibling references ProteinTraitsMech: Pfam:PF10300
Q5VTQ0	Tetratricopeptide repeat protein 39B Homo sapiens	682 aa; version 4 UniProt 2026_03	UNIPROT FETCH 1 sibling references ProteinTraitsMech: Pfam:PF10300
Q8BYY4	Tetratricopeptide repeat protein 39B Mus musculus	617 aa; version 1 UniProt 2026_03	UNIPROT FETCH 1 sibling references ProteinTraitsMech: Pfam:PF10300
Q8N584	Tetratricopeptide repeat protein 39C Homo sapiens	583 aa; version 2 UniProt 2026_03	UNIPROT FETCH 1 sibling references ProteinTraitsMech: GO:0032474
Q8VE09	Tetratricopeptide repeat protein 39C Mus musculus	580 aa; version 2 UniProt 2026_03	UNIPROT FETCH 1 sibling references ProteinTraitsMech: GO:0032474

Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.

Sequences and metadata: UniProt Consortium, CC BY 4.0.

Domain matches

No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.

Snapshot counters

proteins: 9,006
matches: 9,867
proteomes: 2,835
taxa: 7,559
structures: 0
alphafold models: 7,859
domain architectures: 143

Classification basis

pfam previous unknown name

No scoring reasons supplied.

Related Mech records

This family joined the worklist after the frozen cross-Mech scan, so other Mechs were not searched for it. Missing links here are not evidence that other Mechs lack it; rows shown come from mentions of a former DUF/UPF name.

No cross-Mech examples are present in the supplied snapshot.

Curation history and reviews

No retained curation events supplied.

No retained review supplied.

Record source

data/families/PF10300.yaml
Family YAML in this build

Download this family (JSON)

Status and evidence

Seed status: A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
Characterization: A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
Evidence counts: Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
Curation status: Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
Missing counts: Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.