All families / PF10937
PF10937: Kgd4-YMR31
Alpha-ketoglutarate dehydrogenase component 4/YMR-31
- Curation status
- SEEDED
- Seed status
- EX DUF
- Characterization
- UNSCORED
Grounding
PF10937: Alpha-ketoglutarate dehydrogenase component 4/YMR-31
IPR020373: integrated entry for Alpha-ketoglutarate dehydrogenase component 4/YMR-31
Source description
This entry represents the alpha-ketoglutarate dehydrogenase component 4 (Kgd4, also referred to as Ymr31/MRPS36) which was originally identified as a subunit of the mitochondrial ribosome [InterPro reference PUB00056057,InterPro reference PUB00012961,InterPro reference PUB00010175]. Through biochemical studies, it was shown that this protein co purifies with the oxoglutarate dehydrogenase complex (OGDC). Both mitochondrial ribosome 28S subunit and OGDC have a similar size and OGDC is highly abundant, being found to contaminate ribosomal preparations [InterPro reference PUB00089008]. Kgd4 plays an evolutionarily conserved role in the organisation of mitochondrial alpha-KGDH complexes of fungi and animals which constitutes a molecular adaptor that is necessary to form a stable alpha-KGDH enzyme complex [InterPro reference PUB00089008,InterPro reference PUB00100356].
Evidence and references
- InterPro entry and its literature references. PUB identifiers are internal InterPro references, not PubMed identifiers. Unresolved citations link to the originating entry.
- Frozen description source: InterPro/Pfam API
Source descriptions and links are provenance, not independent functional validation.
Evidence counts: not scored.
Curated functional assertions
No curated functional assertions supplied.
Protein sequence examples
3 verified sequence examples. FASTA
| UniProt | Protein / organism | Sequence | Provenance |
|---|---|---|---|
| G2TRP3 | Alpha-ketoglutarate dehydrogenase subunit 4, mitochondrial Schizosaccharomyces pombe (strain 972 / ATCC 24843) | 89 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| P19955 | Alpha-ketoglutarate dehydrogenase subunit 4, mitochondrial Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 123 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| Q9CQX8 | Alpha-ketoglutarate dehydrogenase component 4 Mus musculus | 102 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.
Sequences and metadata: UniProt Consortium, CC BY 4.0.
Domain matches
No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.
Snapshot counters
- proteins
- 1,927
- matches
- 1,958
- proteomes
- 1,742
- taxa
- 4,549
- structures
- 0
- alphafold models
- 1,635
- domain architectures
- 23
Classification basis
pfam previous unknown name
No scoring reasons supplied.
Related Mech records
This family joined the worklist after the frozen cross-Mech scan, so other Mechs were not searched for it. Missing links here are not evidence that other Mechs lack it; rows shown come from mentions of a former DUF/UPF name.
No cross-Mech examples are present in the supplied snapshot.
Curation history and reviews
No retained curation events supplied.
No retained review supplied.
Record source
Status and evidence
- Seed status
- A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
- Characterization
- A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
- Evidence counts
- Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
- Curation status
- Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
- Missing counts
- Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.