DUFMech

All families / PF11738

PF11738: DUF3298

Protein of unknown function (DUF3298)

Curation status
SEEDED
Seed status
UNKNOWN CANDIDATE
Characterization
UNSCORED

Grounding

PF11738: Protein of unknown function (DUF3298)
IPR021729: integrated entry for Protein of unknown function (DUF3298)

Source description

This family of bacterial protein C-terminal regions is highly conserved but the function is not known. Several members are annotated as being endo-1,4-beta-xylanase-like, but this could not be confirmed, and the structure can be defined as a heat-shock cognate 70kd protein 44kd ATPase.

Evidence and references

Source descriptions and links are provenance, not independent functional validation.

Evidence counts: not scored.

Curated functional assertions

No curated functional assertions supplied.

Protein sequence examples

3 verified sequence examples. FASTA

UniProtProtein / organismSequenceProvenance
I6YF08Esterase Rv3036c
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
227 aa; version 1
UniProt 2026_03
UNIPROT FETCH
1 sibling references
O05403Anti-sigma-V factor RsiV
Bacillus subtilis (strain 168)
285 aa; version 1
UniProt 2026_03
PTM REGISTRY MIRROR
8 sibling references
O34798Peptidoglycan-N-acetylmuramic acid deacetylase PdaC
Bacillus subtilis (strain 168)
467 aa; version 1
UniProt 2026_03
UNIPROT FETCH
8 sibling references

Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.

Sequences and metadata: UniProt Consortium, CC BY 4.0.

Domain matches

No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.

Snapshot counters

proteins
6,617
matches
6,649
proteomes
4,704
taxa
6,583
structures
5
alphafold models
4,154
domain architectures
60

Classification basis

short name matches duf; name says unknown function

No scoring reasons supplied.

Related Mech records

FamilyMechRecordProteinLink basis
DUF3298 (PF11738)ProteinTraitsMechCE4_SpPgdA_BsYjeA_likeO34798
Peptidoglycan-N-acetylmuramic acid deacetylase PdaC
canonical example family classification
DUF3298 (PF11738)ProteinTraitsMechDeacetylase PdaCO05403
Anti-sigma-V factor RsiV
canonical example family classification
DUF3298 (PF11738)ProteinTraitsMechDeacetylase PdaCO34798
Peptidoglycan-N-acetylmuramic acid deacetylase PdaC
canonical example family classification
DUF3298 (PF11738)ProteinTraitsMechDomain of unknown function DUF3298O05403
Anti-sigma-V factor RsiV
canonical example family classification
DUF3298 (PF11738)ProteinTraitsMechDomain of unknown function DUF3298O34798
Peptidoglycan-N-acetylmuramic acid deacetylase PdaC
canonical example family classification
DUF3298 (PF11738)ProteinTraitsMechDomain of unknown function DUF3298
trait identifier
DUF3298 (PF11738)ProteinTraitsMechProtein of unknown function (DUF3298)I6YF08
Esterase Rv3036c
canonical example family classification
DUF3298 (PF11738)ProteinTraitsMechProtein of unknown function (DUF3298)O05403
Anti-sigma-V factor RsiV
canonical example family classification
DUF3298 (PF11738)ProteinTraitsMechProtein of unknown function (DUF3298)O34798
Peptidoglycan-N-acetylmuramic acid deacetylase PdaC
canonical example family classification
DUF3298 (PF11738)ProteinTraitsMechProtein of unknown function (DUF3298)
trait identifier
DUF3298 (PF11738)ProteinTraitsMechDeacetylase PdaCO05403
Anti-sigma-V factor RsiV
canonical example family classification
DUF3298 (PF11738)ProteinTraitsMechDeacetylase PdaCO34798
Peptidoglycan-N-acetylmuramic acid deacetylase PdaC
canonical example family classification
DUF3298 (PF11738)ProteinTraitsMechPdaC/RsiV-like superfamilyO05403
Anti-sigma-V factor RsiV
canonical example family classification
DUF3298 (PF11738)ProteinTraitsMechPdaC/RsiV-like superfamilyO34798
Peptidoglycan-N-acetylmuramic acid deacetylase PdaC
canonical example family classification
DUF3298 (PF11738)ProteinTraitsMechFervidobacterium nodosum Rt17-B1 likeO05403
Anti-sigma-V factor RsiV
canonical example family classification
DUF3298 (PF11738)ProteinTraitsMechFervidobacterium nodosum Rt17-B1 likeO34798
Peptidoglycan-N-acetylmuramic acid deacetylase PdaC
canonical example family classification
DUF3298 (PF11738)ProteinTraitsMechHeat-shock cognate protein, ATPaseO05403
Anti-sigma-V factor RsiV
canonical example family classification
DUF3298 (PF11738)ProteinTraitsMechHeat-shock cognate protein, ATPaseO34798
Peptidoglycan-N-acetylmuramic acid deacetylase PdaC
canonical example family classification

Curation history and reviews

No retained curation events supplied.

No retained review supplied.

Record source

data/families/PF11738.yaml
Family YAML in this build

Download this family (JSON)

Status and evidence

Seed status
A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
Characterization
A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
Evidence counts
Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
Curation status
Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
Missing counts
Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.