All families / PF11861
PF11861: DUF3381
Ribosomal RNA methyltransferase Spb1, DUF3381
- Curation status
- SEEDED
- Seed status
- KNOWN HISTORICAL DUF
- Characterization
- UNSCORED
Grounding
PF11861: Ribosomal RNA methyltransferase Spb1, DUF3381
IPR024576: integrated entry for Ribosomal RNA methyltransferase Spb1, DUF3381
Source description
This domain is functionally uncharacterised and it is found in the central region of fungal SPB1 and mammalian homologue FTSJ3. This domain is found associated with PF07780 (Pfam entry), PF01728 (Pfam entry). SPB1 is an adoMet-dependent rRNA methyltransferase required for proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit [InterPro reference PUB00016377]. FTSJ3, SPB1 homologue in humans, is associated with NIP7 (involved in the biogenesis of 40S subunit) and functions in pre-rRNA processing [InterPro reference PUB00068805].
Evidence and references
- InterPro entry and its literature references. PUB identifiers are internal InterPro references, not PubMed identifiers. Unresolved citations link to the originating entry.
- Frozen description source: InterPro/Pfam API
Source descriptions and links are provenance, not independent functional validation.
Evidence counts: not scored.
Curated functional assertions
No curated functional assertions supplied.
Protein sequence examples
3 verified sequence examples. FASTA
| UniProt | Protein / organism | Sequence | Provenance |
|---|---|---|---|
| P25582 | 27S pre-rRNA (guanosine(2922)-2'-O)-methyltransferase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 841 aa; version 2 UniProt 2026_03 | UNIPROT FETCH |
| Q8IY81 | pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3 Homo sapiens | 847 aa; version 2 UniProt 2026_03 | UNIPROT FETCH |
| Q9DBE9 | pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3 Mus musculus | 838 aa; version 1 UniProt 2026_03 | UNIPROT FETCH |
Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.
Sequences and metadata: UniProt Consortium, CC BY 4.0.
Domain matches
No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.
Snapshot counters
- proteins
- 3,891
- matches
- 3,912
- proteomes
- 3,174
- taxa
- 8,437
- structures
- 35
- alphafold models
- 3,292
- domain architectures
- 77
Classification basis
short name matches duf
No scoring reasons supplied.
Related Mech records
| Family | Mech | Record | Protein | Link basis |
|---|---|---|---|---|
| DUF3381 (PF11861) | ProteinTraitsMech | RNA 2'-O-methyltransferase activity | Q8IY81 pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3 | canonical example family classification |
| DUF3381 (PF11861) | ProteinTraitsMech | RNA 2'-O-methyltransferase activity | Q9DBE9 pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3 | canonical example family classification |
| DUF3381 (PF11861) | ProteinTraitsMech | rRNA (guanine) methyltransferase activity | P25582 27S pre-rRNA (guanosine(2922)-2'-O)-methyltransferase | canonical example family classification |
| DUF3381 (PF11861) | ProteinTraitsMech | rRNA (guanine) methyltransferase activity | Q8IY81 pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3 | canonical example family classification |
| DUF3381 (PF11861) | ProteinTraitsMech | rRNA (guanine) methyltransferase activity | Q9DBE9 pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3 | canonical example family classification |
| DUF3381 (PF11861) | ProteinTraitsMech | rRNA (guanosine-2'-O-ribose)-methyltransferase activity | P25582 27S pre-rRNA (guanosine(2922)-2'-O)-methyltransferase | canonical example family classification |
| DUF3381 (PF11861) | ProteinTraitsMech | rRNA (uridine-2'-O-ribose)-methyltransferase activity | P25582 27S pre-rRNA (guanosine(2922)-2'-O)-methyltransferase | canonical example family classification |
| DUF3381 (PF11861) | ProteinTraitsMech | rRNA (uridine-2'-O-ribose)-methyltransferase activity | Q8IY81 pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3 | canonical example family classification |
| DUF3381 (PF11861) | ProteinTraitsMech | rRNA (uridine-2'-O-ribose)-methyltransferase activity | Q9DBE9 pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3 | canonical example family classification |
| DUF3381 (PF11861) | ProteinTraitsMech | Ribosomal RNA methyltransferase Spb1, domain of unknown function DUF3381 | P25582 27S pre-rRNA (guanosine(2922)-2'-O)-methyltransferase | canonical example family classification |
| DUF3381 (PF11861) | ProteinTraitsMech | Ribosomal RNA methyltransferase Spb1, domain of unknown function DUF3381 | Q8IY81 pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3 | canonical example family classification |
| DUF3381 (PF11861) | ProteinTraitsMech | Ribosomal RNA methyltransferase Spb1, domain of unknown function DUF3381 | Q9DBE9 pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3 | canonical example family classification |
| DUF3381 (PF11861) | ProteinTraitsMech | Ribosomal RNA methyltransferase Spb1, domain of unknown function DUF3381 | trait identifier | |
| DUF3381 (PF11861) | ProteinTraitsMech | Ribosomal RNA methyltransferase, SPB1-like, C-terminal | P25582 27S pre-rRNA (guanosine(2922)-2'-O)-methyltransferase | canonical example family classification |
| DUF3381 (PF11861) | ProteinTraitsMech | Ribosomal RNA methyltransferase, SPB1-like, C-terminal | Q8IY81 pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3 | canonical example family classification |
| DUF3381 (PF11861) | ProteinTraitsMech | Ribosomal RNA methyltransferase, SPB1-like, C-terminal | Q9DBE9 pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3 | canonical example family classification |
| DUF3381 (PF11861) | ProteinTraitsMech | Ribosomal RNA methyltransferase Spb1, DUF3381 | P25582 27S pre-rRNA (guanosine(2922)-2'-O)-methyltransferase | canonical example family classification |
| DUF3381 (PF11861) | ProteinTraitsMech | Ribosomal RNA methyltransferase Spb1, DUF3381 | Q8IY81 pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3 | canonical example family classification |
| DUF3381 (PF11861) | ProteinTraitsMech | Ribosomal RNA methyltransferase Spb1, DUF3381 | Q9DBE9 pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3 | canonical example family classification |
| DUF3381 (PF11861) | ProteinTraitsMech | Ribosomal RNA methyltransferase Spb1, DUF3381 | trait identifier | |
| DUF3381 (PF11861) | ProteinTraitsMech | Spb1 C-terminal domain | P25582 27S pre-rRNA (guanosine(2922)-2'-O)-methyltransferase | canonical example family classification |
| DUF3381 (PF11861) | ProteinTraitsMech | Spb1 C-terminal domain | Q8IY81 pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3 | canonical example family classification |
| DUF3381 (PF11861) | ProteinTraitsMech | Spb1 C-terminal domain | Q9DBE9 pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3 | canonical example family classification |
| DUF3381 (PF11861) | ProteinTraitsMech | FtsJ-like methyltransferase | Q8IY81 pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3 | canonical example family classification |
Curation history and reviews
No retained curation events supplied.
No retained review supplied.
Record source
Status and evidence
- Seed status
- A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
- Characterization
- A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
- Evidence counts
- Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
- Curation status
- Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
- Missing counts
- Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.