All families / PF11928
PF11928: DUF3446
Early growth response N-terminal domain
- Curation status
- SEEDED
- Seed status
- KNOWN HISTORICAL DUF
- Characterization
- UNSCORED
Grounding
PF11928: Early growth response N-terminal domain
IPR021849: integrated entry for Early growth response N-terminal domain
Source description
Proteins containing this domain include early growth response protein 1/2/3 (EGR1/2/3). EGR1 is a transcriptional regulator that binds specifically to 9-bp target sequences containing two CpG sites that can potentially be methylated at four cytosine bases [InterPro reference PUB00086408]. EGR2, also known as Krox20, is an E3 ligase that sumoylates its Nab coregulators [InterPro reference PUB00086407]. This domain has a single completely conserved residue P that may be functionally important. Furthermore, it is found associated with PF00096 (Pfam entry).
Evidence and references
- InterPro entry and its literature references. PUB identifiers are internal InterPro references, not PubMed identifiers. Unresolved citations link to the originating entry.
- Frozen description source: InterPro/Pfam API
Source descriptions and links are provenance, not independent functional validation.
Evidence counts: not scored.
Curated functional assertions
No curated functional assertions supplied.
Protein sequence examples
7 verified sequence examples. FASTA
Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.
Sequences and metadata: UniProt Consortium, CC BY 4.0.
Domain matches
No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.
Snapshot counters
- proteins
- 2,563
- matches
- 2,576
- proteomes
- 717
- taxa
- 2,470
- structures
- 2
- alphafold models
- 2,221
- domain architectures
- 14
Classification basis
short name matches duf
No scoring reasons supplied.
Related Mech records
| Family | Mech | Record | Protein | Link basis |
|---|---|---|---|---|
| DUF3446 (PF11928) | ProteinTraitsMech | double-stranded methylated DNA binding | P08046 Early growth response protein 1 | canonical example family classification |
| DUF3446 (PF11928) | ProteinTraitsMech | double-stranded methylated DNA binding | P18146 Early growth response protein 1 | canonical example family classification |
| DUF3446 (PF11928) | ProteinTraitsMech | hemi-methylated DNA-binding | P08046 Early growth response protein 1 | canonical example family classification |
| DUF3446 (PF11928) | ProteinTraitsMech | hemi-methylated DNA-binding | P18146 Early growth response protein 1 | canonical example family classification |
| DUF3446 (PF11928) | ProteinTraitsMech | SUMO ligase activity | P08152 E3 SUMO-protein ligase EGR2 | canonical example family classification |
| DUF3446 (PF11928) | ProteinTraitsMech | SUMO ligase activity | P11161 E3 SUMO-protein ligase EGR2 | canonical example family classification |
| DUF3446 (PF11928) | ProteinTraitsMech | brain segmentation | P08152 E3 SUMO-protein ligase EGR2 | canonical example family classification |
| DUF3446 (PF11928) | ProteinTraitsMech | cellular response to heparin | P08046 Early growth response protein 1 | canonical example family classification |
| DUF3446 (PF11928) | ProteinTraitsMech | cellular response to heparin | P18146 Early growth response protein 1 | canonical example family classification |
| DUF3446 (PF11928) | ProteinTraitsMech | cellular response to interleukin-8 | P08046 Early growth response protein 1 | canonical example family classification |
| DUF3446 (PF11928) | ProteinTraitsMech | cellular response to interleukin-8 | P18146 Early growth response protein 1 | canonical example family classification |
| DUF3446 (PF11928) | ProteinTraitsMech | cellular response to mycophenolic acid | P08046 Early growth response protein 1 | canonical example family classification |
| DUF3446 (PF11928) | ProteinTraitsMech | cellular response to mycophenolic acid | P18146 Early growth response protein 1 | canonical example family classification |
| DUF3446 (PF11928) | ProteinTraitsMech | circadian temperature homeostasis | P08046 Early growth response protein 1 | canonical example family classification |
| DUF3446 (PF11928) | ProteinTraitsMech | circadian temperature homeostasis | P18146 Early growth response protein 1 | canonical example family classification |
| DUF3446 (PF11928) | ProteinTraitsMech | estrous cycle | P08046 Early growth response protein 1 | canonical example family classification |
| DUF3446 (PF11928) | ProteinTraitsMech | estrous cycle | P18146 Early growth response protein 1 | canonical example family classification |
| DUF3446 (PF11928) | ProteinTraitsMech | facial nerve structural organization | P08152 E3 SUMO-protein ligase EGR2 | canonical example family classification |
| DUF3446 (PF11928) | ProteinTraitsMech | facial nerve structural organization | P11161 E3 SUMO-protein ligase EGR2 | canonical example family classification |
| DUF3446 (PF11928) | ProteinTraitsMech | glomerular mesangial cell proliferation | P08046 Early growth response protein 1 | canonical example family classification |
| DUF3446 (PF11928) | ProteinTraitsMech | glomerular mesangial cell proliferation | P18146 Early growth response protein 1 | canonical example family classification |
| DUF3446 (PF11928) | ProteinTraitsMech | interleukin-1-mediated signaling pathway | P08046 Early growth response protein 1 | canonical example family classification |
| DUF3446 (PF11928) | ProteinTraitsMech | interleukin-1-mediated signaling pathway | P18146 Early growth response protein 1 | canonical example family classification |
| DUF3446 (PF11928) | ProteinTraitsMech | positive regulation of gene expression via chromosomal CpG island demethylation | P08046 Early growth response protein 1 | canonical example family classification |
| DUF3446 (PF11928) | ProteinTraitsMech | positive regulation of gene expression via chromosomal CpG island demethylation | P18146 Early growth response protein 1 | canonical example family classification |
| DUF3446 (PF11928) | ProteinTraitsMech | positive regulation of glomerular metanephric mesangial cell proliferation | P08046 Early growth response protein 1 | canonical example family classification |
| DUF3446 (PF11928) | ProteinTraitsMech | positive regulation of glomerular metanephric mesangial cell proliferation | P18146 Early growth response protein 1 | canonical example family classification |
| DUF3446 (PF11928) | ProteinTraitsMech | positive regulation of hormone biosynthetic process | P08046 Early growth response protein 1 | canonical example family classification |
| DUF3446 (PF11928) | ProteinTraitsMech | positive regulation of hormone biosynthetic process | P18146 Early growth response protein 1 | canonical example family classification |
| DUF3446 (PF11928) | ProteinTraitsMech | positive regulation of myelination | P08152 E3 SUMO-protein ligase EGR2 | canonical example family classification |
| DUF3446 (PF11928) | ProteinTraitsMech | positive regulation of post-translational protein modification | P08046 Early growth response protein 1 | canonical example family classification |
| DUF3446 (PF11928) | ProteinTraitsMech | positive regulation of post-translational protein modification | P18146 Early growth response protein 1 | canonical example family classification |
| DUF3446 (PF11928) | ProteinTraitsMech | positive regulation of Schwann cell differentiation | P08152 E3 SUMO-protein ligase EGR2 | canonical example family classification |
| DUF3446 (PF11928) | ProteinTraitsMech | positive regulation of Schwann cell differentiation | P11161 E3 SUMO-protein ligase EGR2 | canonical example family classification |
| DUF3446 (PF11928) | ProteinTraitsMech | regulation of gamma-delta T cell differentiation | P43300 Early growth response protein 3 | canonical example family classification |
| DUF3446 (PF11928) | ProteinTraitsMech | regulation of ossification | P08152 E3 SUMO-protein ligase EGR2 | canonical example family classification |
| DUF3446 (PF11928) | ProteinTraitsMech | regulation of progesterone biosynthetic process | P08046 Early growth response protein 1 | canonical example family classification |
| DUF3446 (PF11928) | ProteinTraitsMech | regulation of progesterone biosynthetic process | P18146 Early growth response protein 1 | canonical example family classification |
| DUF3446 (PF11928) | ProteinTraitsMech | regulation of protein sumoylation | P08046 Early growth response protein 1 | canonical example family classification |
| DUF3446 (PF11928) | ProteinTraitsMech | regulation of protein sumoylation | P18146 Early growth response protein 1 | canonical example family classification |
| DUF3446 (PF11928) | ProteinTraitsMech | rhombomere 3 development | P08152 E3 SUMO-protein ligase EGR2 | canonical example family classification |
| DUF3446 (PF11928) | ProteinTraitsMech | rhombomere 3 formation | P08152 E3 SUMO-protein ligase EGR2 | canonical example family classification |
| DUF3446 (PF11928) | ProteinTraitsMech | rhombomere 3 structural organization | P08152 E3 SUMO-protein ligase EGR2 | canonical example family classification |
| DUF3446 (PF11928) | ProteinTraitsMech | rhombomere 3 structural organization | P11161 E3 SUMO-protein ligase EGR2 | canonical example family classification |
| DUF3446 (PF11928) | ProteinTraitsMech | rhombomere 5 formation | P08152 E3 SUMO-protein ligase EGR2 | canonical example family classification |
| DUF3446 (PF11928) | ProteinTraitsMech | rhombomere 5 structural organization | P08152 E3 SUMO-protein ligase EGR2 | canonical example family classification |
| DUF3446 (PF11928) | ProteinTraitsMech | rhombomere 5 structural organization | P11161 E3 SUMO-protein ligase EGR2 | canonical example family classification |
| DUF3446 (PF11928) | ProteinTraitsMech | rhythmic behavior | P08152 E3 SUMO-protein ligase EGR2 | canonical example family classification |
| DUF3446 (PF11928) | ProteinTraitsMech | Schwann cell differentiation | P08152 E3 SUMO-protein ligase EGR2 | canonical example family classification |
| DUF3446 (PF11928) | ProteinTraitsMech | Schwann cell differentiation | P11161 E3 SUMO-protein ligase EGR2 | canonical example family classification |
| DUF3446 (PF11928) | ProteinTraitsMech | Early growth response, N-terminal | P08046 Early growth response protein 1 | canonical example family classification |
| DUF3446 (PF11928) | ProteinTraitsMech | Early growth response, N-terminal | P08152 E3 SUMO-protein ligase EGR2 | canonical example family classification |
| DUF3446 (PF11928) | ProteinTraitsMech | Early growth response, N-terminal | P11161 E3 SUMO-protein ligase EGR2 | canonical example family classification |
| DUF3446 (PF11928) | ProteinTraitsMech | Early growth response, N-terminal | P18146 Early growth response protein 1 | canonical example family classification |
| DUF3446 (PF11928) | ProteinTraitsMech | Early growth response, N-terminal | P43300 Early growth response protein 3 | canonical example family classification |
| DUF3446 (PF11928) | ProteinTraitsMech | Early growth response, N-terminal | Q06889 Early growth response protein 3 | canonical example family classification |
| DUF3446 (PF11928) | ProteinTraitsMech | Early growth response, N-terminal | trait identifier | |
| DUF3446 (PF11928) | ProteinTraitsMech | Early growth response N-terminal domain | P11161 E3 SUMO-protein ligase EGR2 | canonical example family classification |
| DUF3446 (PF11928) | ProteinTraitsMech | Early growth response N-terminal domain | P18146 Early growth response protein 1 | canonical example family classification |
| DUF3446 (PF11928) | ProteinTraitsMech | Early growth response N-terminal domain | Q06889 Early growth response protein 3 | canonical example family classification |
| DUF3446 (PF11928) | ProteinTraitsMech | Early growth response N-terminal domain | trait identifier | |
| DUF3446 (PF11928) | ProteinTraitsMech | Early growth response protein 1, C-terminal | P08046 Early growth response protein 1 | canonical example family classification |
| DUF3446 (PF11928) | ProteinTraitsMech | Early growth response protein 1, C-terminal | P18146 Early growth response protein 1 | canonical example family classification |
| DUF3446 (PF11928) | ProteinTraitsMech | Domain of unknown function (DUF3432) | P08046 Early growth response protein 1 | canonical example family classification |
| DUF3446 (PF11928) | ProteinTraitsMech | Domain of unknown function (DUF3432) | P18146 Early growth response protein 1 | canonical example family classification |
| DUF3446 (PF11928) | ProteinTraitsMech | Domain of unknown function (DUF3432) | Q29W20 Early growth response protein 1 | canonical example family classification |
Curation history and reviews
No retained curation events supplied.
No retained review supplied.
Record source
Status and evidence
- Seed status
- A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
- Characterization
- A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
- Evidence counts
- Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
- Curation status
- Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
- Missing counts
- Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.