All families / PF11998
PF11998: DUF3493
Low psii accumulation1 / Rep27
- Curation status
- SEEDED
- Seed status
- KNOWN HISTORICAL DUF
- Characterization
- UNSCORED
Grounding
PF11998: Low psii accumulation1 / Rep27
IPR021883: integrated entry for Low psii accumulation1 / Rep27
Source description
This family includes members such as low psii accumulation1 (lpa1) from plants as well as Rep27 proteins found in unicellular green alga Chlamydomonas reinhardtii. The Arabidopsis LPA1 is a chaperone required for efficient photosystem II (PSII) assembly. It binds to psbA during de novo biogenesis of PSII [InterPro reference PUB00086019]. Other studies show that REP27 in Chlamydomonas reinhardtii chloroplast thylakoids, plays a dual role in the regulation of D1 protein turnover by facilitating cotranslational biosynthesis insertion (C-terminal domain) and activation (tetratricopeptide repeat [TPR] motifs) of the nascent D1 during the PSII repair process [InterPro reference PUB00138194].
Evidence and references
- InterPro entry and its literature references. PUB identifiers are internal InterPro references, not PubMed identifiers. Unresolved citations link to the originating entry.
- Frozen description source: InterPro/Pfam API
Source descriptions and links are provenance, not independent functional validation.
Evidence counts: not scored.
Curated functional assertions
No curated functional assertions supplied.
Protein sequence examples
1 verified sequence example. FASTA
| UniProt | Protein / organism | Sequence | Provenance |
|---|---|---|---|
| Q9SRY4 | Protein LOW PSII ACCUMULATION 1, chloroplastic Arabidopsis thaliana | 453 aa; version 1 UniProt 2026_03 | UNIPROT FETCH |
Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.
Sequences and metadata: UniProt Consortium, CC BY 4.0.
Domain matches
No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.
Snapshot counters
- proteins
- 1,512
- matches
- 1,514
- proteomes
- 698
- taxa
- 1,944
- structures
- 0
- alphafold models
- 1,181
- domain architectures
- 38
Classification basis
short name matches duf
No scoring reasons supplied.
Related Mech records
| Family | Mech | Record | Protein | Link basis |
|---|---|---|---|---|
| DUF3493 (PF11998) | ProteinTraitsMech | photosystem II oxygen evolving complex assembly | Q9SRY4 Protein LOW PSII ACCUMULATION 1, chloroplastic | canonical example family classification |
| DUF3493 (PF11998) | ProteinTraitsMech | TPR end-of-group domain-containing protein | Q9SRY4 Protein LOW PSII ACCUMULATION 1, chloroplastic | canonical example family classification |
| DUF3493 (PF11998) | ProteinTraitsMech | Low psii accumulation1 / Rep27 | Q9SRY4 Protein LOW PSII ACCUMULATION 1, chloroplastic | canonical example family classification |
| DUF3493 (PF11998) | ProteinTraitsMech | Low psii accumulation1 / Rep27 | trait identifier |
Curation history and reviews
No retained curation events supplied.
No retained review supplied.
Record source
Status and evidence
- Seed status
- A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
- Characterization
- A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
- Evidence counts
- Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
- Curation status
- Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
- Missing counts
- Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.