All families / PF12257
PF12257: vWA_IML1
Vacuolar membrane-associated protein Iml1, vWA-like domain
- Curation status
- SEEDED
- Seed status
- EX DUF
- Characterization
- UNSCORED
Grounding
PF12257: Vacuolar membrane-associated protein Iml1, vWA-like domain
IPR048255: integrated entry for Vacuolar membrane-associated protein Iml1, vWA-like domain
Source description
Proteins in this entry contain a DEP domain, which is a globular domain of about 80 residues. This entry includes vacuolar membrane-associated protein Iml1 and DEP domain-containing protein 5/DDB_G0279099. In Saccharomyces cerevisiae, Iml1 is a subunit of both the SEA (Seh1-associated) and Iml1 complexes (Iml1-Npr2-Npr3). SEA complex is associates dynamically with the vacuole and is involved in autophagy [InterPro reference PUB00063317,InterPro reference PUB00063319]. Iml1 complex is required for non-nitrogen-starvation (NNS)-induced autophagy [InterPro reference PUB00063318]. This is a vWA-like domain.
Evidence and references
- InterPro entry and its literature references. PUB identifiers are internal InterPro references, not PubMed identifiers. Unresolved citations link to the originating entry.
- Frozen description source: InterPro/Pfam API
Source descriptions and links are provenance, not independent functional validation.
Evidence counts: not scored.
Curated functional assertions
No curated functional assertions supplied.
Protein sequence examples
7 verified sequence examples. FASTA
| UniProt | Protein / organism | Sequence | Provenance |
|---|---|---|---|
| A1CEE0 | Vacuolar membrane-associated protein iml1 Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107) | 1845 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| O74788 | Vacuolar membrane-associated protein iml1 Schizosaccharomyces pombe (strain 972 / ATCC 24843) | 1496 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| O75140 | GATOR1 complex protein DEPDC5 Homo sapiens | 1603 aa; version 2 UniProt 2026_03 | PTM REGISTRY MIRROR |
| P47170 | Vacuolar membrane-associated protein IML1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 1584 aa; version 1 UniProt 2026_03 | PTM REGISTRY MIRROR |
| P61460 | GATOR1 complex protein DEPDC5 Mus musculus | 1591 aa; version 2 UniProt 2026_03 | UNIPROT FETCH |
| Q6BN00 | Vacuolar membrane-associated protein IML1 Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) | 1560 aa; version 2 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| Q9W0E3 | GATOR complex protein Iml1 Drosophila melanogaster | 1544 aa; version 2 UniProt 2026_03 | UNIPROT FETCH |
Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.
Sequences and metadata: UniProt Consortium, CC BY 4.0.
Domain matches
No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.
Snapshot counters
- proteins
- 4,843
- matches
- 4,910
- proteomes
- 2,798
- taxa
- 7,363
- structures
- 15
- alphafold models
- 619
- domain architectures
- 128
Classification basis
pfam previous unknown name
No scoring reasons supplied.
Related Mech records
This family joined the worklist after the frozen cross-Mech scan, so other Mechs were not searched for it. Missing links here are not evidence that other Mechs lack it; rows shown come from mentions of a former DUF/UPF name.
No cross-Mech examples are present in the supplied snapshot.
Curation history and reviews
No retained curation events supplied.
No retained review supplied.
Record source
Status and evidence
- Seed status
- A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
- Characterization
- A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
- Evidence counts
- Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
- Curation status
- Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
- Missing counts
- Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.