DUFMech

All families / PF12398

PF12398: DUF3660

Receptor serine/threonine kinase

Curation status
SEEDED
Seed status
KNOWN HISTORICAL DUF
Characterization
UNSCORED

Grounding

PF12398: Receptor serine/threonine kinase
IPR022126: integrated entry for Receptor serine/threonine kinase

Source description

This domain family is found in eukaryotes, and is approximately 40 amino acids in length. The family is found in association with PF00954 (Pfam entry), PF01453 (Pfam entry), PF00069 (Pfam entry), PF08276 (Pfam entry). There is a conserved ELPL sequence motif.

Evidence and references

Source descriptions and links are provenance, not independent functional validation.

Evidence counts: not scored.

Curated functional assertions

No curated functional assertions supplied.

Protein sequence examples

3 verified sequence examples. FASTA

UniProtProtein / organismSequenceProvenance
P0DH86G-type lectin S-receptor-like serine/threonine-protein kinase SRK
Arabidopsis thaliana		853 aa; version 1
UniProt 2026_03		UNIPROT FETCH
1 sibling references
Q39086Receptor-like serine/threonine-protein kinase SD1-7
Arabidopsis thaliana		843 aa; version 1
UniProt 2026_03		UNIPROT FETCH
1 sibling references
Q9S972Receptor-like serine/threonine-protein kinase SD1-6
Arabidopsis thaliana		847 aa; version 2
UniProt 2026_03		UNIPROT FETCH
2 sibling references

Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.

Sequences and metadata: UniProt Consortium, CC BY 4.0.

Domain matches

No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.

Snapshot counters

proteins
672
matches
684
proteomes
196
taxa
551
structures
0
alphafold models
520
domain architectures
68

Classification basis

short name matches duf

No scoring reasons supplied.

Related Mech records

FamilyMechRecordProteinLink basis
DUF3660 (PF12398)ProteinTraitsMechS-locus, receptor kinase
trait identifier
DUF3660 (PF12398)ProteinTraitsMechDomain of unknown function (DUF3403)Q9S972
Receptor-like serine/threonine-protein kinase SD1-6		canonical example family classification
DUF3660 (PF12398)ProteinTraitsMechReceptor serine/threonine kinaseP0DH86
G-type lectin S-receptor-like serine/threonine-protein kinase SRK		canonical example family classification
DUF3660 (PF12398)ProteinTraitsMechReceptor serine/threonine kinaseQ39086
Receptor-like serine/threonine-protein kinase SD1-7		canonical example family classification
DUF3660 (PF12398)ProteinTraitsMechReceptor serine/threonine kinaseQ9S972
Receptor-like serine/threonine-protein kinase SD1-6		canonical example family classification
DUF3660 (PF12398)ProteinTraitsMechReceptor serine/threonine kinase
trait identifier

Curation history and reviews

No retained curation events supplied.

No retained review supplied.

Record source

data/families/PF12398.yaml
Family YAML in this build

Download this family (JSON)

Status and evidence

Seed status
A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
Characterization
A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
Evidence counts
Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
Curation status
Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
Missing counts
Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.