All families / PF12480
PF12480: GARIL_Rab2_bd
Golgi associated RAB2 interactor protein-like, Rab2B-binding domain
- Curation status
- SEEDED
- Seed status
- EX DUF
- Characterization
- UNSCORED
Grounding
PF12480: Golgi associated RAB2 interactor protein-like, Rab2B-binding domain
IPR022168: integrated entry for Golgi associated RAB2 interactor protein-like, Rab2B-binding domain
Source description
This domain is found in Golgi associated RAB2 interactor proteins and it is likely a Rab2B-binding domain [InterPro reference PUB00100833,InterPro reference PUB00100832,InterPro reference PUB00100834]. Some members included in this entry, such as GAR1A/B and GAR2, are RAB2B effector proteins required for accurate acrosome formation and normal male fertility [InterPro reference PUB00100833,InterPro reference PUB00100834]. GARI-L4 is a RAB2B effector protein required for the compacted Golgi morphology [InterPro reference PUB00100832]. GARIL5 is a Rab2B effector protein which promotes cytosolic DNA-induced innate immune responses [InterPro reference PUB00100835].
Evidence and references
- InterPro entry and its literature references. PUB identifiers are internal InterPro references, not PubMed identifiers. Unresolved citations link to the originating entry.
- Frozen description source: InterPro/Pfam API
Source descriptions and links are provenance, not independent functional validation.
Evidence counts: not scored.
Curated functional assertions
No curated functional assertions supplied.
Protein sequence examples
11 verified sequence examples. FASTA
| UniProt | Protein / organism | Sequence | Provenance |
|---|---|---|---|
| A1L3C1 | Golgi-associated RAB2 interactor protein 5A Mus musculus | 212 aa; version 2 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| D3YV92 | Golgi-associated RAB2 interactor protein 2 Mus musculus | 440 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| Q3UZD7 | Golgi-associated RAB2 interactor protein 1B Mus musculus | 341 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| Q5DTT3 | Protein TASOR 2 Mus musculus | 2382 aa; version 2 UniProt 2026_03 | UNIPROT FETCH |
| Q5STT6 | Golgi-associated RAB2B interactor protein 3 Mus musculus | 665 aa; version 3 UniProt 2026_03 | UNIPROT FETCH2 sibling references |
| Q5VWN6 | Protein TASOR 2 Homo sapiens | 2430 aa; version 1 UniProt 2026_03 | PTM REGISTRY MIRROR9 sibling references |
| Q6IPT2 | Golgi-associated RAB2 interactor protein 5A Homo sapiens | 247 aa; version 2 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| Q8IYT1 | Golgi-associated RAB2 interactor protein 4 Homo sapiens | 594 aa; version 2 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| Q8NEG0 | Golgi-associated RAB2 interactor protein 6 Homo sapiens | 241 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| Q8TC56 | Golgi-associated RAB2 interactor protein 3 Homo sapiens | 605 aa; version 2 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
First 10 shown; the FASTA and family JSON contain all examples.
Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.
Sequences and metadata: UniProt Consortium, CC BY 4.0.
Domain matches
No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.
Snapshot counters
- proteins
- 2,442
- matches
- 2,570
- proteomes
- 325
- taxa
- 1,056
- structures
- 0
- alphafold models
- 1,670
- domain architectures
- 34
Classification basis
pfam previous unknown name
No scoring reasons supplied.
Related Mech records
This family joined the worklist after the frozen cross-Mech scan, so other Mechs were not searched for it. Missing links here are not evidence that other Mechs lack it; rows shown come from mentions of a former DUF/UPF name.
No cross-Mech examples are present in the supplied snapshot.
Curation history and reviews
No retained curation events supplied.
No retained review supplied.
Record source
Status and evidence
- Seed status
- A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
- Characterization
- A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
- Evidence counts
- Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
- Curation status
- Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
- Missing counts
- Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.