All families / PF14251
PF14251: PterinBD-DUF4346
PterinBD-DUF4346
- Curation status
- SEEDED
- Seed status
- KNOWN HISTORICAL DUF
- Characterization
- UNSCORED
Grounding
PF14251: PterinBD-DUF4346
IPR025595: integrated entry for PterinBD-DUF4346
Source description
This domain is found in bacteria, archaea and a few lower eukaryotes species. There are two conserved sequence motifs: LDP and DHA. Many members of this family have been annotated as dihydropteroate synthases, however no experimental evidence can be found for this and Q57571 (UniProtKB protein) has been shown not to possess dihydropteroate synthase activity [InterPro reference PUB00057368]. In bacteria, this domain is found in predicted conflict systems that also encode genes for an active Thymidylate synthase and a pterin-dependent one-carbon carrier (MtrA domain). This system is predicted to deplete virally generated nucleotides and replace them with a nucleotide that restricts invasive DNA or protects host DNA [InterPro reference PUB00155486].
Evidence and references
- InterPro entry and its literature references. PUB identifiers are internal InterPro references, not PubMed identifiers. Unresolved citations link to the originating entry.
- Frozen description source: InterPro/Pfam API
Source descriptions and links are provenance, not independent functional validation.
Evidence counts: not scored.
Curated functional assertions
No curated functional assertions supplied.
Protein sequence examples
1 verified sequence example. FASTA
| UniProt | Protein / organism | Sequence | Provenance |
|---|---|---|---|
| Q57571 | Uncharacterized protein MJ0107 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) | 525 aa; version 1 UniProt 2026_03 | PTM REGISTRY MIRROR11 sibling references
|
Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.
Sequences and metadata: UniProt Consortium, CC BY 4.0.
Domain matches
No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.
Snapshot counters
- proteins
- 775
- matches
- 781
- proteomes
- 668
- taxa
- 1,712
- structures
- 0
- alphafold models
- 574
- domain architectures
- 16
Classification basis
short name matches duf
No scoring reasons supplied.
Related Mech records
| Family | Mech | Record | Protein | Link basis |
|---|---|---|---|---|
| PterinBD-DUF4346 (PF14251) | ProteinTraitsMech | dihydroneopterin aldolase activity | Q57571 Uncharacterized protein MJ0107 | canonical example family classification |
| PterinBD-DUF4346 (PF14251) | ProteinTraitsMech | dihydropteroate synthase-like protein | Q57571 Uncharacterized protein MJ0107 | canonical example family classification |
| PterinBD-DUF4346 (PF14251) | ProteinTraitsMech | Pterin_binding | Q57571 Uncharacterized protein MJ0107 | canonical example family classification |
| PterinBD-DUF4346 (PF14251) | ProteinTraitsMech | Domain of unknown function DUF6513 | Q57571 Uncharacterized protein MJ0107 | canonical example family classification |
| PterinBD-DUF4346 (PF14251) | ProteinTraitsMech | Pterin-binding domain | Q57571 Uncharacterized protein MJ0107 | canonical example family classification |
| PterinBD-DUF4346 (PF14251) | ProteinTraitsMech | Ycf91-like | Q57571 Uncharacterized protein MJ0107 | canonical example family classification |
| PterinBD-DUF4346 (PF14251) | ProteinTraitsMech | Ycf91-like | trait identifier | |
| PterinBD-DUF4346 (PF14251) | ProteinTraitsMech | Pterin binding enzyme | Q57571 Uncharacterized protein MJ0107 | canonical example family classification |
| PterinBD-DUF4346 (PF14251) | ProteinTraitsMech | PterinBD-DUF4346 | Q57571 Uncharacterized protein MJ0107 | canonical example family classification |
| PterinBD-DUF4346 (PF14251) | ProteinTraitsMech | PterinBD-DUF4346 | trait identifier | |
| PterinBD-DUF4346 (PF14251) | ProteinTraitsMech | Family of unknown function (DUF6513) | Q57571 Uncharacterized protein MJ0107 | canonical example family classification |
| PterinBD-DUF4346 (PF14251) | ProteinTraitsMech | Pterin-binding domain profile | Q57571 Uncharacterized protein MJ0107 | canonical example family classification |
Curation history and reviews
No retained curation events supplied.
No retained review supplied.
Record source
Status and evidence
- Seed status
- A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
- Characterization
- A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
- Evidence counts
- Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
- Curation status
- Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
- Missing counts
- Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.