All families / PF15232
PF15232: DUF4585
Domain of unknown function (DUF4585)
- Curation status
- SEEDED
- Seed status
- UNKNOWN CANDIDATE
- Characterization
- UNSCORED
Grounding
PF15232: Domain of unknown function (DUF4585)
IPR027838: integrated entry for Domain of unknown function (DUF4585)
Source description
The function of this protein domain family is yet to be characterised. It is putatively thought to lie in the C-terminal domain of the DNA nucleotide repair protein, Xeroderma pigmentosa complementation group A (XPA). The function of XPA is to bind to DNA and repair any mismatched base pairs. This domain family is often found in eukaryotes, and is approximately 70 amino acids in length. There is a conserved DPE sequence motif. In humans, this protein is encoded for in the chromosomal position, Chromosome 5 open reading frame 65. Mutations in the gene lead to myelodysplastic syndromes, where there is inefficient stem cell production in the bone marrow. This suggests that the protein may have a role in forming blood cells [InterPro reference PUB00067380].
Evidence and references
- InterPro entry and its literature references. PUB identifiers are internal InterPro references, not PubMed identifiers. Unresolved citations link to the originating entry.
- Frozen description source: InterPro/Pfam API
Source descriptions and links are provenance, not independent functional validation.
Evidence counts: not scored.
Curated functional assertions
No curated functional assertions supplied.
Protein sequence examples
5 verified sequence examples. FASTA
| UniProt | Protein / organism | Sequence | Provenance |
|---|---|---|---|
| D3Z1D3 | Cardiac-enriched FHL2-interacting protein Mus musculus | 1412 aa; version 1 UniProt 2026_03 | UNIPROT FETCH2 sibling references |
| D6RIA3 | Uncharacterized protein C4orf54 Homo sapiens | 1793 aa; version 1 UniProt 2026_03 | PTM REGISTRY MIRROR |
| E0CYV9 | Uncharacterized protein C4orf54 homolog Mus musculus | 1786 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| E7EW31 | Proline-rich basic protein 1 Homo sapiens | 1015 aa; version 2 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| Q711Q0 | Cardiac-enriched FHL2-interacting protein Homo sapiens | 1435 aa; version 2 UniProt 2026_03 | UNIPROT FETCH2 sibling references |
Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.
Sequences and metadata: UniProt Consortium, CC BY 4.0.
Domain matches
No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.
Snapshot counters
- proteins
- 1,772
- matches
- 1,772
- proteomes
- 702
- taxa
- 2,139
- structures
- 0
- alphafold models
- 455
- domain architectures
- 10
Classification basis
short name matches duf; name says unknown function; domain of unknown function
No scoring reasons supplied.
Related Mech records
| Family | Mech | Record | Protein | Link basis |
|---|---|---|---|---|
| DUF4585 (PF15232) | ProteinTraitsMech | Domain of unknown function DUF4585 | D3Z1D3 Cardiac-enriched FHL2-interacting protein | canonical example family classification |
| DUF4585 (PF15232) | ProteinTraitsMech | Domain of unknown function DUF4585 | D6RIA3 Uncharacterized protein C4orf54 | canonical example family classification |
| DUF4585 (PF15232) | ProteinTraitsMech | Domain of unknown function DUF4585 | E0CYV9 Uncharacterized protein C4orf54 homolog | canonical example family classification |
| DUF4585 (PF15232) | ProteinTraitsMech | Domain of unknown function DUF4585 | E7EW31 Proline-rich basic protein 1 | canonical example family classification |
| DUF4585 (PF15232) | ProteinTraitsMech | Domain of unknown function DUF4585 | Q711Q0 Cardiac-enriched FHL2-interacting protein | canonical example family classification |
| DUF4585 (PF15232) | ProteinTraitsMech | Domain of unknown function DUF4585 | trait identifier | |
| DUF4585 (PF15232) | ProteinTraitsMech | Domain of unknown function (DUF4585) | D3Z1D3 Cardiac-enriched FHL2-interacting protein | canonical example family classification |
| DUF4585 (PF15232) | ProteinTraitsMech | Domain of unknown function (DUF4585) | D6RIA3 Uncharacterized protein C4orf54 | canonical example family classification |
| DUF4585 (PF15232) | ProteinTraitsMech | Domain of unknown function (DUF4585) | Q711Q0 Cardiac-enriched FHL2-interacting protein | canonical example family classification |
| DUF4585 (PF15232) | ProteinTraitsMech | Domain of unknown function (DUF4585) | trait identifier |
Curation history and reviews
No retained curation events supplied.
No retained review supplied.
Record source
Status and evidence
- Seed status
- A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
- Characterization
- A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
- Evidence counts
- Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
- Curation status
- Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
- Missing counts
- Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.