DUFMech

All families / PF25752

PF25752: DUF1619_N

N-terminal domain of DUF1619

Curation status
SEEDED
Seed status
KNOWN HISTORICAL DUF
Characterization
UNSCORED

Grounding

PF25752: N-terminal domain of DUF1619
IPR057724: integrated entry for N-terminal domain of DUF1619

Source description

This is domain is found N-terminal in tectonic proteins (TCTN1/2/3) It contains a number of conserved cysteine residues predicted to form disulfide bonds. Although function of this domain is currently unknown, studies on TCTN2 suggest that it is indispensable for its functions [InterPro reference PUB00097826,InterPro reference PUB00097827]. TCTN1, TCTN2, and TCTN3 are members of the tectonic protein family that play crucial roles in ciliogenesis and ciliary function. While they share some common functions, each protein also has specific roles in the process of cilia formation and maintenance. These proteins interact with several other ciliopathy proteins, forming a complex known as the Tectonic ciliopathy complex. This complex is required for hedgehog signalling transduction and regulation of ciliary membrane composition [InterPro reference PUB00069722,InterPro reference PUB00160606].

Evidence and references

Source descriptions and links are provenance, not independent functional validation.

Evidence counts: not scored.

Curated functional assertions

No curated functional assertions supplied.

Protein sequence examples

7 verified sequence examples. FASTA

UniProtProtein / organismSequenceProvenance
Q2MV57Tectonic-2
Mus musculus
700 aa; version 2
UniProt 2026_03
UNIPROT FETCH
3 sibling references
Q2MV58Tectonic-1
Homo sapiens
587 aa; version 2
UniProt 2026_03
UNIPROT FETCH
4 sibling references
Q6NUS6Tectonic-3
Homo sapiens
607 aa; version 2
UniProt 2026_03
UNIPROT FETCH
4 sibling references
Q8BZ64Tectonic-1
Mus musculus
593 aa; version 1
UniProt 2026_03
PTM REGISTRY MIRROR
7 sibling references
Q8R2Q6Tectonic-3
Mus musculus
595 aa; version 1
UniProt 2026_03
UNIPROT FETCH
3 sibling references
Q96GX1Tectonic-2
Homo sapiens
697 aa; version 1
UniProt 2026_03
UNIPROT FETCH
4 sibling references
Q9VMH0Tectonic
Drosophila melanogaster
657 aa; version 4
UniProt 2026_03
UNIPROT FETCH
4 sibling references

Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.

Sequences and metadata: UniProt Consortium, CC BY 4.0.

Domain matches

No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.

Snapshot counters

proteins
3,088
matches
3,095
proteomes
1,178
taxa
3,947
structures
0
alphafold models
2,636
domain architectures
41

Classification basis

name matches duf

No scoring reasons supplied.

Related Mech records

FamilyMechRecordProteinLink basis
DUF1619_N (PF25752)ProteinTraitsMechcentral nervous system interneuron axonogenesisQ8BZ64
Tectonic-1
canonical example family classification
DUF1619_N (PF25752)ProteinTraitsMechsomatic motor neuron differentiationQ8BZ64
Tectonic-1
canonical example family classification
DUF1619_N (PF25752)ProteinTraitsMechY-shaped link assemblyQ9VMH0
Tectonic
canonical example family classification
DUF1619_N (PF25752)ProteinTraitsMechTectonic-1-3 domainQ2MV57
Tectonic-2
canonical example family classification
DUF1619_N (PF25752)ProteinTraitsMechTectonic-1-3 domainQ2MV58
Tectonic-1
canonical example family classification
DUF1619_N (PF25752)ProteinTraitsMechTectonic-1-3 domainQ6NUS6
Tectonic-3
canonical example family classification
DUF1619_N (PF25752)ProteinTraitsMechTectonic-1-3 domainQ8BZ64
Tectonic-1
canonical example family classification
DUF1619_N (PF25752)ProteinTraitsMechTectonic-1-3 domainQ8R2Q6
Tectonic-3
canonical example family classification
DUF1619_N (PF25752)ProteinTraitsMechTectonic-1-3 domainQ96GX1
Tectonic-2
canonical example family classification
DUF1619_N (PF25752)ProteinTraitsMechTectonic-1-3 domainQ9VMH0
Tectonic
canonical example family classification
DUF1619_N (PF25752)ProteinTraitsMechTectonic-1-3, N-terminal domainQ2MV57
Tectonic-2
canonical example family classification
DUF1619_N (PF25752)ProteinTraitsMechTectonic-1-3, N-terminal domainQ2MV58
Tectonic-1
canonical example family classification
DUF1619_N (PF25752)ProteinTraitsMechTectonic-1-3, N-terminal domainQ6NUS6
Tectonic-3
canonical example family classification
DUF1619_N (PF25752)ProteinTraitsMechTectonic-1-3, N-terminal domainQ8BZ64
Tectonic-1
canonical example family classification
DUF1619_N (PF25752)ProteinTraitsMechTectonic-1-3, N-terminal domainQ8R2Q6
Tectonic-3
canonical example family classification
DUF1619_N (PF25752)ProteinTraitsMechTectonic-1-3, N-terminal domainQ96GX1
Tectonic-2
canonical example family classification
DUF1619_N (PF25752)ProteinTraitsMechTectonic-1-3, N-terminal domainQ9VMH0
Tectonic
canonical example family classification
DUF1619_N (PF25752)ProteinTraitsMechTectonic-1-3, N-terminal domain
trait identifier
DUF1619_N (PF25752)ProteinTraitsMechN-terminal domain of DUF1619Q2MV58
Tectonic-1
canonical example family classification
DUF1619_N (PF25752)ProteinTraitsMechN-terminal domain of DUF1619Q6NUS6
Tectonic-3
canonical example family classification
DUF1619_N (PF25752)ProteinTraitsMechN-terminal domain of DUF1619Q96GX1
Tectonic-2
canonical example family classification
DUF1619_N (PF25752)ProteinTraitsMechN-terminal domain of DUF1619
trait identifier
DUF1619_N (PF25752)ProteinTraitsMechTectonic domain of DUF1619Q2MV57
Tectonic-2
canonical example family classification
DUF1619_N (PF25752)ProteinTraitsMechTectonic domain of DUF1619Q2MV58
Tectonic-1
canonical example family classification
DUF1619_N (PF25752)ProteinTraitsMechTectonic domain of DUF1619Q6NUS6
Tectonic-3
canonical example family classification
DUF1619_N (PF25752)ProteinTraitsMechTectonic domain of DUF1619Q8BZ64
Tectonic-1
canonical example family classification
DUF1619_N (PF25752)ProteinTraitsMechTectonic domain of DUF1619Q8R2Q6
Tectonic-3
canonical example family classification
DUF1619_N (PF25752)ProteinTraitsMechTectonic domain of DUF1619Q96GX1
Tectonic-2
canonical example family classification
DUF1619_N (PF25752)ProteinTraitsMechTectonic domain of DUF1619Q9VMH0
Tectonic
canonical example family classification

Curation history and reviews

No retained curation events supplied.

No retained review supplied.

Record source

data/families/PF25752.yaml
Family YAML in this build

Download this family (JSON)

Status and evidence

Seed status
A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
Characterization
A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
Evidence counts
Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
Curation status
Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
Missing counts
Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.