Aditi system

traitmech:000247 · CLASS · PROPOSED

A phage defense system in which an organism possesses a two-component Aditi locus represented by DitA and DitB profiles that can protect bacteria from bacteriophage infection.

Trait evidence (6)

DOI:10.1016/j.chom.2022.09.017
discovery of 21 defense systems that protect bacteria from phages, based on computational genomic analyses and phage-infection experiments

Millman et al. report the computational and experimental cohort that DefenseFinder cites for Aditi as a bacterial anti-phage system.
DOI:10.1101/2022.05.11.491447
discovery of 21 new defense systems that protect bacteria from phages, based on computational genomic analyses and phage infection experiments

The bioRxiv version of Millman et al. independently carries the 21-system discovery claim linked from DefenseFinder's Aditi article registry.
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md
Aditi | 10\.1101/2022\.05\.11\.491447 | An expanding arsenal of immune systems that protect bacteria from phages

The DefenseFinder model registry maps the named Aditi system to the Millman et al. antiphage-system discovery preprint.
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/DefenseFinder_rules.tsv
Aditi__DitA, Aditi__DitB

The DefenseFinder rules table models Aditi as a system with DitA and DitB mandatory profiles.
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md
Aditi__DitA | Aditi__DitA | Aditi

The DefenseFinder HMM inventory records DitA as an Aditi profile.
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md
Aditi__DitB | Aditi__DitB | Aditi

The DefenseFinder HMM inventory records DitB as an Aditi profile.

Aditi loci confer bacterial phage defense

Conservative system-level sketch linking possession of an Aditi locus to restricted bacteriophage propagation without asserting the unresolved phage trigger or molecular output.

NONMECHANISTIC · The graph captures Aditi as a named anti-phage system with DitA and DitB DefenseFinder profiles while leaving its phage trigger, molecular substrate, antiviral effector output, and subtype breadth unresolved.

Edge evidence

Aditi locus contributes to restricted phage propagation RO:0002326
DefenseFinder maps Aditi to a bacterial anti-phage-system discovery preprint and represents Aditi loci through DitA and DitB component profiles.
- DOI:10.1016/j.chom.2022.09.017 discovery of 21 defense systems that protect bacteria from phages Millman et al. describe the anti-phage discovery cohort that the DefenseFinder Aditi registry row maps to the Aditi system.
- https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md Aditi | 10\.1101/2022\.05\.11\.491447 | An expanding arsenal of immune systems that protect bacteria from phages The DefenseFinder registry maps Aditi itself to the Millman et al. bacterial antiphage-system discovery preprint.
- https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/DefenseFinder_rules.tsv Aditi__DitA, Aditi__DitB The DefenseFinder rules table supports DitA and DitB as the mandatory Aditi system profiles.
restricted phage propagation confers Aditi system METPO:2007700
Aditi-mediated phage restriction realizes the Aditi system trait.
- DOI:10.1016/j.chom.2022.09.017 discovery of 21 defense systems that protect bacteria from phages Millman et al. place the Aditi discovery cohort in the set of bacterial systems that protect against phages.
- https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md Aditi | 10\.1101/2022\.05\.11\.491447 | An expanding arsenal of immune systems that protect bacteria from phages DefenseFinder records Aditi as a named system from the Millman et al. antiphage discovery preprint.
Aditi system is a phage defense system rdfs:subClassOf
Aditi system possession is a phage-defense-system trait.
- https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md An expanding arsenal of immune systems that protect bacteria from phages DefenseFinder associates Aditi with the Millman et al. bacterial antiphage-system discovery paper.

Provenance

Identifier source: TraitMech local identifier
Definition source: DOI:10.1016/j.chom.2022.09.017

Parent traits (1)

phage defense system traitmech:000209

Synonyms (1)

Aditi EXACT_SYNONYM · https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md

kg-microbe context

No kg-microbe node embedding matched this record in the 2026-04-25 deepwalk.

Discussions and Knowledge Gaps (1)

Open questions attached to this trait. Seeded by just knowledge-gap-scan and curated; see the corpus-wide index.

Resolve Aditi phage triggers and effector outputs before minting narrower Aditi mechanism children.

KNOWLEDGE GAP OPEN aditi-mechanism-gap · raised by codex · 2026-09-18

Attached to causal_graphs#aditi_locus_restricts_phage

Millman et al. and DefenseFinder support Aditi as a named anti-phage system with DitA and DitB profiles, but the trigger, molecular substrate, antiviral effector output, and subtype-specific mechanism are not resolved enough here to assert a narrower mechanistic child trait.

Curation history

2026-09-18T18:47:25Z · MINTED_TRAITMECH_ID · codex
Minted Aditi system as a DOI-backed GENOMICS TraitRecord under phage defense system after an ignored-and-hidden duplicate review found no exact live TraitMech, METPO, or prior proposal record; the replacement placeholder is reserved in proposals/metpo_traitmech_v124.