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Aristaios system

traitmech:000313 · CLASS · PROPOSED

A phage defense system in which an organism possesses an Aristaios locus that can restrict bacteriophage infection.

Trait evidence (3)

  • DOI:10.1093/nar/gkae671
    These systems were named after cheese, cattle or fermentation related deities (Rhea, Aristaios, Kamadhenu, Fliodhais, Audmula, Rugutis and Hesat)

    Grafakou et al. named Aristaios among seven not previously described lactococcal antiphage systems.

  • DOI:10.1128/aem.01120-24
    Recently, three plasmid-encoded lactococcal antiphage systems, named Rhea, Aristaios, and Kamadhenu, were discovered. These systems were found to confer high levels of resistance against various Skunavirus members.

    Grafakou et al. later characterized Aristaios as one of three plasmid-encoded lactococcal antiphage systems conferring strong resistance against Skunavirus members.

  • https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md
    Aristaios | 10\.1093/nar/gkae671 | Discovery of antiphage systems in the lactococcal plasmidome

    The DefenseFinder article registry maps the named Aristaios system to the Grafakou et al. lactococcal antiphage-system discovery paper.

Aristaios loci confer bacterial phage defense

Conservative system-level sketch linking possession of an Aristaios locus to restricted bacteriophage propagation without asserting the unresolved phage trigger or molecular output.

NONMECHANISTIC · The graph captures Aristaios as a named lactococcal anti-phage system while leaving its direct phage trigger, molecular substrate, antiviral effector output, natural locus breadth, and the absence of pinned DefenseFinder HMM or rule rows unresolved.

Aristaios loci confer bacterial phage defense Interactive directed graph showing evidence-backed causal relationships for Aristaios system.

Edge evidence

  • Aristaios locus contributes to restricted phage propagation RO:0002326

    The lactococcal plasmidome screen discovered Aristaios as a named antiphage system, and the DefenseFinder article registry maps the Aristaios system to that discovery paper.

    • DOI:10.1093/nar/gkae671 These systems were named after cheese, cattle or fermentation related deities (Rhea, Aristaios, Kamadhenu, Fliodhais, Audmula, Rugutis and Hesat) Grafakou et al. named Aristaios as one of the novel lactococcal antiphage systems.
    • DOI:10.1128/aem.01120-24 Recently, three plasmid-encoded lactococcal antiphage systems, named Rhea, Aristaios, and Kamadhenu, were discovered. These systems were found to confer high levels of resistance against various Skunavirus members. Grafakou et al. later characterized Aristaios as one of three plasmid-encoded lactococcal antiphage systems conferring strong resistance against Skunavirus members.
    • https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md Aristaios | 10\.1093/nar/gkae671 | Discovery of antiphage systems in the lactococcal plasmidome The DefenseFinder article registry maps the named Aristaios system to the Grafakou et al. lactococcal antiphage-system discovery paper.
  • restricted phage propagation confers Aristaios system METPO:2007700

    Aristaios-mediated phage restriction realizes the Aristaios system trait.

    • DOI:10.1093/nar/gkae671 These systems were named after cheese, cattle or fermentation related deities (Rhea, Aristaios, Kamadhenu, Fliodhais, Audmula, Rugutis and Hesat) Grafakou et al. named Aristaios as one of the novel lactococcal antiphage systems.
    • DOI:10.1128/aem.01120-24 Recently, three plasmid-encoded lactococcal antiphage systems, named Rhea, Aristaios, and Kamadhenu, were discovered. These systems were found to confer high levels of resistance against various Skunavirus members. Grafakou et al. later characterized Aristaios as one of three plasmid-encoded lactococcal antiphage systems conferring strong resistance against Skunavirus members.
  • Aristaios system is a phage defense system rdfs:subClassOf

    Aristaios system possession is a phage-defense-system trait.

Provenance

Identifier source
TraitMech local identifier
Definition source
DOI:10.1093/nar/gkae671

Parent traits (1)

Synonyms (1)

  • Aristaios EXACT_SYNONYM · DOI:10.1093/nar/gkae671

kg-microbe context

No kg-microbe node embedding matched this record in the 2026-04-25 deepwalk.

Discussions and Knowledge Gaps (1)

Open questions attached to this trait. Seeded by just knowledge-gap-scan and curated; see the corpus-wide index.

Resolve Aristaios phage triggers and effector outputs before minting narrower Aristaios mechanism children.

KNOWLEDGE GAP OPEN aristaios-mechanism-gap · raised by codex · 2026-09-20

Attached to causal_graphs#aristaios_locus_restricts_phage

Grafakou et al. and DefenseFinder support Aristaios as a named anti-phage system, but the direct trigger, molecular substrate, antiviral effector output, natural locus breadth, and profile-to-component model are not resolved enough here to assert a narrower mechanistic child trait.

Curation history

  1. · MINTED_TRAITMECH_ID · codex

    Minted Aristaios system as a DOI-backed GENOMICS TraitRecord under phage defense system after an ignored-and-hidden duplicate review found no exact live TraitMech, METPO, history, or prior proposal record; the replacement placeholder is reserved in proposals/metpo_traitmech_v190.