Avs V system

traitmech:000538 · CLASS · PROPOSED

An AVAST system in which an organism possesses a genome-encoded subtype V locus represented by DefenseFinder with an Avs5A profile.

Trait evidence (6)

DOI:10.1126/science.aba0372
AVAST, antiviral ATPase/NTPase of the STAND superfamily

Gao et al. coined AVAST as an antiviral STAND ATPase/NTPase defense-system family.
DOI:10.1016/j.molcel.2026.01.004
AVAST type 5 (Avs5) systems, part of the signal transduction ATPases of numerous domains (STAND) superfamily, confer conserved immunity against jumbo phages

Muralidharan et al. support treating Avs5 systems as type V AVAST systems with conserved immunity against jumbo phages.
DOI:10.1016/j.molcel.2026.01.004
Recognition of phage infection triggers the Sir2-like effector domain of Avs5 across three Avs5 clades

Muralidharan et al. connect Avs5 phage recognition to Sir2-like effector activation.
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md
| Avs | 10\.1126/science\.aba0372 | Diverse enzymatic activities mediate antiviral immunity in prokaryotes |

The pinned DefenseFinder article registry maps the Avs source key to the Gao et al. pangenome-scale antiviral-immunity paper.
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md
| Avs_V__Avs5A | Avs_V__Avs5A | Avs_V | Custom | 60 |

The pinned DefenseFinder HMM inventory records Avs_V__Avs5A under the Avs_V model namespace.
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/DefenseFinder_rules.tsv
Avs Avs_V 1 1 Avs_V__Avs5A

The pinned DefenseFinder rules table models Avs_V as an Avs subsystem with an Avs5A profile.

Avs V loci support Sir2-like effector activation

Conservative system-level sketch linking an Avs_V locus to Avs5 Sir2-like effector activation and Avs V system possession.

NONMECHANISTIC · The graph captures Avs_V at locus and Avs5 Sir2-like effector-activation level without asserting the exact Avs5A component role, JADA trigger-protein breadth, native host breadth, sensitive jumbo-phage breadth, or whether every DefenseFinder Avs_V prediction is a complete experimentally active Avs V locus.

Edge evidence

Avs V locus contributes to Avs5 Sir2-like effector activation RO:0002326
Avs V loci encode Avs5 components, and Avs5 phage-infection recognition triggers a Sir2-like effector domain.
- DOI:10.1016/j.molcel.2026.01.004 Recognition of phage infection triggers the Sir2-like effector domain of Avs5 across three Avs5 clades Muralidharan et al. connect Avs5 phage recognition to Sir2-like effector activation.
- https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md | Avs_V__Avs5A | Avs_V__Avs5A | Avs_V | Custom | 60 | The pinned DefenseFinder HMM inventory records Avs_V__Avs5A under the Avs_V model namespace.
Avs5 Sir2-like effector activation confers Avs V system METPO:2007700
The first-pass Avs V system trait is realized by Avs5 phage recognition, Sir2-like effector activation, and conserved immunity against jumbo phages.
- DOI:10.1016/j.molcel.2026.01.004 AVAST type 5 (Avs5) systems, part of the signal transduction ATPases of numerous domains (STAND) superfamily, confer conserved immunity against jumbo phages Muralidharan et al. support treating Avs5 systems as type V AVAST systems with conserved immunity against jumbo phages.
- DOI:10.1016/j.molcel.2026.01.004 Recognition of phage infection triggers the Sir2-like effector domain of Avs5 across three Avs5 clades Muralidharan et al. connect Avs5 phage recognition to Sir2-like effector activation.
- https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/DefenseFinder_rules.tsv Avs Avs_V 1 1 Avs_V__Avs5A The pinned DefenseFinder rules table models Avs_V as an Avs subsystem with an Avs5A profile.
Avs V system is a AVAST system rdfs:subClassOf
Avs V system possession is an AVAST-system trait.
- DOI:10.1126/science.aba0372 AVAST, antiviral ATPase/NTPase of the STAND superfamily Gao et al. coined AVAST as an antiviral STAND ATPase/NTPase defense-system family.
- DOI:10.1016/j.molcel.2026.01.004 AVAST type 5 (Avs5) systems, part of the signal transduction ATPases of numerous domains (STAND) superfamily, confer conserved immunity against jumbo phages Muralidharan et al. support treating Avs5 systems as type V AVAST systems with conserved immunity against jumbo phages.
- https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/DefenseFinder_rules.tsv Avs Avs_V 1 1 Avs_V__Avs5A The pinned DefenseFinder rules table models Avs_V as an Avs subsystem with an Avs5A profile.

Provenance

Identifier source: TraitMech local identifier
Definition source: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/DefenseFinder_rules.tsv

Parent traits (1)

AVAST system traitmech:000239

Synonyms (2)

Avs_V RELATED_SYNONYM · https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/DefenseFinder_rules.tsv
Avs_V__Avs5A RELATED_SYNONYM · https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md

kg-microbe context

No kg-microbe node embedding matched this record in the 2026-04-25 deepwalk.

Discussions and Knowledge Gaps (1)

Open questions attached to this trait. Seeded by just knowledge-gap-scan and curated; see the corpus-wide index.

Resolve the Avs5A component role, exact JADA trigger breadth, native host breadth, sensitive jumbo-phage breadth, and DefenseFinder profile-to-activity requirements before minting Avs V mechanism or component children.

KNOWLEDGE GAP OPEN avs-v-component-and-host-gap · raised by codex · 2026-10-02

Attached to causal_graphs#avs_v_locus_sir2_effector_activation

Muralidharan et al. support Avs5 Sir2-like effector activation during jumbo-phage defense, and the pinned DefenseFinder HMM inventory and rules table support Avs_V as a subtype V model with an Avs5A profile. This first-pass record leaves the exact component role, JADA trigger breadth, native host breadth, sensitive jumbo-phage breadth, and profile-to-activity requirements unresolved.

Evidence

DOI:10.1016/j.molcel.2026.01.004
AVAST type 5 (Avs5) systems, part of the signal transduction ATPases of numerous domains (STAND) superfamily, confer conserved immunity against jumbo phages
DOI:10.1016/j.molcel.2026.01.004
Recognition of phage infection triggers the Sir2-like effector domain of Avs5 across three Avs5 clades
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md
| Avs_V__Avs5A | Avs_V__Avs5A | Avs_V | Custom | 60 |
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/DefenseFinder_rules.tsv
Avs Avs_V 1 1 Avs_V__Avs5A

Curation history

2026-10-02T07:21:42Z · MINTED_TRAITMECH_ID · codex
Minted Avs V system as a DOI- and DefenseFinder-backed GENOMICS TraitRecord under the AVAST system parent after an ignored-and-hidden duplicate review found no exact live TraitMech, METPO, history, or prior proposal record; the replacement placeholder is reserved in proposals/metpo_traitmech_v415.
2026-10-02T07:21:43Z · REVIEW_CANONICAL_EXAMPLE_EVIDENCE_GAP · codex
Reviewed Avs V system during initial curation and left canonical_examples empty because Muralidharan et al. and the pinned DefenseFinder tables support Avs5 type V AVAST immunity and the Avs_V model namespace but not an accession-backed native microbial taxon exemplar tied to Avs_V__Avs5A and experimentally verified endogenous Avs V activity. No paid research was used.