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Brc167 system

traitmech:000517 · CLASS · PROPOSED

A phage defense system in which an organism possesses a gcu167/Brc167 bacteriophage-resistance integron cassette that supports growth during bacteriophage challenge.

Trait evidence (7)

  • DOI:10.1126/science.ads0915
    brc167 L 38.3 26.3 16.8 18.5 59.8 0 25.6 21.3

    Manual transcription of the Supplementary Fig. S2 Brc167 low-MOI E. coli IJ1862 heatmap row; the row shows reduced inhibition, including 16.8% for T4, 18.5% for F1, 0% for prophage phi80, 25.6% for HK544, and 21.3% for F13.

  • DOI:10.1126/science.ads0915
    brc167 H 25.0 21.5 11.4 0 83.1 26.1 61.7 27.6

    Manual transcription of the Supplementary Fig. S2 Brc167 high-MOI E. coli IJ1862 heatmap row; the row shows reduced inhibition, including 25.0% for MS2, 21.5% for G4, 11.4% for T4, 0% for F1, and 27.6% for F13.

  • DOI:10.1126/science.ads0915
    brc142 brc167.2 brc167

    Kieffer et al. include brc167 among identified BRiCs with predicted attC secondary structures.

  • DOI:10.1126/science.ads0915
    defense profiles of identified Bacteriophage Resistance integron Cassettes (BRiCs) against a panel of different phages

    Kieffer et al. classify positive integron cassettes as BRiCs and compare their defense profiles across a phage panel.

  • DOI:10.1126/science.ads0915
    C803 pMBA brc167 E. coli IJ1862

    Kieffer et al.'s supplementary construct table lists pMBA brc167 in E. coli IJ1862 for high/low-MOI phage-panel testing.

  • DOI:10.1126/science.ads0915
    C813 pMBA brc167 K. pneumoniae

    Kieffer et al.'s supplementary construct table lists the pMBA brc167 plasmid introduced into Klebsiella pneumoniae KP5.

  • https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md
    | gcu167 | 10\.1126/science\.ads0915 | Mobile integrons encode phage defense systems |

    The pinned DefenseFinder article registry maps the gcu167 source key to the Kieffer et al. mobile-integron BRiC paper.

Brc167 BRiCs confer phage resistance

Conservative system-level sketch linking a gcu167/Brc167 bacteriophage-resistance integron cassette to phage resistance and Brc167 system possession.

NONMECHANISTIC · The graph captures Brc167 at the integron-cassette and phage-resistance-output level without asserting the native host range, exact sensitive-phage breadth outside the reported panels, direct molecular substrate, or a DefenseFinder HMM/rules profile absent from the pinned snapshot.

Brc167 BRiCs confer phage resistance Interactive directed graph showing evidence-backed causal relationships for Brc167 system.

Edge evidence

  • Brc167 integron cassette contributes to Brc167 phage resistance RO:0002326

    The gcu167/Brc167 integron cassette contributes to phage resistance during phage-panel assays.

    • DOI:10.1126/science.ads0915 brc167 L 38.3 26.3 16.8 18.5 59.8 0 25.6 21.3 Manual transcription of the Supplementary Fig. S2 Brc167 low-MOI E. coli IJ1862 heatmap row; the row shows reduced inhibition, including 16.8% for T4, 18.5% for F1, 0% for prophage phi80, 25.6% for HK544, and 21.3% for F13.
    • DOI:10.1126/science.ads0915 brc167 H 25.0 21.5 11.4 0 83.1 26.1 61.7 27.6 Manual transcription of the Supplementary Fig. S2 Brc167 high-MOI E. coli IJ1862 heatmap row; the row shows reduced inhibition, including 25.0% for MS2, 21.5% for G4, 11.4% for T4, 0% for F1, and 27.6% for F13.
  • Brc167 phage resistance confers Brc167 system METPO:2007700

    Brc167-linked phage resistance realizes the Brc167 system possession trait.

    • DOI:10.1126/science.ads0915 brc167 L 38.3 26.3 16.8 18.5 59.8 0 25.6 21.3 Manual transcription of the Supplementary Fig. S2 Brc167 low-MOI E. coli IJ1862 heatmap row; the row shows reduced inhibition, including 16.8% for T4, 18.5% for F1, 0% for prophage phi80, 25.6% for HK544, and 21.3% for F13.
    • DOI:10.1126/science.ads0915 brc167 H 25.0 21.5 11.4 0 83.1 26.1 61.7 27.6 Manual transcription of the Supplementary Fig. S2 Brc167 high-MOI E. coli IJ1862 heatmap row; the row shows reduced inhibition, including 25.0% for MS2, 21.5% for G4, 11.4% for T4, 0% for F1, and 27.6% for F13.
    • DOI:10.1126/science.ads0915 defense profiles of identified Bacteriophage Resistance integron Cassettes (BRiCs) against a panel of different phages Kieffer et al. classify positive integron cassettes as BRiCs and compare their defense profiles across a phage panel.
  • Brc167 system is a phage defense system rdfs:subClassOf

    Brc167 system possession is a phage-defense-system trait.

Provenance

Identifier source
TraitMech local identifier
Definition source
DOI:10.1126/science.ads0915

Parent traits (1)

Synonyms (2)

  • gcu167 RELATED_SYNONYM · https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md
  • brc167 RELATED_SYNONYM · DOI:10.1126/science.ads0915

kg-microbe context

No kg-microbe node embedding matched this record in the 2026-04-25 deepwalk.

Discussions and Knowledge Gaps (1)

Open questions attached to this trait. Seeded by just knowledge-gap-scan and curated; see the corpus-wide index.

Resolve Brc167 native host breadth, exact sensitive-phage breadth, molecular output, and DefenseFinder HMM/rules coverage before minting narrower Brc167 mechanism children.

KNOWLEDGE GAP OPEN brc167-defensefinder-model-gap · raised by codex · 2026-10-01

Attached to causal_graphs#brc167_integron_cassette_confers_phage_resistance

Kieffer et al. identify brc167 as a bacteriophage-resistance integron cassette, and the pinned DefenseFinder article registry maps the gcu167 source key to the same Science article. The pinned HMM inventory and rules table have no exact gcu167 or Brc167 row, so the first-pass record leaves native-host breadth, profile boundaries, exact phage target breadth, and direct molecular output unresolved.

Evidence

Curation history

  1. · MINTED_TRAITMECH_ID · codex

    Minted Brc167 system as a DOI- and DefenseFinder-backed GENOMICS TraitRecord under phage defense system after an ignored-and-hidden duplicate review found no exact live TraitMech, METPO, history, or prior proposal record; kept the graph at BRiC integron-cassette level because the pinned DefenseFinder article registry names gcu167 but the pinned HMM inventory and rules table have no exact Brc167 row; the replacement placeholder is reserved in proposals/metpo_traitmech_v394.

  2. · REVIEW_CANONICAL_EXAMPLE_EVIDENCE_GAP · codex

    Reviewed Brc167 system during initial curation and left canonical_examples empty because the sources support heterologous gcu167/Brc167 phage-resistance assays and a DefenseFinder gcu167 article row, but not a direct named native microbial isolate exemplar with experimentally verified endogenous Brc167 activity. No paid research was used.

  3. · RESOLVED_ADVERSARIAL_REVIEW · codex

    Resolved PR #1521 adversarial review issue #1522 by replacing Brc167 causal-edge support that relied on attC row-label and construct-table fragments with exact low- and high-MOI Brc167 heatmap row transcriptions from Supplementary Fig. S2.