Bunzi system

traitmech:000248 · CLASS · PROPOSED

A phage defense system in which an organism possesses a two-component Bunzi locus represented by BnzA and BnzB profiles that can protect bacteria from bacteriophage infection.

Trait evidence (6)

DOI:10.1016/j.chom.2022.09.017
discovery of 21 defense systems that protect bacteria from phages, based on computational genomic analyses and phage-infection experiments

Millman et al. report the computational and experimental cohort that DefenseFinder cites for Bunzi as a bacterial anti-phage system.
DOI:10.1101/2022.05.11.491447
discovery of 21 new defense systems that protect bacteria from phages, based on computational genomic analyses and phage infection experiments

The bioRxiv version of Millman et al. independently carries the 21-system discovery claim linked from DefenseFinder's Bunzi article registry.
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md
Bunzi | 10\.1101/2022\.05\.11\.491447 | An expanding arsenal of immune systems that protect bacteria from phages

The DefenseFinder model registry maps the named Bunzi system to the Millman et al. antiphage-system discovery preprint.
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/DefenseFinder_rules.tsv
Bunzi__BnzA, Bunzi__BnzB

The DefenseFinder rules table models Bunzi as a two-member system with BnzA and BnzB mandatory profiles.
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md
Bunzi__BnzA | Bunzi__BnzA | Bunzi

The DefenseFinder HMM inventory records BnzA as a Bunzi profile.
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md
Bunzi__BnzB | Bunzi__BnzB | Bunzi

The DefenseFinder HMM inventory records BnzB as a Bunzi profile.

Bunzi loci confer bacterial phage defense

Conservative system-level sketch linking possession of a Bunzi locus to restricted bacteriophage propagation without asserting the unresolved phage trigger or molecular output.

NONMECHANISTIC · The graph captures Bunzi as a named anti-phage system with BnzA and BnzB DefenseFinder profiles while leaving its phage trigger, molecular substrate, antiviral effector output, and subtype breadth unresolved.

Edge evidence

Bunzi locus contributes to restricted phage propagation RO:0002326
DefenseFinder maps Bunzi to a bacterial anti-phage-system discovery preprint and represents Bunzi loci through BnzA and BnzB component profiles.
- DOI:10.1016/j.chom.2022.09.017 discovery of 21 defense systems that protect bacteria from phages Millman et al. describe the anti-phage discovery cohort that the DefenseFinder Bunzi registry row maps to the Bunzi system.
- https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md Bunzi | 10\.1101/2022\.05\.11\.491447 | An expanding arsenal of immune systems that protect bacteria from phages The DefenseFinder registry maps Bunzi itself to the Millman et al. bacterial antiphage-system discovery preprint.
- https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/DefenseFinder_rules.tsv Bunzi__BnzA, Bunzi__BnzB The DefenseFinder rules table supports BnzA and BnzB as the mandatory Bunzi system profiles.
restricted phage propagation confers Bunzi system METPO:2007700
Bunzi-mediated phage restriction realizes the Bunzi system trait.
- DOI:10.1016/j.chom.2022.09.017 discovery of 21 defense systems that protect bacteria from phages Millman et al. place the Bunzi discovery cohort in the set of bacterial systems that protect against phages.
- https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md Bunzi | 10\.1101/2022\.05\.11\.491447 | An expanding arsenal of immune systems that protect bacteria from phages DefenseFinder records Bunzi as a named system from the Millman et al. antiphage discovery preprint.
Bunzi system is a phage defense system rdfs:subClassOf
Bunzi system possession is a phage-defense-system trait.
- https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md An expanding arsenal of immune systems that protect bacteria from phages DefenseFinder associates Bunzi with the Millman et al. bacterial antiphage-system discovery paper.

Provenance

Identifier source: TraitMech local identifier
Definition source: DOI:10.1016/j.chom.2022.09.017

Parent traits (1)

phage defense system traitmech:000209

Synonyms (1)

Bunzi EXACT_SYNONYM · https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md

kg-microbe context

No kg-microbe node embedding matched this record in the 2026-04-25 deepwalk.

Discussions and Knowledge Gaps (1)

Open questions attached to this trait. Seeded by just knowledge-gap-scan and curated; see the corpus-wide index.

Resolve Bunzi phage triggers and effector outputs before minting narrower Bunzi mechanism children.

KNOWLEDGE GAP OPEN bunzi-mechanism-gap · raised by codex · 2026-09-18

Attached to causal_graphs#bunzi_locus_restricts_phage

Millman et al. and DefenseFinder support Bunzi as a named anti-phage system with BnzA and BnzB profiles, but the trigger, molecular substrate, antiviral effector output, and subtype-specific mechanism are not resolved enough here to assert a narrower mechanistic child trait.

Curation history

2026-09-18T19:26:06Z · MINTED_TRAITMECH_ID · codex
Minted Bunzi system as a DOI-backed GENOMICS TraitRecord under phage defense system after an ignored-and-hidden duplicate review found no exact live TraitMech, METPO, or prior proposal record; the replacement placeholder is reserved in proposals/metpo_traitmech_v125.