Dazbog system

traitmech:000245 · CLASS · PROPOSED

A phage defense system in which an organism possesses a two-component Dazbog locus encoding DzbA and DzbB components that can protect bacteria from bacteriophage infection.

Trait evidence (6)

DOI:10.1016/j.chom.2022.09.017
discovery of 21 defense systems that protect bacteria from phages, based on computational genomic analyses and phage-infection experiments

Millman et al. report the computational and experimental cohort in which Dazbog was discovered as a bacterial anti-phage system.
DOI:10.1101/2022.05.11.491447
discovery of 21 new defense systems that protect bacteria from phages, based on computational genomic analyses and phage infection experiments

The bioRxiv version of Millman et al. independently carries the 21-system discovery claim linked from DefenseFinder's Dazbog article registry.
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md
Dazbog | 10\.1101/2022\.05\.11\.491447 | An expanding arsenal of immune systems that protect bacteria from phages

The DefenseFinder model registry maps the named Dazbog system to the Millman et al. antiphage-system discovery preprint.
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/DefenseFinder_rules.tsv
Dazbog__DzbA, Dazbog__DzbB

The DefenseFinder rules table models Dazbog as a two-member system with DzbA and DzbB mandatory profiles.
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md
Dazbog__DzbA

The DefenseFinder HMM inventory records DzbA as a Dazbog profile.
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md
Dazbog__DzbB

The DefenseFinder HMM inventory records DzbB as a Dazbog profile.

Dazbog loci confer bacterial phage defense

Conservative system-level sketch linking possession of a Dazbog locus to restricted bacteriophage propagation without asserting the unresolved phage trigger or molecular output.

NONMECHANISTIC · The graph captures the Dazbog system as a DzbA/DzbB anti-phage locus while leaving its phage trigger, enzymatic substrate, effector output, cell-death or survival outcome, and subtype breadth unresolved.

Edge evidence

Dazbog locus contributes to restricted phage propagation RO:0002326
The Dazbog locus encodes the DzbA and DzbB components of a two-component Dazbog anti-phage system.
- https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/DefenseFinder_rules.tsv Dazbog__DzbA, Dazbog__DzbB The DefenseFinder rules table supports DzbA and DzbB as the mandatory Dazbog system profiles.
restricted phage propagation confers Dazbog system METPO:2007700
Dazbog-mediated phage restriction realizes the Dazbog system trait.
- DOI:10.1016/j.chom.2022.09.017 discovery of 21 defense systems that protect bacteria from phages Millman et al. place the Dazbog discovery cohort in the set of bacterial systems that protect against phages.
- https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md 10\.1101/2022\.05\.11\.491447 | An expanding arsenal of immune systems DefenseFinder records Dazbog as a named system from the Millman et al. antiphage discovery preprint.
Dazbog system is a phage defense system rdfs:subClassOf
Dazbog system possession is a phage-defense-system trait.
- https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md An expanding arsenal of immune systems that protect bacteria from phages DefenseFinder associates Dazbog with the Millman et al. bacterial antiphage-system discovery paper.

Provenance

Identifier source: TraitMech local identifier
Definition source: DOI:10.1016/j.chom.2022.09.017

Parent traits (1)

phage defense system traitmech:000209

Synonyms (1)

Dazbog EXACT_SYNONYM · https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md

kg-microbe context

No kg-microbe node embedding matched this record in the 2026-04-25 deepwalk.

Discussions and Knowledge Gaps (1)

Open questions attached to this trait. Seeded by just knowledge-gap-scan and curated; see the corpus-wide index.

Resolve Dazbog phage triggers and effector outputs before minting narrower Dazbog mechanism children.

KNOWLEDGE GAP OPEN dazbog-mechanism-gap · raised by codex · 2026-09-18

Not yet attached to a section of this record — a curator sets attaches_to (e.g. causal_graphs#some_edge) so the gap shows beside the mechanism it concerns.

Millman et al. and DefenseFinder support Dazbog as a named DzbA/DzbB anti-phage locus, but the trigger, molecular substrate, antiviral effector output, and death-or-survival phenotype are not resolved enough here to assert a narrower mechanistic child trait.

Curation history

2026-09-18T16:14:42Z · MINTED_TRAITMECH_ID · codex
Minted Dazbog system as a DOI-backed GENOMICS TraitRecord under phage defense system after an ignored-and-hidden duplicate review found no exact live TraitMech, METPO, or prior proposal record; the replacement placeholder is reserved in proposals/metpo_traitmech_v122.