Detocs system

traitmech:000302 · CLASS · PROPOSED

A phage defense system in which an organism possesses a Detocs locus represented in DefenseFinder by DtcA and DtcB profiles plus optional DtcC-family profiles, with an ATP nucleosidase output that can degrade ATP and dATP upon phage infection and halt phage propagation.

Trait evidence (8)

DOI:10.1016/j.cell.2023.07.020
By analyzing homologs of the immune ATP nucleosidase domain, we discover and characterize Detocs, a family of bacterial defense systems with a two-component phosphotransfer-signaling architecture

Rousset et al. discover Detocs from immune ATP nucleosidase domain homologs and name it as a bacterial defense-system family with two-component phosphotransfer-signaling architecture.
DOI:10.1016/j.cell.2023.07.020
upon phage infection, degrade cellular adenosine triphosphate (ATP) and deoxyadenosine triphosphate (dATP)

Rousset et al. support ATP and dATP degradation as a phage-triggered bacterial immune output.
DOI:10.1016/j.cell.2023.07.020
ATP and dATP degradation during infection halts phage propagation

Rousset et al. connect ATP and dATP degradation to inhibition of phage propagation.
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md
Detocs | 10\.1101/2023\.01\.24\.525353 | A conserved family of immune effectors cleaves cellular ATP upon viral infection

The DefenseFinder article registry maps the named Detocs system to the Rousset et al. ATP-cleavage preprint.
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/DefenseFinder_rules.tsv
Detocs Detocs 2 2 Detocs__dtcA, Detocs__dtcB Detocs__dtcC

The DefenseFinder rules table models the core Detocs system with required dtcA and dtcB profiles and an optional dtcC profile.
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md
| Detocs__dtcA | Detocs__dtcA | Detocs | Custom | 30 |

The DefenseFinder HMM inventory records dtcA under the Detocs model namespace.
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md
| Detocs__dtcB | Detocs__dtcB | Detocs | Custom | 40 |

The DefenseFinder HMM inventory records dtcB under the Detocs model namespace.
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md
| Detocs__dtcC | Detocs__dtcC | Detocs | Custom | 40 |

The DefenseFinder HMM inventory records dtcC under the Detocs model namespace.

Detocs loci connect phage infection to ATP depletion

Conservative system-level sketch linking possession of a Detocs locus to phage-associated ATP and dATP degradation, halted phage propagation, and the Detocs system trait without asserting the direct phage trigger or component-specific activation mechanism.

NONMECHANISTIC · The graph captures Detocs as a named ATP-depletion anti-phage system with DtcA, DtcB, and DtcC-family DefenseFinder profiles while leaving the direct phage trigger, component-specific phosphotransfer sequence, DtcC-variant effects, and universal system boundary unresolved.

Edge evidence

Detocs locus contributes to phage-associated ATP and dATP degradation RO:0002326
Rousset et al. connect ATP nucleosidase-domain bacterial immune effectors to phage-associated ATP and dATP degradation and discovered Detocs from ATP nucleosidase domain homologs; DefenseFinder catalogs Detocs with dtcA, dtcB, and dtcC-family profiles.
- DOI:10.1016/j.cell.2023.07.020 By analyzing homologs of the immune ATP nucleosidase domain, we discover and characterize Detocs, a family of bacterial defense systems Rousset et al. identify Detocs from homologs of immune ATP nucleosidase domains.
- DOI:10.1016/j.cell.2023.07.020 upon phage infection, degrade cellular adenosine triphosphate (ATP) and deoxyadenosine triphosphate (dATP) Rousset et al. support ATP and dATP degradation as a phage-triggered bacterial immune output.
- https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/DefenseFinder_rules.tsv Detocs Detocs 2 2 Detocs__dtcA, Detocs__dtcB Detocs__dtcC The DefenseFinder rules table models the core Detocs system with required dtcA and dtcB profiles and an optional dtcC profile.
- https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md | Detocs__dtcA | Detocs__dtcA | Detocs | Custom | 30 | The DefenseFinder HMM inventory records dtcA under the Detocs model namespace.
- https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md | Detocs__dtcB | Detocs__dtcB | Detocs | Custom | 40 | The DefenseFinder HMM inventory records dtcB under the Detocs model namespace.
- https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md | Detocs__dtcC | Detocs__dtcC | Detocs | Custom | 40 | The DefenseFinder HMM inventory records dtcC under the Detocs model namespace.
phage-associated ATP and dATP degradation contributes to halted phage propagation RO:0002326
ATP and dATP degradation during infection contributes to halted phage propagation.
- DOI:10.1016/j.cell.2023.07.020 ATP and dATP degradation during infection halts phage propagation Rousset et al. connect ATP and dATP degradation to halted phage propagation.
halted phage propagation confers Detocs system METPO:2007700
Detocs-associated ATP and dATP depletion realizes the Detocs system trait.
- DOI:10.1016/j.cell.2023.07.020 ATP and dATP degradation during infection halts phage propagation Rousset et al. connect ATP and dATP degradation to inhibition of phage propagation.
- DOI:10.1016/j.cell.2023.07.020 we discover and characterize Detocs, a family of bacterial defense systems Rousset et al. support Detocs as a named bacterial defense-system family.
- https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md Detocs | 10\.1101/2023\.01\.24\.525353 | A conserved family of immune effectors cleaves cellular ATP upon viral infection The DefenseFinder article registry maps the named Detocs system to the Rousset et al. ATP-cleavage preprint.
Detocs system is a phage defense system rdfs:subClassOf
Detocs system possession is a phage-defense-system trait.
- DOI:10.1016/j.cell.2023.07.020 we discover and characterize Detocs, a family of bacterial defense systems Rousset et al. place Detocs in a bacterial defense-system family.
- https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md Detocs | 10\.1101/2023\.01\.24\.525353 | A conserved family of immune effectors cleaves cellular ATP upon viral infection The DefenseFinder article registry maps the named Detocs system to the Rousset et al. ATP-cleavage preprint.

Provenance

Identifier source: TraitMech local identifier
Definition source: DOI:10.1016/j.cell.2023.07.020

Parent traits (1)

phage defense system traitmech:000209

Synonyms (1)

Detocs EXACT_SYNONYM · https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md

kg-microbe context

No kg-microbe node embedding matched this record in the 2026-04-25 deepwalk.

Discussions and Knowledge Gaps (1)

Open questions attached to this trait. Seeded by just knowledge-gap-scan and curated; see the corpus-wide index.

Resolve Detocs phage triggers, component-specific phosphotransfer events, and DtcC-family effector outputs before minting narrower Detocs mechanism children.

KNOWLEDGE GAP OPEN detocs-component-mechanism-gap · raised by codex · 2026-09-20

Attached to causal_graphs#detocs_locus_depletes_atp

Rousset et al. support Detocs as a named family of two-component phosphotransfer-signaling bacterial defense systems, and DefenseFinder represents Detocs with required dtcA and dtcB profiles plus optional dtcC-family profiles. This system-level record leaves the direct phage trigger, component-specific activation route, exact ATP nucleosidase effector architecture, and DtcC-variant outputs unresolved.

Curation history

2026-09-20T06:11:22Z · MINTED_TRAITMECH_ID · codex
Minted Detocs system as a DOI-backed GENOMICS TraitRecord under phage defense system after an ignored-and-hidden duplicate review found no exact live TraitMech, METPO, or prior proposal record; the replacement placeholder is reserved in proposals/metpo_traitmech_v179.
2026-09-20T06:54:24Z · ADDRESS_PR_REVIEW · codex
Quoted the Cell abstract sentence that names Detocs as a bacterial defense-system family and moved the Detocs phage-defense subclass edge off a weaker ATP-degradation fragment after the PR 1117 adversarial review filed issue 1119.
2026-09-20T07:11:29Z · ADDRESS_PR_REVIEW · codex
Attached direct ATP and dATP degradation evidence to the Detocs locus causal edge and halted-propagation evidence to the Detocs trait-conferral edge after the PR 1117 adversarial review filed issue 1121.